PANoptosis: Novel insight into regulated cell death and its potential role in cardiovascular diseases (Review) DOI Creative Commons
Xinyu Gao,

Cuixue Ma,

Shan Liang

et al.

International Journal of Molecular Medicine, Journal Year: 2024, Volume and Issue: 54(3)

Published: July 4, 2024

PANoptosis, a complex form of proinflammatory programmed cell death, including apoptosis, pyroptosis and necroptosis, has been an emerging concept in recent years that widely reported cancer, infectious diseases neurological disorders. Cardiovascular (CVDs) are important global health problem, posing serious threat to individuals' lives. An increasing body research shows inflammation pivotal role CVDs, which provides theoretical basis for PANoptosis promote the progression CVDs. To date, only sporadic studies on CVDs have its field not fully explored. Elucidating various modes cardiomyocyte specific molecular mechanisms links among death under stressful stimuli is notable clinical significance deeper understanding pathophysiology The present review summarizes pyroptosis, necroptosis their prospects

Language: Английский

Sensing of mitochondrial DNA by ZBP1 promotes RIPK3-mediated necroptosis and ferroptosis in response to diquat poisoning DOI

Kunmei Lai,

Junjie Wang,

Siyi Lin

et al.

Cell Death and Differentiation, Journal Year: 2024, Volume and Issue: 31(5), P. 635 - 650

Published: March 16, 2024

Language: Английский

Citations

15
New insights into nucleic acid sensor AIM2: The potential benefit in targeted therapy for cancer DOI Creative Commons
Jianzhou Cui,

Zhi Huan Chew,

Lina H. K. Lim

et al.

Pharmacological Research, Journal Year: 2024, Volume and Issue: 200, P. 107079 - 107079

Published: Jan. 24, 2024

The AIM2 inflammasome represents a multifaceted oligomeric protein complex within the innate immune system, with capacity to perceive double-stranded DNA (dsDNA) and engage in diverse physiological reactions disease contexts, including cancer. While originally conceived as discerning sensor, has demonstrated its capability discern various nucleic acid variations, encompassing RNA DNA-RNA hybrids. Through interaction acids, orchestrates assembly of involving multiple proteins, aptly named inflammasome, which facilitates enzymatic cleavage proinflammatory cytokines, namely pro-IL-1β pro-IL-18. This process, turn, underpins pivotal biological role. In this review, we provide systematic summary discussion latest advancements sensing types acids. Additionally, discuss modulation activation, can cause cell death, pyroptosis, apoptosis, autophagic death. Finally, fully illustrate evidence for dual role different cancer types, both anti-tumorigenic pro-tumorigenic functions. Considering above information, uncover therapeutic promise modulating treatment.

Language: Английский

Citations

11
Z-DNA binding protein 1 orchestrates innate immunity and inflammatory cell death DOI
Qixiang Song, Yuhang Fan, Huali Zhang

et al.

Cytokine & Growth Factor Reviews, Journal Year: 2024, Volume and Issue: 77, P. 15 - 29

Published: March 26, 2024

Language: Английский

Citations

11
Exploration of the mode of death and potential death mechanisms of nucleus pulposus cells DOI

Daqian Zhou,

Yongliang Mei,

Chao Song

et al.

European Journal of Clinical Investigation, Journal Year: 2024, Volume and Issue: 54(9)

Published: April 17, 2024

Intervertebral disc degeneration (IVDD) is a common chronic orthopaedic disease in orthopaedics that imposes heavy economic burden on people and society. Although it well established IVDD associated with genetic susceptibility, ageing obesity, its pathogenesis remains incompletely understood. Previously, was thought to occur because of excessive mechanical loading leading destruction nucleus pulposus cells (NPCs), but studies have shown much more complex process inflammation, metabolic factors NPCs death can involve all parts the disc, characterized by causing extracellular matrix (ECM) degradation. The damage pattern like some programmed cell death, suggesting death. apoptosis pyroptosis been studied IVDD, intervertebral still not be fully elucidated using only traditional modalities. With increasing research, new modes PANoptosis, ferroptosis senescence found closely related degeneration. Among these, PANoptosis combines essential elements pyroptosis, necroptosis form highly coordinated dynamically balanced inflammatory process. Furthermore, we believe may also crosstalk senescence. Therefore, review progress research multiple deaths provide guidance for clinical treatment.

Language: Английский

Citations

11
The protein phosphatase PP6 promotes RIPK1-dependent PANoptosis DOI Creative Commons
Ratnakar R. Bynigeri, R. K. Subbarao Malireddi, Raghvendra Mall

et al.

BMC Biology, Journal Year: 2024, Volume and Issue: 22(1)

Published: May 28, 2024

The innate immune system serves as the first line of host defense. Transforming growth factor-β-activated kinase 1 (TAK1) is a key regulator immunity, cell survival, and cellular homeostasis. Because its importance in several pathogens have evolved to carry TAK1 inhibitors. In response, hosts sense inhibition induce robust lytic death, PANoptosis, mediated by RIPK1-PANoptosome. PANoptosis unique inflammatory death pathway initiated an sensor driven caspases RIPKs. While can be beneficial clear pathogens, excess activation linked pathology. Therefore, understanding molecular mechanisms regulating inhibitor (TAK1i)-induced central our RIPK1 health disease.

Language: Английский

Citations

11
Emerging role of PANoptosis in kidney diseases: molecular mechanisms and therapeutic opportunities DOI
Yiping Hou, Qi Feng,

Cien Wei

et al.

APOPTOSIS, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 20, 2025

Language: Английский

Citations

1
PANoptosis: Mechanism and Role in Pulmonary Diseases DOI Open Access
Shiyi Chen, Jiacheng Jiang, Tongfu Li

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(20), P. 15343 - 15343

Published: Oct. 19, 2023

PANoptosis is a newly defined programmed cell death (PCD) triggered by series of stimuli, and it engages three well-learned PCD forms (pyroptosis, apoptosis, necroptosis) concomitantly. Normally, recognized as strategy to eliminate unnecessary cells, inhibit the proliferation invaded pathogens maintain homeostasis; however, vigorous can cause excessive inflammation tissue damage. Acute lung injury (ALI) chronic obstructive pulmonary syndrome (COPD) exacerbation related several (e.g., influenza A virus, SARS-CoV-2) known PANoptosis. An understanding mechanism specific regulators may help address pathological systems these diseases. This review presents our potential role in different

Language: Английский

Citations

19
COVID-19 patients with high TNF/IFN-γ levels show hallmarks of PANoptosis, an inflammatory cell death DOI Creative Commons
Yadira Palacios, Lucero A. Ramón‐Luing, Andy Ruíz

et al.

Microbes and Infection, Journal Year: 2023, Volume and Issue: 25(8), P. 105179 - 105179

Published: July 1, 2023

TNF and IFN-γ trigger cell damage during SARS CoV-2 infection; these cytokines can induce senescence a death process called PANoptosis. This study included 138 vaccine-naïve COVID-19 patients, who were divided into four groups (Gp) according to the plasma level of (High [

Language: Английский

Citations

17
Zinc ions regulate mitochondrial quality control in neurons under oxidative stress and reduce PANoptosis in spinal cord injury models via the Lgals3-Bax pathway DOI

Mingyu Bai,

Yang Cui,

Zelin Sang

et al.

Free Radical Biology and Medicine, Journal Year: 2024, Volume and Issue: 221, P. 169 - 180

Published: May 21, 2024

Language: Английский

Citations

7
Characterization of PANoptosis-related genes in Crohn’s disease by integrated bioinformatics, machine learning and experiments DOI Creative Commons
Yang Yang, Alphonse Houssou Hounye, Yiqian Chen

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: May 22, 2024

Currently, the biological understanding of Crohn's disease (CD) remains limited. PANoptosis is a revolutionary form cell death reported to participate in numerous diseases, including CD. In our study, we aimed uncover roles Differentially expressed PANoptosis-related genes (DE-PRGs) were identified by overlapping and differentially between CD normal samples combined microarray dataset. Three machine learning algorithms adopted detect hub DE-PRGs. To stratify heterogeneity within patients, nonnegative matrix factorization clustering was conducted. terms immune landscape analysis, "ssGSEA" method applied. qRT-PCR performed examine expression levels DE-PRGs patients colitis model mice. Ten with satisfactory diagnostic performance validated: CD44, CIDEC, NDRG1, NUMA1, PEA15, RAG1, S100A8, S100A9, TIMP1 XBP1. These displayed significant associations certain types CD-related genes. We also constructed gene‒microRNA, gene‒transcription factor drug‒gene interaction networks. classified into two patterns according Our results suggest that plays nonnegligible role modulating system interacting

Language: Английский

Citations

6