Inflammaging as a common ground for the development and maintenance of sarcopenia, obesity, cardiomyopathy and dysbiosis

Ageing Research Reviews, Journal Year: 2019, Volume and Issue: 56, P. 100980 - 100980

Published: Nov. 11, 2019

Language: Английский

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The Diabetic Cardiomyopathy: The Contributing Pathophysiological Mechanisms

Frontiers in Medicine, Journal Year: 2021, Volume and Issue: 8

Published: June 30, 2021

Individuals with diabetes mellitus (DM) disclose a higher incidence and poorer prognosis of heart failure (HF) than non-diabetic people, even in the absence other HF risk factors. The adverse impact on likely reflects an underlying "diabetic cardiomyopathy" (DM-CMP), which may by exacerbated left ventricular hypertrophy coronary artery disease (CAD). pathogenesis DM-CMP has been hot topic research since its first description is still under active investigation, as complex interplay among multiple mechanisms play role at systemic, myocardial, cellular/molecular levels. Among these, metabolic abnormalities such lipotoxicity glucotoxicity, mitochondrial damage dysfunction, oxidative stress, abnormal calcium signaling, inflammation, epigenetic factors, others. These disturbances predispose diabetic to extracellular remodeling hypertrophy, thus leading diastolic systolic dysfunction. This Review aims outline major pathophysiological changes myocardial cardiac functional derangement DM-CMP.

Language: Английский

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Effect of SGLT2 Inhibitors on the Sympathetic Nervous System and Blood Pressure

Current Cardiology Reports, Journal Year: 2019, Volume and Issue: 21(8)

Published: June 21, 2019

Language: Английский

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The Hemoglobin, Albumin, Lymphocyte, and Platelet (HALP) Score in Patients with Small Cell Lung Cancer Before First-Line Treatment with Etoposide and Progression-Free Survival

Medical Science Monitor, Journal Year: 2019, Volume and Issue: 25, P. 5630 - 5639

Published: July 29, 2019

BACKGROUND:The hemoglobin, albumin, lymphocyte, and platelet (HALP) score is a prognostic factor in patients who have some types of malignant tumors. The aim this study was to investigate the significance HALP with small cell lung cancer (SCLC) before first-line treatment etoposide. MATERIAL AND METHODS:A retrospective included 178 SCLC received chemotherapy etoposide between September 2015 May 2019. baseline clinical characteristics blood parameters were recorded. Univariate multivariate analysis Kaplan-Meier plots used identify factors associated progression-free survival (PFS). RESULTS:The optimal cut-off values determined by X-tile software be 25.8. showed that patients, score, body mass index (BMI), serum albumin levels had no significance. In patient age group <65 years, BMI ≥24 kg/m² an independent (HR, 1.943; 95% CI, 1.251–3.018) (P=0.003). ≥65 >25.8 positive for outcome following 0.483; 0.270–0.865) (P=0.014). CONCLUSIONS:In years underwent etoposide, factor, predictor improved outcome, increased PFS.

Language: Английский

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Waist-to-height ratio and body fat percentage as risk factors for ischemic cardiovascular disease: a prospective cohort study from UK Biobank

American Journal of Clinical Nutrition, Journal Year: 2024, Volume and Issue: 119(6), P. 1386 - 1396

Published: May 9, 2024

The independent effect of waist-to-height ratio (WHtR) and body fat percentage (BF%) on ischemic cardiovascular disease (CVD) remains uncertain.

Language: Английский

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Lycopene corrects metabolic syndrome and liver injury induced by high fat diet in obese rats through antioxidant, anti-inflammatory, antifibrotic pathways

Biomedicine & Pharmacotherapy, Journal Year: 2021, Volume and Issue: 141, P. 111831 - 111831

Published: July 6, 2021

Obesity is a global epidemic disease that closely associated with various health problems as Diabetes mellitus, cardiovascular, and metabolic disorders. Lycopene (LYC), red-colored carotenoid, has demonstrated promising therapeutic effects. Hence, the potential of LYC was studied against high fat diet (HFD)-induced obesity disturbances in rats. Animals fed on HFD orally supplemented (25 50 mg/kg) or simvastatin (10 every day for 3 months. The results revealed long-term consumption significantly increased weight gain, liver weight, cholesterol, triglycerides (TG), apolipoprotein-B (Apo-B), low-density lipoprotein-cholesterol (LDL-c) levels, well decreasing high-density (HDL-c) levels. Moreover, blood glucose insulin levels accompanied by low peroxisome proliferator activated receptor gamma (PPAR-γ) were recorded group. Further, rats displayed lower antioxidant biomarkers (SOD, CAT, GPx, GR GSH), addition to higher MDA, NO inflammatory mediators (IL-1β, TNF-α, MPO). Marked increases observed atherogenic index, lactate dehydrogenase creatine kinase together fibrosis markers (TGF-β1 α-SMA) HFD. Comparing model group, able effectively reverse HFD-mediated alterations at dose dependent manner. Altogether, dietary supplementation successfully reversed HFD-induced through its antioxidant, anti-inflammatory, anti-fibrotic properties. manage pathologies.

Language: Английский

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Natural products targeting inflammation-related metabolic disorders: A comprehensive review

Heliyon, Journal Year: 2023, Volume and Issue: 9(6), P. e16919 - e16919

Published: June 1, 2023

Currently, the incidence of metabolic disorders is increasing, setting a challenge to global health. With major advancement in diagnostic tools and clinical procedures, much has been known etiology their corresponding pathophysiologies. In addition, use vitro vivo experimental models prior studies promoted numerous biomedical breakthroughs, including discovery development drug candidates treat disorders. Indeed, chemicals isolated from natural products have extensively studied as prospective manage diabetes, obesity, heart-related diseases, cancer, partly due antioxidant anti-inflammatory properties. Continuous efforts made parallel improve bioactivity bioavailability using selected delivery approaches. Here, we provide insights on recent progress role inflammatory-mediated responses initiation disorders, with particular reference diabetes mellitus, cancer. discussed management cancers lists potential biological targets for high throughput screening development. Lastly, findings observed preclinical identifying suitable approaches phytochemical systems that are be used treatment

Language: Английский

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Undertreatment of cardiovascular risk factors in the type 1 diabetes exchange clinic network (United States) and the prospective diabetes follow‐up (Germany/Austria) registries

Diabetes Obesity and Metabolism, Journal Year: 2020, Volume and Issue: 22(9), P. 1577 - 1585

Published: April 24, 2020

To examine the control of cardiovascular risk factors in type 1 diabetes (T1D) registries from United States and Germany/Austria.Data on individuals aged ≥12 years with T1D for ≥1 year, Exchange Clinic Network (T1DX, States) Prospective Diabetes Follow-up Registry (DPV, Germany/Austria) January 2016 to 31 March 2018 were analysed. Linear logistic regression models adjusted age groups, sex, duration minority status used compare clinical characteristics achievement management targets between registries.The cohort consisted 47 936 patients n = 19 442; DPV, 28 494). Achievement HbA1c goals (<7.0%, ages 18-65 years; all others, <7.5%) was better DPV those <65 (all P < .001). However, more older adults (aged ≥65 years) T1DX achieved an goal <7.5% compared (70% vs. 50%, The frequency overweight (53% 51%, .001) obesity (19% 9%, higher T1DX. meeting blood pressure (84% 66%, lipid (73% 62%, T1DX; this observed across groups Few young <26 received antihypertensive lipid-lowering medications, respectively, despite indications both (T1DX: 5% 3%, DPV: 3% 1%).A achieve glycaemic majority are inadequately treated hypertension dyslipidaemia. This highlights need improved strategies T1D.

Language: Английский

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Navigating obesity: A comprehensive review of epidemiology, pathophysiology, complications and management strategies

The Innovation Medicine, Journal Year: 2024, Volume and Issue: 2(3), P. 100090 - 100090

Published: Jan. 1, 2024

<p>Obesity, a growing global health crisis, is driven by complex interplay of genetic, biological, environmental, behavioral, socio-cultural, and economic factors. This comprehensive review encapsulates the epidemiology, pathophysiological mechanism, myriad complications it triggers, such as cardiovascular diseases (CVDs), cancer, neurological disorders, respiratory ailments, digestive diseases, mobility impairments, psychological stress. The etiology obesity multifaceted, involving genetic predispositions, environmental influences, behavioral tendencies, socio-economic elements. underpinnings encompass multifaceted aspects energy metabolism, including regulation appetite, glucose, lipid, amino acid metabolism. also addresses seemingly contradictory roles in various offering insights into these phenomena. management multi-pronged, lifestyle modifications, pharmacological interventions, metabolic surgeries. Lifestyle changes are foundational, but advancements molecular techniques, digital technology, wearable devices, artificial intelligence opening new avenues for personalized treatment early intervention. Pharmacological surgery effective should be judiciously tailored to individual patient needs. underscores importance approach management, aiming curb escalating trend enhance future interventions treatments. ultimate goal synthesize current evidence innovative strategies combat effectively.</p>

Language: Английский

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Burnout and Metabolic Syndrome in Female Nurses: An Observational Study

International Journal of Environmental Research and Public Health, Journal Year: 2019, Volume and Issue: 16(11), P. 1993 - 1993

Published: June 5, 2019

Nurses are at risk of having burnout due to workload and job stress-studies have reported that chronic stress is associated with metabolic syndrome. This study aimed assess the association between syndrome in a sample female nurses. Data were collected from cross-sectional 2016 2018 tertiary hospital Mexico City. All nurses work invited participate. Information pertaining sociodemographic (age, education level), (labor seniority, service area, shift work), anthropometric (weight, waist circumference, blood pressure) biochemical (glucose, serum lipids) variables collected. Burnout was assessed using Maslach Inventory test, defined according International Diabetes Federation criteria. A total 168 participated median age 44 years. The prevalence 19.6% 38.7%, respectively. There no (p = 0.373). However, associations emotional exhaustion (aOR: 14.95; 95% CI: 1.5-148.7), personal accomplishment 0.13; 0.01-0.99), night 12.39; 1.02-150.5) increased circumference found. Strategies needed prevent nurses, especially those who shift.

Language: Английский

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