Peptidergic modulation of a multi-functional central pattern generator in the pulmonate snail DOI Open Access
Siddharth Ramakrishnan,

A. D. Murphy

Journal of Experimental Biology, Journal Year: 2022, Volume and Issue: 225(24)

Published: Dec. 7, 2022

Egg laying in pulmonate snails is a well-orchestrated process that involves period of reduced locomotion, followed by substrate cleaning with rhythmic rasping the surface to make tiny grooves, into which eggs are deposited. Although neurohormonal control initiating egg has been well established, signals modulate buccal central pattern generator during not known. Neuropeptides invertebrate gonadotropin-releasing hormone/corazonin family (invGnRH/CRZ) have shown be involved reproduction and allied behaviors many vertebrates invertebrates. Here, we show motor underlying altered vertebrate GnRH agonist. Signals from intestinal nerve innervating reproductive structures, previously both necessary sufficient for egg-laying behaviors, blocked antagonist. Further, GnRH-triggered response elicits rhythmic, phase 2 non-phase activity pattern, shutdown 3, indicative repetitive without accompanied swallowing behavior. Using immunohistochemistry, intracellular electrophysiology extracellular stimulation, member invGnRH/CRZ neuropeptides could signal contextually switches multifunctional CPG biphasic rhythm underlies behavior snail Planorbella (Helisoma) trivolvis.

Language: Английский

Functional evolution of vertebrate sensory receptors DOI
Maude W. Baldwin, Meng‐Ching Ko

Hormones and Behavior, Journal Year: 2020, Volume and Issue: 124, P. 104771 - 104771

Published: June 7, 2020

Language: Английский

Citations

35
The sensory-effector cycle, contributions from a native species DOI
Michel Borde, Ángel A. Caputi

Neuroscience, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

0
Social behavior in South American electric fishes: Linking neuroendocrine Regulation, signal Plasticity, and reproductive strategies DOI
Laura Quintana,

Vielka L. Salazar

Neuroscience, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
A Teleost Fish Model to Understand Hormonal Mechanisms of Non-breeding Territorial Behavior DOI Creative Commons
Ana Silva,

Lucía Zubizarreta,

Laura Quintana

et al.

Frontiers in Endocrinology, Journal Year: 2020, Volume and Issue: 11

Published: July 23, 2020

Aggressive behaviors occurring dissociated from the breeding season encourage search of non-gonadal underlying regulatory mechanisms. Brain estrogen has been shown to be a key modulator this behavior in bird and mammal species, it remains understood if is common mechanism across vertebrates. This review focuses on contributions Gymnotus omarorum, first teleost species which estrogenic modulation non-breeding aggression demonstrated. omarorum displays year-long aggression, well characterized season. In natural habitat, territory size independent sex determined by body size. During season, other hand, no longer correlates size, but rather circulating estrogens gonadosomatic index females, 11-ketotestosterone males. The hormonal mechanisms have explored dyadic encounters lab settings. Males females display robust aggressive contests, whose outcome depends only asymmetry. agonistic gonadal hormones fast acting androgens. Nevertheless, dependent action, as acute aromatase blockers affect engagement, intensity, outcome. Transcriptomic profiling preoptic area region shows individuals express steroidogenic enzyme transcripts. model reveals there role brain control seems among distant vertebrate species.

Language: Английский

Citations

24
Brain and circulating steroids in an electric fish: Relevance for non-breeding aggression DOI Creative Commons

Lucía Zubizarreta,

Cecilia Jalabert, Ana Silva

et al.

PLoS ONE, Journal Year: 2023, Volume and Issue: 18(10), P. e0289461 - e0289461

Published: Oct. 10, 2023

Steroids play a crucial role in modulating brain and behavior. While traditionally it is thought that the target of sex steroids produced endocrine glands (e.g. gonads), itself produces steroids, known as neurosteroids. Neurosteroids can be regions involved regulation social behaviors may act locally to regulate behaviors, such reproduction aggression. Our model species, weakly electric fish Gymnotus omarorum , displays non-breeding aggression both sexes. This valuable natural behavior understand neuroendocrine mechanisms differ from those underlying breeding In season, circulating steroid levels are low, which facilitates study Here, for first time teleost fish, we used liquid chromatography-tandem mass spectrometry (LC-MS/MS) quantify panel 8 plasma characterize profiles wild adult males females. We show that: 1) systemic season similar sexes, although only have detectable 11-ketotestosterone, 2) sexually dimorphic, females display higher androstenedione, testosterone estrone, had 3) androgens androstenedione potential precursors neuroestrogen synthesis, 4) estrogens, key aggression, (but not plasma) These data consistent with previous studies G . dependent on estrogen signaling, has also been shown bird mammal models. Overall, our results provide foundation understanding neurosteroids, interplay between central peripheral differences behaviors.

Language: Английский

Citations

6
Vocal and Electric Fish: Revisiting a Comparison of Two Teleost Models in the Neuroethology of Social Behavior DOI Creative Commons
Kent D. Dunlap,

Haley M. Koukos,

Boris P. Chagnaud

et al.

Frontiers in Neural Circuits, Journal Year: 2021, Volume and Issue: 15

Published: Aug. 19, 2021

The communication behaviors of vocal fish and electric are among the vertebrate social best understood at level neural circuits. Both forms signaling rely on midbrain inputs to hindbrain pattern generators that activate peripheral effectors (sonic muscles electrocytes) produce pulsatile signals modulated by frequency/repetition rate, amplitude call duration. To generate vary sex, male phenotype, context, these circuits responsive a wide range hormones neuromodulators acting different timescales multiple loci. Bass Zakon (2005) reviewed behavioral neuroendocrinology two teleost groups, comparing how regulation their systems have both converged diverged during parallel evolution. Here, we revisit this comparison review complementary developments over past 16 years. We (a) summarize recent work expands our knowledge underlying systems, (b) studies action (e.g., serotonin, AVT, melatonin), brain steroidogenesis ( via aromatase), stimuli output circuits, (c) highlight transcriptomic illustrate contemporary molecular methods elucidated genetic behavior in fish, (d) describe mochokid catfish, which use communication, consider spliced together same species. Finally, offer avenues for future research further probe similarities differences between emerge ontogeny

Language: Английский

Citations

11
Understanding daily rhythms in weakly electric fish: the role of melatonin on the electric behavior of Brachyhypopomus gauderio DOI
Juan I. Vazquez, Valentina Gascue, Laura Quintana

et al.

Journal of Comparative Physiology A, Journal Year: 2023, Volume and Issue: 210(1), P. 7 - 18

Published: April 1, 2023

Language: Английский

Citations

4
Roles for cerebellum and subsumption architecture in central pattern generation DOI Creative Commons
John C. Montgomery

Journal of Comparative Physiology A, Journal Year: 2023, Volume and Issue: 210(2), P. 315 - 324

Published: May 2, 2023

Abstract Within vertebrates, central pattern generators drive rhythmical behaviours, such as locomotion and ventilation. Their generation is also influenced by sensory input various forms of neuromodulation. These capabilities arose early in vertebrate evolution, preceding the evolution cerebellum jawed vertebrates. This later suggestive subsumption architecture that adds functionality to a pre-existing network. From central-pattern-generator perspective, what additional might provide? The suggestion adaptive filter may be able use error learning appropriately repurpose output. Examples include head eye stabilization during locomotion, song learning, context-dependent alternation between learnt motor-control sequences.

Language: Английский

Citations

4
Androgen receptors rapidly modulate non-breeding aggression in male and female weakly electric fish (Gymnotus omarorum) DOI

Guillermo Valiño,

Kent D. Dunlap, Laura Quintana

et al.

Hormones and Behavior, Journal Year: 2023, Volume and Issue: 159, P. 105475 - 105475

Published: Dec. 28, 2023

Language: Английский

Citations

3
Glutamatergic control of a pattern-generating central nucleus in a gymnotiform fish DOI
Virginia Comas, Michel Borde

Journal of Neurophysiology, Journal Year: 2021, Volume and Issue: 125(6), P. 2339 - 2355

Published: May 12, 2021

The activity of central pattern-generating networks (CPGs) may change under the control exerted by various neurotransmitters and modulators to adapt its behavioral outputs different environmental demands. Although mechanisms underlying this have been well established in invertebrates, most their synaptic cellular bases are not yet understood vertebrates. Gymnotus omarorum, a pulse-type gymnotiform electric fish, provides well-suited vertebrate model investigate these mechanisms. G. omarorum emits rhythmic stereotyped organ discharges (EODs), which function both perception communication, command an electromotor CPG. This nucleus is composed electrotonically coupled intrinsic pacemaker cells, pace rhythm, bulbospinal projecting relay cells that contribute organize pattern muscle-derived effector activation produce EOD. Descending influences target CPG neurons adaptive responses challenges. We used electrophysiological pharmacological techniques brainstem slices underpinnings fast transmitter demonstrate pacemaker, but endowed with ionotropic metabotropic glutamate receptor subtypes. also show glutamatergic likely involves two types synapses contacting one type containing α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) N-methyl-d-aspartate (NMDA) receptors other only-NMDA receptor. Fast neurotransmitter CPGs seems exploit kinetics involved postsynaptic outputs. prospect common neural designs vertebrates discussed.NEW & NOTEWORTHY Underpinnings neuromodulation (CPG) characterized many species. effects systems remain, however, poorly understood. research uses vitro fish convergence AMPA-NMDA onto rhythm. These inputs according distinct functional properties.

Language: Английский

Citations

4