Medical Molecular Morphology, Journal Year: 2024, Volume and Issue: 57(3), P. 161 - 166
Published: July 9, 2024
Language: Английский
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(7), P. 3694 - 3694
Published: March 26, 2024
Metabolic-associated fatty liver disease (MAFLD) includes several metabolic dysfunctions caused by dysregulation in the brain–gut–liver axis and, consequently, increases cardiovascular risks and dysfunction. In MAFLD, type 2 diabetes mellitus, obesity, syndrome are frequently present; these conditions related to lipogenesis systemic inflammation. This study aimed review connection between MAFLD. The inflammatory process, cellular alterations hepatocytes stellate cells, hypercaloric diet, sedentarism aggravate prognosis of patients with Thus, understand modulation physiopathology it is necessary include organokines involved this process (adipokines, myokines, osteokines, hepatokines) their clinical relevance project future perspectives condition bring light new possibilities therapeutic approaches. Adipokines responsible for activation distinct signaling different tissues, such as insulin pro-inflammatory cytokines, which important balancing substances avoid MAFLD its progression. Myokines improve quantity quality adipose contributing avoiding development Finally, hepatokines decisive improving or not progression through regulation anti-inflammatory organokines.
Language: Английский
Citations
15
Nature Immunology, Journal Year: 2024, Volume and Issue: 25(6), P. 981 - 993
Published: May 29, 2024
Language: Английский
Citations
8
European Journal of Clinical Investigation, Journal Year: 2024, Volume and Issue: 54(11)
Published: June 28, 2024
Abstract Background and Aims The rise in obesity highlights the need for improved therapeutic strategies, particularly addressing metabolic dysfunction‐associated steatotic liver disease (MASLD). We aim to assess role of tryptophan pathways pathogenesis different histological stages MASLD. Materials Methods used ultra‐high performance liquid chromatography quantify circulating levels 15 tryptophan‐related metabolites from kynurenine, indole serotonin pathways. A cohort 76 subjects was analysed, comprising 18 with normal weight 58 morbid obesity, these last being subclassified into (NL), simple steatosis (SS) steatohepatitis (MASH). Then, we conducted gene expression analysis hepatic IDO‐1 kynyrenine‐3‐monooxygenase (KMO). Results Key findings revealed a distinct signature characterized by higher concentration kynurenine‐related metabolites, decrease indole‐3‐acetic acid indole‐3‐propionic acid, an alteration pathway. Elevated were associated MASLD presence (37.659 (32.577–39.823) μM NL subjects; 41.522 (38.803–45.276) patients MASLD). Overall, pathway fluxes demonstrated induction catabolism via SS kynurenine MASH. found decreased KMO compared SS. Conclusions identified distinctive marked changes catabolic pathways, discernible through altered metabolite profiles. observed stage‐specific alterations MASLD, highlighting potential utility targeting interventions.
Language: Английский
Citations
6
Biomolecules & Therapeutics, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 20, 2024
AMP-activated protein kinase (AMPK) activators have garnered significant attention for their potential to prevent the progression of metabolic dysfunction-associated steatotic liver disease (MASLD) into fibrosis and fundamentally improve function. The broad spectrum pathways regulated by AMPK makes them promising alternatives conventional replacement therapies limited pharmacological treatments currently available. In this study, we aim illustrate newly detailed multiple mechanisms MASLD based on multiple-hit hypothesis. This model posits that impaired lipid metabolism, combined with insulin resistance imbalance, initiates inflammatory cascades, gut dysbiosis, accumulation toxic metabolites, ultimately promoting accelerating irreversible hepatocellular carcinoma (HCC). plays a multifaceted protective role against these pathological conditions regulating several key downstream signaling pathways. It regulates biological effectors critical responses, such as SIRT1, Nrf2, mTOR, TGF-β, through complex interrelated mechanisms. Due intricate connections, AMPK's is pivotal in managing disorders. review, demonstrate specific roles its related Several agents directly activate binding agonists, while some others indirectly modulating upstream molecules, including adiponectin, LKB1, AMP: ATP ratio. As can target each stage progression, development offers immense expand therapeutic strategies diseases MASH, MASLD, fibrosis.
Language: Английский
Citations
5
Cellular and Molecular Immunology, Journal Year: 2024, Volume and Issue: 21(9), P. 1051 - 1065
Published: Aug. 6, 2024
Everyone knows that an infection can make you feel sick. Although we perceive infection-induced changes in metabolism as a pathology, they are part of carefully regulated process depends on tissue-specific interactions between the immune system and organs involved regulation systemic homeostasis. Immune-mediated homeostatic parameters lead to altered production uptake nutrients circulation, which modifies metabolic rate key organs. This is what experience being The purpose sickness generate environment body optimally able fight while denying vital for replication pathogens. Sickness cells, mediate responses tailored nature magnitude threat. As increases severity, so do number type cells level affected, dictates degree Interestingly, many alterations associated with disease appear overlap immune-mediated observed following infection. Targeting processes involving activated therefore holds great potential treating both people severe those disease. In this review, will discuss how communicates situ homeostasis communication impacted by
Language: Английский
Citations
4
Deleted Journal, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 28, 2025
Citations
0
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 2837 - 2837
Published: March 21, 2025
There is a significant, rather than just anecdotal, connection between the liver and eyes. This evident in noticeable cases such as jaundice, where sclera has yellow tint. But this can be seen through even more subtle indicators, molecules known hepatokines. relationship not merely anecdotal; some studies, it referred to “liver–eye axis”. Ubiquitous environmental contaminants, microplastics (MPs), enter bloodstream human body conjunctival sac, nasolacrimal duct, upper respiratory tract mucosa. Once absorbed, these substances accumulate various organs cause harm. Toxic from surface of eye lead local oxidative damage by inducing apoptosis corneal cells, irregularly shaped microparticles exacerbate effect. Even other toxicants ocular may absorbed into distributed throughout body. Environmental toxicology presents challenge because many pollutants same route that used certain medications. Previous research indicated accumulation MPs play major role development chronic disease humans. It crucial investigate whether buildup potential fibrosis, or simply consequence conditions cirrhosis portal hypertension.
Language: Английский
Citations
0
World Journal of Hepatology, Journal Year: 2025, Volume and Issue: 17(3)
Published: March 25, 2025
The interplay between immune cells and metabolic associated fatty liver disease (MAFLD) is a critical research frontier, bridging immunology hepatology. bibliometric findings can guide future funding priorities in the field by highlighting key areas of focus potential therapeutic targets. To analyze literature on MAFLD, identifying trends hotspots. A systematic search Web Science Core Collection from January 1, 2004 to May 20, 2024, yielded 1936 articles MAFLD. Excluding non-research documents, data were analyzed using R packages Cluster profiler, enrichplot, ggplot2, VOSviewer CiteSpace. Visualizations created for countries, institutions, authors, journals, fields, co-cited references, keywords, genes, diseases, with gene Citexs. gained momentum 2006, United States America China as leading contributors. Key themes included oxidative stress, syndrome, fibrosis, role Kupffer cells. Bioinformatics identified interleukin-6, tumor necrosis factor signal transducer activator transcription 3 central proteins responses inflammation, suggesting targets Clinically, these hub genes play pivotal roles pathogenesis For instance, targeting signaling pathway could reduce while modulating interleukin-6 expression may improve function, offering new strategies MAFLD therapy. This analysis reports hotspots emerging through bioinformatics.
Language: Английский
Citations
0
Trends in Endocrinology and Metabolism, Journal Year: 2025, Volume and Issue: unknown
Published: April 1, 2025
Language: Английский
Citations
0
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(9), P. 4077 - 4077
Published: April 25, 2025
The recent introduction of the term metabolic-dysfunction-associated steatotic liver disease (MASLD) has highlighted critical role metabolism in disease’s pathophysiology. This innovative nomenclature signifies a shift from previous designation non-alcoholic fatty (NAFLD), emphasizing condition’s progressive nature. Simultaneously, MASLD become one most prevalent diseases worldwide, highlighting urgent need for research to elucidate its etiology and develop effective treatment strategies. review examines delineates revised definition MASLD, exploring epidemiology pathological changes occurring at various stages disease. Additionally, it identifies metabolically relevant targets within provides summary latest targeted drugs under development, including those clinical some preclinical stages. finishes with look ahead future therapy goal summarizing providing fresh ideas insights.
Language: Английский
Citations
0