Frontiers in Oncology,
Journal Year:
2024,
Volume and Issue:
14
Published: March 26, 2024
The
discovery
and
use
of
exosomes
ushered
in
a
new
era
cell-free
therapy.
Exosomes
are
subgroup
extracellular
vesicles
that
show
great
potential
disease
treatment.
Engineered
exosomes.
with
their
improved
functions
have
attracted
intense
interests
application
translational
medicine
research.
However,
the
technology
engineering
still
faces
many
challenges
which
been
limitation
for
clinical
application.
This
review
summarizes
current
status
research
on
engineered
difficulties
encountered
recent
years,
view
to
providing
approaches
ideas
future
exosome
modification
drug
development.
Frontiers in Endocrinology,
Journal Year:
2022,
Volume and Issue:
13
Published: Sept. 15, 2022
In
recent
years,
the
risk,
such
as
hypertension,
obesity
and
diabetes
mellitus,
of
cardiovascular
diseases
has
been
increasing
explosively
with
development
living
conditions
expansion
social
psychological
pressure.
The
disturbance
glucose
lipid
metabolism
contributes
to
both
collapse
myocardial
structure
cardiac
dysfunction,
which
ultimately
leads
diabetic
cardiomyopathy.
pathogenesis
cardiomyopathy
is
multifactorial,
including
inflammatory
cascade
activation,
oxidative/nitrative
stress,
following
impaired
Ca2+
handling
induced
by
insulin
resistance/hyperinsulinemia,
hyperglycemia,
hyperlipidemia
in
diabetes.
Some
key
alterations
cellular
signaling
network,
translocation
CD36
sarcolemma,
activation
NLRP3
inflammasome,
up-regulation
AGE/RAGE
system,
disequilibrium
micro-RNA,
mediate
oxidative
stress/inflammation
related
remodeling
ventricular
dysfunction
context
metabolic
disturbance.
Here,
we
summarized
detailed
network
abnormality
facilitates
International Journal of Molecular Medicine,
Journal Year:
2023,
Volume and Issue:
51(6)
Published: April 24, 2023
Diabetic
cardiomyopathy
(DCM)
is
a
cardiovascular
disease
which
has
been
reported
as
major
cause
of
mortality
worldwide
for
several
years.
Berberine
(BBR)
natural
compound
extracted
from
Chinese
herb,
with
clinically
anti‑DCM
effect;
however,
its
molecular
mechanisms
have
not
yet
fully
elucidated.
The
present
study
indicated
that
BBR
markedly
alleviated
DCM
by
inhibiting
IL‑1β
secretion
and
the
expression
gasdermin
D
(Gsdmd)
at
post‑transcriptional
level.
Considering
importance
microRNAs
(miRNAs/miRs)
in
regulation
process
specific
genes,
ability
to
upregulate
levels
miR‑18a‑3p
activating
promoter
(‑1,000/‑500)
was
examined.
Notably,
targeted
Gsdmd
abated
pyroptosis
high
glucose‑treated
H9C2
cells.
Moreover,
overexpression
inhibited
improved
biomarkers
cardiac
function
rat
model
DCM.
On
whole,
findings
indicate
alleviates
miR‑18a‑3p‑mediated
activation;
thus,
may
be
considered
potential
therapeutic
agent
treatment
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(7), P. 6214 - 6214
Published: March 25, 2023
Diabetic
nephropathy
is
one
of
the
most
common
and
severe
complications
diabetes
mellitus,
affecting
in
every
five
patients
suffering
from
diabetes.
Despite
extensive
research,
exact
pathogenesis
diabetic
still
unclear.
Several
factors
pathways
are
known
to
be
involved
development
disease,
such
as
reactive
oxygen
species
or
activation
renin–angiotensin–aldosterone
system.
The
expression
those
proteins
might
extensively
regulated
by
microRNA.
Recent
research
suggests
that
patients,
profile
miRNA
significantly
changed.
In
this
review,
we
focus
on
actions
various
clinical
usage
miRNAs
biomarkers
therapeutic
targets.
Frontiers in Public Health,
Journal Year:
2023,
Volume and Issue:
11
Published: April 13, 2023
The
objective
of
this
study
is
to
conduct
a
comprehensive
bibliometric
analysis
identify
and
evaluate
global
trends
in
diabetic
retinopathy
(DR)
research
visualize
the
focus
frontiers
field.Diabetic
retinopathy-related
publications
from
establishment
Web
Science
(WOS)
through
1
November
2022
were
retrieved
for
qualitative
quantitative
analyses.
This
analyzed
annual
publication
counts,
prolific
countries,
institutions,
journals,
top
10
most
cited
literature.
findings
presented
descriptive
statistics.
VOSviewer
1.6.17
was
used
exhibit
keywords
with
high
frequency
national
cooperation
networks,
while
CiteSpace
5.5.R2
displayed
timeline
burst
each
term.A
total
10,709
references
analyzed,
number
continuously
increased
over
investigated
period.
America
had
highest
h-index
citation
frequency,
contributing
influence.
China
country,
producing
3,168
articles.
University
London
productivity.
three
productive
journals
America,
Investigative
Ophthalmology
Visual
publications.
article
Gulshan
et
al.
(2016;
co-citation
2,897)
served
as
representative
symbolic
reference.
main
topics
area
incidence,
pathogenesis,
treatment,
artificial
intelligence
(AI).
Deep
learning,
models,
biomarkers,
optical
coherence
tomography
angiography
(OCTA)
DR
frontier
hotspots.Bibliometric
provided
valuable
insights
into
frontiers.
Four
key
directions
extracted
extensive
DR-related
As
incidence
continues
increase,
prevention
treatment
have
become
pressing
public
health
concern
significant
interest.
In
addition,
development
AI
technologies
telemedicine
has
emerged
promising
balancing
doctors
patients.
Frontiers in Oncology,
Journal Year:
2024,
Volume and Issue:
14
Published: March 26, 2024
The
discovery
and
use
of
exosomes
ushered
in
a
new
era
cell-free
therapy.
Exosomes
are
subgroup
extracellular
vesicles
that
show
great
potential
disease
treatment.
Engineered
exosomes.
with
their
improved
functions
have
attracted
intense
interests
application
translational
medicine
research.
However,
the
technology
engineering
still
faces
many
challenges
which
been
limitation
for
clinical
application.
This
review
summarizes
current
status
research
on
engineered
difficulties
encountered
recent
years,
view
to
providing
approaches
ideas
future
exosome
modification
drug
development.
