CYTOLOGICAL CHARACTERISTICS OF THE WOUND HEALING PROCESS IN PATIENTS WITH CORONARY HEART DISEASE AT DIFFERENT STAGES OF THE POSTOPERATIVE PERIOD IN ODONTOGENIC PHLEGMON OF MAXILLOFACIAL LOCALIZATION DOI Open Access

A.V. Kiptiliy,

Давид Соломонович Аветіков

Актуальні проблеми сучасної медицини Вісник Української медичної стоматологічної академії, Journal Year: 2024, Volume and Issue: 24(4), P. 155 - 161

Published: Dec. 26, 2024

Odontogenic phlegmon of maxillofacial localisation is one the most common diseases in practice a dental surgeon. The presence comorbidities, such as coronary heart disease, can negatively impact course underlying condition, complicate diagnosis and treatment, delay patient recovery. This highlights need to explore improve treatment methods for odontogenic patients with disease. aim this study was examine dynamics regenerative processes wound at different stages postoperative period after using both classical novel localization artery Subjects methods. included 80 pathology, divided into 4 groups. In first group, quercetin added standard therapy, second mexazol were used, third group received treatment. Patients these three groups had history fourth (control) only disease without comorbidities. Cytological examination performed "surface biopsy" method. material collected on days 1, 3, 5, 7, 9 stained Romanowsky-Giemsa Subsequently, histological specimens examined. Results. On day main cellular elements across all erythrocytes. By lymphocytes single holonuclear cells observed group; precollagen fibers appeared showed significant number polymorphonuclear leukocytes; mainly cells. progressive development processes, while entered final phase regeneration. groups, gradual process observed. signs stage healing, completed process. point. 9, no inflammation present Conclusion. use combined intravenous injections part conservative therapy accelerates shortens duration inflammatory reaction.

Language: Английский

Targeting Mitochondrial Dysfunction in Cerebral Ischemia: Advances in Pharmacological Interventions DOI Creative Commons
И. Ф. Беленичев, Olena Popazova, Nina Bukhtiyarova

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(1), P. 108 - 108

Published: Jan. 18, 2025

The study of mitochondrial dysfunction has become increasingly pivotal in elucidating the pathophysiology various cerebral pathologies, particularly neurodegenerative disorders. Mitochondria are essential for cellular energy metabolism, regulation reactive oxygen species (ROS), calcium homeostasis, and execution apoptotic processes. Disruptions function, driven by factors such as oxidative stress, excitotoxicity, altered ion balance, lead to neuronal death contribute cognitive impairments several brain diseases. Mitochondrial can arise from genetic mutations, ischemic events, hypoxia, other environmental factors. This article highlights critical role progression diseases discusses need targeted therapeutic strategies attenuate damage, restore enhance neuroprotection.

Language: Английский

Citations

3
Effects of Different Shaping Methods and Loading on Fruit Quality and Volatile Compounds in ‘Beibinghong’ Grapes DOI Creative Commons
Yingxue Liu,

Weiyu Cao,

Baoxiang Zhang

et al.

Foods, Journal Year: 2025, Volume and Issue: 14(5), P. 772 - 772

Published: Feb. 24, 2025

The effects of different shaping methods and loading treatments on the photosynthetic rate, chlorophyll content, fruit yield quality, volatile compound composition 'Beibinghong' grape were studied. In experiment, 6-year-old grapes selected as material, two kinds adopted: double main vine upright tree (control) inclined horizontal dragon tree. was treated with loads. components in analyzed by gas chromatography-mass spectrometry (GC-MS). changes quality under multivariate statistics. results showed that significantly increased net rate content leaves, soluble sugar sugar-acid ratio fruits. better than vine. plants nine branches had higher yield, best performance reducing titrable acid ratio, which most suitable treatment. metabolomics study 291 metabolites identified, 25 considered to be key differential affecting flavor 'Beibing red' treatments. Further analysis draconite superior improving accumulation compounds fruit. This revealed regulation mechanism loads growth grapes, provided theoretical support for optimizing viticulture management market competitiveness.

Language: Английский

Citations

0
A Review of Hypoxen Pharmacology and Potential to Enhance Sports Performance DOI
Karol Jędrejko,

Oliver Catlin,

Raphaël Faiss

et al.

Drug Testing and Analysis, Journal Year: 2025, Volume and Issue: unknown

Published: April 13, 2025

ABSTRACT Pharmacological potential of Hypoxen, previously registered as Olifen is evaluated herein. Hypoxen categorized antihypoxic agent. The active substance polydihydroxyphenylene thiosulfonate sodium. Human studies are limited and no clinical trials following international standards available. There however a developed body knowledge emerging from original conducted by the Russian Military Medical Academy in 1980s 1990s despite online access. promoted to improve oxygen supply or reduce consumption under hypoxic conditions physical load. It thought support faster recovery, can be used complex treatments diseases accompanied hypoxia like myocardial ischemia. From perspective, it may enhance cellular respiration improving coupling respiratory chain/accelerating oxidative phosphorylation, but also inhibit succinate dehydrogenase (SDH), activate mitochondrial ATP‐sensitive potassium channels (mitoK ATP ) skeletal muscles myocardium. In 2023, World Anti‐Doping Agency (WADA) added Monitoring Program there had been documented evidence its use athletes. On vitro experiments compared influence on phosphorylation with uncoupling agent 2,4‐dinitrophenol (DNP) unique metabolic modulator that strongly accelerates metabolism rate, prohibited since 2024 WADA. Most focus exercise performance, provide some has first criteria considered for addition WADA Prohibited List. Pharmacodynamics ergogenic effects suggests modulator.

Language: Английский

Citations

0
Evaluation of the effectiveness of the drug cytoflavin to improve adaptation to physical activity in athletes with minor cardiac anomalies DOI
Владимир Станиславович Василенко, В.И. Орел, Ekaterina B. Karpovskaya

et al.

Russian Journal of Preventive Medicine, Journal Year: 2025, Volume and Issue: 28(5), P. 90 - 90

Published: May 27, 2025

Abjective. To establish the effectiveness of use cytoflavin drug to improve adaptation cardiovascular system basketball players with minor cardiac abnormalities sports exertions. Materials and methods. The study included 24 abnormalities. course administration at end run-in period was performed 12 players. At beginning year, 24-hour Holter monitoring carried out as part medical check-up. Signs overstrain were determined on basis detection clinically significant ventricular supraventricular extrasystoles. Content myocardial antigen, cortisol testosterone, total effective albumin, oxidized lipoproteins investigated in blood serum. Anabolic index, toxicity prevention coefficient calculated. Results. Minor have been revealed 45.3% It has established that pharmaceutical agent for reduction oxLDL oxidative stress marker amounted 83.3%, increase functional activity albumin serum — 42%, metabolic disorders predominance catabolic processes 80%; antigen 55.6%, extrasystoles 62.5%. Conclusions. Cytoflavin most pronounced potential athletes normalize ratio anabolic reduce stress. During cytoflavin, there is an training competition loads.

Language: Английский

Citations

0
QUALITATIVE AND QUANTITATIVE COMPOSITION OF THE MICROBIOTA IN ODONTOGENIC PHLEGMON IN PATIENTS WITH CORONARY HEART DISEASE DOI Open Access

A.V. Kiptiliy,

D.V. Steblovskiy,

V.O. Luchman

et al.

Актуальні проблеми сучасної медицини Вісник Української медичної стоматологічної академії, Journal Year: 2025, Volume and Issue: 25(2), P. 100 - 105

Published: May 29, 2025

Relevance. Odontogenic infections arise from the spread of pathogens originating in necrotic pulp due to complicated caries, periodontal pockets periodontitis, or pericoronitis associated with difficult eruption impacted teeth. These pathways confirm bacterial nature such conditions. The oral cavity hosts over 700 microbial species, many which may develop pathogenic potential under favorable presence comorbidities, as systemic diseases, can further contribute this shift. Objective: To identify qualitative and quantitative composition microbiota odontogenic phlegmon patients coronary heart disease. Participants methods. study involved 75 maxillofacial region concomitant disease, who were then divided into three groups based on type conservative treatment received. first group underwent standard protocol combination quercetin. second included received therapy addition quercetin ethylmethylhydroxypyridine succinate. third only according protocol. Results. phlegmon, total number microorganisms colonizing infection focus at time hospitalization, their changes course experiment determined. overall prevalence gram-positive cocci compared gram-negative bacteria was observed. Specifically, cocci, representatives genera Staphylococcus, Enterococcus, Kocuria, Streptococcus, identified disease 97.3% cases. Regarding assessment, it found that experienced an acceleration wound healing by average 2.3 days 1.9 group. Conclusions. Thus, succinate for comorbid demonstrates a positive effect colonization reduces required pathogen eradication.

Language: Английский

Citations

0
Acupoint catgut embedding attenuates oxidative stress and cognitive impairment in chronic cerebral ischemia by inhibiting the Ang II/AT1R/NOX axis DOI

Jurui Wei,

Qi Ai,

Peier Lv

et al.

Pflügers Archiv - European Journal of Physiology, Journal Year: 2024, Volume and Issue: 476(8), P. 1249 - 1261

Published: June 28, 2024

Language: Английский

Citations

0
CYTOLOGICAL CHARACTERISTICS OF THE WOUND HEALING PROCESS IN PATIENTS WITH CORONARY HEART DISEASE AT DIFFERENT STAGES OF THE POSTOPERATIVE PERIOD IN ODONTOGENIC PHLEGMON OF MAXILLOFACIAL LOCALIZATION DOI Open Access

A.V. Kiptiliy,

Давид Соломонович Аветіков

Актуальні проблеми сучасної медицини Вісник Української медичної стоматологічної академії, Journal Year: 2024, Volume and Issue: 24(4), P. 155 - 161

Published: Dec. 26, 2024

Odontogenic phlegmon of maxillofacial localisation is one the most common diseases in practice a dental surgeon. The presence comorbidities, such as coronary heart disease, can negatively impact course underlying condition, complicate diagnosis and treatment, delay patient recovery. This highlights need to explore improve treatment methods for odontogenic patients with disease. aim this study was examine dynamics regenerative processes wound at different stages postoperative period after using both classical novel localization artery Subjects methods. included 80 pathology, divided into 4 groups. In first group, quercetin added standard therapy, second mexazol were used, third group received treatment. Patients these three groups had history fourth (control) only disease without comorbidities. Cytological examination performed "surface biopsy" method. material collected on days 1, 3, 5, 7, 9 stained Romanowsky-Giemsa Subsequently, histological specimens examined. Results. On day main cellular elements across all erythrocytes. By lymphocytes single holonuclear cells observed group; precollagen fibers appeared showed significant number polymorphonuclear leukocytes; mainly cells. progressive development processes, while entered final phase regeneration. groups, gradual process observed. signs stage healing, completed process. point. 9, no inflammation present Conclusion. use combined intravenous injections part conservative therapy accelerates shortens duration inflammatory reaction.

Language: Английский

Citations

0