Maternal deposition of hormones and contaminants shape the gonadal transcriptome in American alligators DOI
Christopher R. Smaga, Samantha L. Bock, Josiah M. Johnson

et al.

Proceedings of the Royal Society B Biological Sciences, Journal Year: 2025, Volume and Issue: 292(2039)

Published: Jan. 1, 2025

Environmental conditions influence the maternal deposition of hormones into eggs, which is hypothesized to adaptively modify developmental outcomes in offspring. However, most ecosystems harbour environmental contaminants capable disrupting endocrine signaling, and exposure these compounds has potential further alter offspring traits. Studies rarely examine maternally derived along with phenotypes, we know little about their interrelationships interactions. Here, measure yolk concentrations 24 endocrine-disrupting (EDCs) 28 steroid gonadal transcriptomes from two populations American alligator (Alligator mississippiensis) that differ reproductive development EDCs. Using a network-based approach, identify gene expression modules associated independently, combination, or by indirect influences EDCs on hormone deposition. We find both 17β-oestradiol etiocholanolone across explain substantial variation expression. provide evidence for effect pesticide, methoxychlor, through its relationship 17β-oestradiol. Our results reveal novel pathways interacts provisioning affect sexual development.

Language: Английский

Potential Implications of Acid-Sensing Ion Channels ASIC2 and ASIC4 in Gonadal Differentiation of Dicentrarchus labrax Subjected to Water Temperature Increase during Gonadal Development DOI Creative Commons
Kamel Mhalhel, Rosaria Arena, Maria Antonietta Rizzo

et al.

Animals, Journal Year: 2024, Volume and Issue: 14(7), P. 1024 - 1024

Published: March 27, 2024

In this study, the expression and implication of acid-sensing ion channels 2 4 (ASIC2 ASIC4) in gonadal sex differentiation Dicentrarchus labrax (D. labrax), subjected to increasing water temperatures during development, were evaluated. Two groups selected: a control group (CG), which average temperature was maintained at 15 °C increased 20 days until weaning; an experimental (EG), retained for 60 days; thereafter, daily by 0.5 it reached up weaning time. Ten fish from CG 13 EG sampled randomly on 335th day after hatching (dph). A higher percentage gonad ovaries rather than testes observed compared (p = 0.01). ASIC2 ASIC4 detected first time D. indirect immunofluorescence. Both expressed previtellogenic oocytes scattered cells within some testes, most likely intratesticular both groups. The showed cohort < 0.05). results gathered study revealed capacity influence growth gonochoristic species, suggests possible role gamete development labrax.

Language: Английский

Citations

4
The influence of incubation temperature on offspring traits varies across northern and southern populations of the American alligator (Alligator mississippiensis) DOI Creative Commons
Christopher R. Smaga, Samantha L. Bock, Josiah M. Johnson

et al.

Ecology and Evolution, Journal Year: 2024, Volume and Issue: 14(2)

Published: Feb. 1, 2024

Maternal provisioning and the developmental environment are fundamental determinants of offspring traits, particularly in oviparous species. However, extent to which embryonic responses these factors differ across populations drive phenotypic variation is not well understood. Here, we examine contributions maternal incubation temperature hatchling morphological metabolic traits four American alligator (

Language: Английский

Citations

3
Maternal deposition of hormones and contaminants shape the gonadal transcriptome in American alligators DOI
Christopher R. Smaga, Samantha L. Bock, Josiah M. Johnson

et al.

Proceedings of the Royal Society B Biological Sciences, Journal Year: 2025, Volume and Issue: 292(2039)

Published: Jan. 1, 2025

Environmental conditions influence the maternal deposition of hormones into eggs, which is hypothesized to adaptively modify developmental outcomes in offspring. However, most ecosystems harbour environmental contaminants capable disrupting endocrine signaling, and exposure these compounds has potential further alter offspring traits. Studies rarely examine maternally derived along with phenotypes, we know little about their interrelationships interactions. Here, measure yolk concentrations 24 endocrine-disrupting (EDCs) 28 steroid gonadal transcriptomes from two populations American alligator (Alligator mississippiensis) that differ reproductive development EDCs. Using a network-based approach, identify gene expression modules associated independently, combination, or by indirect influences EDCs on hormone deposition. We find both 17β-oestradiol etiocholanolone across explain substantial variation expression. provide evidence for effect pesticide, methoxychlor, through its relationship 17β-oestradiol. Our results reveal novel pathways interacts provisioning affect sexual development.

Language: Английский

Citations

0