The
development
of
a
polarized
neuron
relies
on
the
selective
transport
proteins
to
axons
and
dendrites.
Although
it
is
well
known
that
microtubule
cytoskeleton
has
central
role
in
establishing
neuronal
polarity,
how
its
specific
organization
established
maintained
poorly
understood.
Using
vivo
model
system
Caenorhabditis
elegans,
we
found
highly
conserved
UNC-119
protein
provides
link
between
membrane-associated
Ankyrin
(UNC-44)
microtubule-associated
CRMP
(UNC-33).
Together
they
form
periodic
complex
anchors
axonal
dendritic
bundles
cortex.
This
anchoring
critical
maintain
by
opposing
kinesin-1
powered
sliding.
Disturbing
this
molecular
alters
polarity
causes
strong
developmental
defects
nervous
leading
severely
paralyzed
animals.
Frontiers in Aging Neuroscience,
Journal Year:
2019,
Volume and Issue:
11
Published: Aug. 7, 2019
Microtubules
(MTs)
play
a
fundamental
role
in
many
vital
processes
such
as
cell
division
and
neuronal
activity.
They
are
key
structural
functional
elements
axons,
supporting
neurite
differentiation
growth,
well
transport
along
the
axons
by
motor
proteins,
which
use
MTs
support
tracks.
Tau
is
stabilizing
MT
associated
protein,
whose
functions
mainly
regulated
phosphorylation.
A
disruption
of
network,
might
be
caused
loss
function,
observed
group
related
diseases
called
tauopathies,
includes
Alzheimer's
disease
(AD).
found
hyperphosphorylated
AD,
account
for
its
capacity.
Since
destabilization
after
dissociation
could
contribute
to
toxicity
neurodegenerative
diseases,
molecular
understanding
this
interaction
regulation,
essential.
International Journal of Molecular Sciences,
Journal Year:
2022,
Volume and Issue:
23(21), P. 12841 - 12841
Published: Oct. 25, 2022
Alzheimer’s
disease
(AD)
is
the
leading
cause
of
dementia
in
elderly
people.
Amyloid
beta
(Aβ)
deposits
and
neurofibrillary
tangles
are
major
pathological
features
an
brain.
These
proteins
highly
expressed
nerve
cells
found
most
tissues.
Tau
primarily
provides
stabilization
to
microtubules
part
axons
dendrites.
However,
tau
a
state
becomes
hyperphosphorylated,
causing
dysfunction
synaptic
impairment
degeneration
neurons.
This
article
presents
summary
role
tau,
phosphorylated
(p-tau)
AD,
other
tauopathies.
Tauopathies,
including
Pick’s
disease,
frontotemporal
dementia,
corticobasal
degeneration,
argyrophilic
grain
progressive
supranuclear
palsy,
Huntington’s
result
misprocessing
accumulation
within
neuronal
glial
cells.
also
focuses
on
current
research
post-translational
modifications
genetics
pathology,
tauopathies
development
new
drugs
targeting
p-tau,
therapeutics
for
treating
possibly
preventing
Cells,
Journal Year:
2021,
Volume and Issue:
10(4), P. 721 - 721
Published: March 24, 2021
Glycogen
synthase
kinase-3
(GSK-3)
is
a
ubiquitously
expressed
serine/threonine
kinase
with
plethora
of
substrates.
As
modulator
several
cellular
processes,
GSK-3
has
central
position
in
cell
metabolism
and
signaling,
important
roles
both
physiological
pathological
conditions.
been
associated
number
human
disorders,
such
as
neurodegenerative
diseases
including
Alzheimer's
disease
(AD).
contributes
to
the
hyperphosphorylation
tau
protein,
main
component
neurofibrillary
tangles
(NFTs),
one
hallmarks
AD.
further
involved
regulation
different
neuronal
processes
that
are
dysregulated
during
AD
pathogenesis,
generation
amyloid-β
(Aβ)
peptide
or
Aβ-induced
death,
axonal
transport,
cholinergic
function,
adult
neurogenesis
synaptic
function.
In
this
review,
we
will
summarize
recent
data
about
involvement
these
contributing
pathology,
mostly
focusing
on
crucial
interplay
between
protein.
We
discuss
current
development
potential
therapies
targeting
GSK-3-phosphorylated
tau.
Biomedicine & Pharmacotherapy,
Journal Year:
2019,
Volume and Issue:
121, P. 109670 - 109670
Published: Nov. 22, 2019
Berberine
is
a
natural
isoquinoline
alkaloid
isolated
from
the
Rhizoma
coptidis.
Recent
advances
in
research
throw
more
lights
of
its
beneficial
role
towards
Alzheimer's
disease
(AD),
including
promoting
β-amyloid
(Aβ)
clearance,
as
well
inhibiting
Aβ
production
triple-transgenic
mouse
model
(3×Tg
AD).
However,
it
remains
unclarified
if
berberine
has
an
effect
on
tau
pathology.
According
to
our
study,
did
not
only
significantly
improve
3×Tg
AD
mice's
spatial
learning
capacity
and
memory
retentions,
but
also
attenuated
hyperphosphorylation
tau.
via
modulating
activity
Akt/glycogen
synthase
kinase-3β
protein
phosphatase
2A.
Moreover,
reduced
level
through
autophagy-based
route.
It
promoted
autophagic
clearance
by
enhancing
autophagy
class
III
PI3K/beclin-1
pathway.
Thus,
results
suggest
that
could
mitigate
cognitive
decline
simultaneously
targeting
mice.
These
findings
strongly
support
potential
drug
candidate
for
AD.
Current Opinion in Neurobiology,
Journal Year:
2019,
Volume and Issue:
57, P. 39 - 45
Published: Feb. 10, 2019
Neurons
are
exquisitely
polarized
cells
whose
structure
and
function
relies
on
microtubules.
Microtubules
in
signal-receiving
dendrites
signal-sending
axons
differ
their
organization
microtubule-associated
proteins.
These
differences,
coupled
with
microtubule
post-translational
modifications,
combine
to
locally
regulate
intracellular
transport,
morphology,
function.
Recent
discoveries
provide
new
insight
into
the
regulation
of
non-centrosomal
arrays
neurons,
relationship
between
acetylation
mechanosensation,
spatial
patterning
microtubules
that
regulates
motor
activity
cargo
delivery
dendrites.
Together,
these
studies
bring
us
closer
understanding
how
is
tuned
match
specialized
tasks
associated
signal
reception
transmission.
