Role of natural products for the treatment of Alzheimer's disease

European Journal of Pharmacology, Journal Year: 2021, Volume and Issue: 898, P. 173974 - 173974

Published: Feb. 27, 2021

Language: Английский

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Impairment of the autophagy–lysosomal pathway in Alzheimer's diseases: Pathogenic mechanisms and therapeutic potential

Acta Pharmaceutica Sinica B, Journal Year: 2022, Volume and Issue: 12(3), P. 1019 - 1040

Published: Jan. 21, 2022

Alzheimer's disease (AD), the most common neurodegenerative disorder, is characterized by memory loss and cognitive dysfunction. The accumulation of misfolded protein aggregates including amyloid beta (Aβ) peptides microtubule associated tau (MAPT/tau) in neuronal cells are hallmarks AD. So far, exact underlying mechanisms for aetiologies AD have not been fully understood effective treatment limited. Autophagy an evolutionarily conserved cellular catabolic process which damaged organelles degraded via lysosomes. Recently, there accumulating evidence linking impairment autophagy-lysosomal pathway with pathogenesis. Interestingly, enhancement autophagy to remove has proposed as a promising therapeutic strategy Here, we first summarize recent genetic, pathological experimental studies regarding We then describe interplay between two proteins, Aβ MAPT/tau, Finally, discuss potential strategies small molecules that target both animal models clinical trials. Overall, this article highlights pivotal functions pathogenesis druggable targets treatment.

Language: Английский

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Signal pathways in the treatment of Alzheimer’s disease with traditional Chinese medicine

Biomedicine & Pharmacotherapy, Journal Year: 2022, Volume and Issue: 152, P. 113208 - 113208

Published: May 31, 2022

This study aimed to reveal the classical signal pathways and important potential targets of traditional Chinese medicine (TCM) for treating Alzheimer's disease (AD), provide support further investigation on TCM its active ingredients.Literature survey was conducted using PubMed, Web Science, Google Scholar, CNKI, other databases, with "Alzheimer's disease," "traditional medicine," "medicinal herb," "Chinese "natural plant" as primary keywords.TCM could modulate related AD pathological progression, including NF-κB, Nrf2, JAK/STAT, ubiquitin-proteasome pathway, autophagy-lysosome pathway-related AMPK/mTOR, GSK-3/mTOR, PI3K/Akt/mTOR, well SIRT1 PPARα pathway. It regulate crosstalk between through a multitarget, thus maintaining chronic inflammatory interaction balance, inhibiting oxidative stress damage, regulating system function, modulating autophagy, eventually improving cognitive impairment in patients AD.TCM be multilevel, multitargeted, multifaceted prevent treat AD. In-depth research prevention treatment new ideas exploring pathogenesis developing anti-AD drugs.

Language: Английский

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Enhancing autophagy in Alzheimer's disease through drug repositioning

Pharmacology & Therapeutics, Journal Year: 2022, Volume and Issue: 237, P. 108171 - 108171

Published: March 16, 2022

Language: Английский

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Berberine ameliorates iron levels and ferroptosis in the brain of 3 × Tg-AD mice

Phytomedicine, Journal Year: 2023, Volume and Issue: 118, P. 154962 - 154962

Published: July 17, 2023

Language: Английский

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Advancing green extraction of bioactive compounds using deep eutectic solvent-based ultrasound-assisted matrix solid-phase dispersion: Application to UHPLC-PAD analysis of alkaloids and organic acids in Coptidis rhizoma

Talanta, Journal Year: 2024, Volume and Issue: 274, P. 125983 - 125983

Published: March 22, 2024

Language: Английский

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Brain-targeted Tet-1 peptide-PLGA nanoparticles for berberine delivery against STZ-induced Alzheimer’s disease in a rat model: Alleviation of hippocampal synaptic dysfunction, Tau pathology, and amyloidogenesis

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 658, P. 124218 - 124218

Published: May 9, 2024

Language: Английский

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Advancements in autophagy perturbations in Alzheimer’s disease: Molecular aspects and therapeutics

Brain Research, Journal Year: 2025, Volume and Issue: 1851, P. 149494 - 149494

Published: Feb. 6, 2025

Language: Английский

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Transcription factor NRF2 as a promising therapeutic target for Alzheimer’s disease

Free Radical Biology and Medicine, Journal Year: 2020, Volume and Issue: 159, P. 87 - 102

Published: July 28, 2020

Language: Английский

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Natural Compounds and Autophagy: Allies Against Neurodegeneration

Frontiers in Cell and Developmental Biology, Journal Year: 2020, Volume and Issue: 8

Published: Sept. 22, 2020

Prolonging the healthy life span and limiting neurological illness are imperative goals in gerontology. Age-related neurodegeneration is progressive leads to severe diseases affecting motility, memory, cognitive function, social life. To date, no effective treatments available for irreversible neuronal loss. Bioactive phytochemicals could represent a natural alternative ensure active aging slow onset of neurodegenerative elderly patients. Autophagy or macroautophagy an evolutionarily conserved clearing process that needed remove aggregate-prone proteins organelles neurons glia. It also crucial synaptic plasticity. Aberrant autophagy has key role neurodegeneration. Recent evidence indicates polyphenols like resveratrol curcumin, flavonoids, quercetin, polyamine, spermidine sugars, trehalose, limit brain damage vitro vivo. Their common mechanism action restoration efficient by dismantling misfolded dysfunctional mitochondria. This review focuses on dietary as modulators fight Alzheimer's Parkinson's diseases, fronto-temporal dementia, amyotrophic lateral sclerosis, psychiatric disorders. Currently, most studies have involved preclinical animal models, therapeutic use patients remains limited.

Language: Английский

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