Metabolic imbalance driving immune cell phenotype switching in autoimmune disorders: Tipping the balance of T‐ and B‐cell interactions

Clinical and Translational Medicine, Journal Year: 2024, Volume and Issue: 14(3)

Published: March 1, 2024

The interplay between the immune system and metabolic state of a cell is intricate. In all phases an response, corresponding changes shall occur to support its modulation, in addition signalling through cytokine environment receptor stimulation. While autoimmune disorders may develop because imbalance that modulates switching T-cell phenotypes, effects interaction T B cells have on one another's cellular metabolism are yet be understood disease context. Here, we propose perspective which highlights potential targeting modulate T- B-cell subtypes populations as well T-B B-T interactions successfully treat disorders. Specifically, envision how can tip balance interactions, definite mechanisms both health disease, explain phenotype switches cells. Within this scenario, highlight link inflammation, immunometabolism, epigenetics ageing, critical understand inflammatory combination treatments cause (T/B) imbalances, pathways involved, increase effectiveness treatment disorders, and/or ameliorate their symptoms improve patients' quality life.

Language: Английский

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Impact of immune cell metabolism on membranous nephropathy and prospective therapy

Communications Biology, Journal Year: 2025, Volume and Issue: 8(1)

Published: March 10, 2025

Membranous nephropathy (MN) is a primary glomerular disease commonly causing adult nephrotic syndrome. Characterized by thickened capillary walls due to immune complex deposition, MN autoimmune disorder. Its pathogenesis involves deposit formation, complement activation, and heightened risk of renal failure. Central system dysfunction, particularly the dysregulation B T cell responses. cells contribute injury through production autoantibodies, IgG targeting phospholipase A2 receptor (PLA2R) on podocytes, while modulate responses that influence progression. Metabolic reprogramming alters lymphocyte survival, differentiation, proliferation, function, potentially triggering processes. Although link between metabolism remains underexplored, this review highlights recent advances in understanding its role MN. These insights may provide novel biomarkers therapeutic strategies for treatment. Immune membranous drives Dysregulated B/T metabolic trigger autoimmunity, offering potential therapies

Language: Английский

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Immunosenescence in autoimmune diseases

Autoimmunity Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 103805 - 103805

Published: March 1, 2025

Language: Английский

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A new perspective on therapies involving B-cell depletion in autoimmune diseases

Molecular Biology Reports, Journal Year: 2024, Volume and Issue: 51(1)

Published: May 8, 2024

Language: Английский

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Metabolic modeling to study bacterial composition for probiotic and prebiotic production

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: unknown, P. 157852 - 157852

Published: Nov. 1, 2024

Language: Английский

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TCR-CD3 signal strength regulates plastic coexpression of IL-4 and IFN-γ in Tfh-like cells

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 8, 2024

The development of T follicular helper (Tfh) cells is an ongoing process resulting in the formation various Tfh subsets. Despite advancements, precise impact cell receptor (TCR) stimulation on this remains incompletely understood. This study explores how TCR-CD3 signaling strength influences naive CD4

Language: Английский

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Causal association between non-thyroidal autoimmune diseases and Graves' ophthalmopathy: a mendelian randomization study

Advances in Ophthalmology Practice and Research, Journal Year: 2024, Volume and Issue: 5(1), P. 66 - 72

Published: Nov. 22, 2024

Language: Английский

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