Recent progress in non-native nucleic acid modifications

Chemical Society Reviews, Journal Year: 2021, Volume and Issue: 50(8), P. 5126 - 5164

Published: Jan. 1, 2021

While Nature harnesses RNA and DNA to store, read write genetic information, the inherent programmability, synthetic accessibility wide functionality of these nucleic acids make them attractive tools for use in a vast array applications.

Language: Английский

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Ball milling: an efficient and green approach for asymmetric organic syntheses

Green Chemistry, Journal Year: 2019, Volume and Issue: 22(2), P. 302 - 315

Published: Dec. 23, 2019

Mechanochemical approaches in an organic synthesis have received increased interest because of their wide applications green methodologies.

Language: Английский

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Mechanochemistry: an efficient and versatile toolbox for synthesis, transformation, and functionalization of porous metal–organic frameworks

CrystEngComm, Journal Year: 2020, Volume and Issue: 22(27), P. 4511 - 4525

Published: Jan. 1, 2020

Multiple ways in which the synergy of mechanochemistry and MOFs advances field materials chemistry are presented here.

Language: Английский

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Mechanochemical and Mechanoenzymatic Synthesis of Pharmacologically Active Compounds: A Green Perspective

ACS Sustainable Chemistry & Engineering, Journal Year: 2020, Volume and Issue: 8(24), P. 8881 - 8893

Published: June 10, 2020

Recently, the application of mechanochemical strategies in organic synthesis has attracted attention both academic and industrial chemical communities. The high efficiency low environmental impact processes performed by mechanical activation positioned methods among salient green techniques since it allows accomplishment most sustainable chemistry principles. In particular, mechanochemistry been used as a tool for active pharmaceutical ingredients via or through biocatalytic protocols using enzymes with outstanding results, while simultaneously increasing sustainability process. this regard, main purpose present perspective is to summarize current developments mechanoenzymatic approaches pharmacologically compounds. importance these so-called medicinal field will be highlighted.

Language: Английский

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Green metrics in mechanochemistry

Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 52(19), P. 6680 - 6714

Published: Jan. 1, 2023

The quantitative assessment of the greenness mechanochemical processes for green metrics were calculated is herein reported. A general introduction to topic, variables influencing reaction outcome and, an outlook are also provided.

Language: Английский

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Outstanding Advantages, Current Drawbacks, and Significant Recent Developments in Mechanochemistry: A Perspective View

Crystals, Journal Year: 2023, Volume and Issue: 13(1), P. 124 - 124

Published: Jan. 10, 2023

Although known since antiquity, mechanochemistry has remained dormant for centuries. Nowadays, is a flourishing research field at the simultaneous stages of gathering data and (often astonishing) observations, scientific argumentation toward their analysis, which combination interdisciplinary expertise necessary. Mechanochemistry’s implementation as synthetic method constantly increasing, although it remains far from being fully exploited, or understood on basis fundamental principles. This review starts by describing many remarkable advantages mechanochemical reactions, simplifying “greening” chemistry in solutions. description followed an overview current main weaknesses to be addressed near future systematic study its energetics chemical mechanisms. finishes recent breakthrough experimental advances, such situ kinetics monitoring using synchrotron X-ray powder diffraction Raman spectroscopy, plus equally significant computational approaches, quantum mechanochemistry, used understanding covalent hydrogen bond ruptures biomolecules mechanophores polymers single-molecule level. Combined with new technologies control temperature pressure ball mills, these appealing methods are promising tools establishing knowledge necessary reactivity

Language: Английский

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Mechanochemical Approach for Air‐Tolerant and Extremely Fast Lithium‐Based Birch Reductions in Minutes

Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 62(21)

Published: March 22, 2023

Birch reduction has been widely used in organic synthesis for over half a century as powerful method to dearomatize arenes into 1,4-cyclohexadiene derivatives. However, the conventional reaction using liquid ammonia requires laborious procedures ensure inert conditions and low temperatures. Although several ammonia-free modifications have reported, development of an operationally simple, efficient, scalable protocol remains challenge. Herein, we report lithium-based air without special operating ball-milling technique. This is characterized by its operational simplicity extremely short time (within 1 min), probably owing situ mechanical activation lithium metal, broad substrate scope, no requirement dry bulk solvents. The potential our flash also demonstrated efficient bioactive target molecules gram-scale synthesis.

Language: Английский

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Beyond Solvothermal: Alternative Synthetic Methods for Covalent Organic Frameworks

Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 62(37)

Published: June 2, 2023

Abstract Covalent organic frameworks (COFs) are crystalline porous materials that hold a wealth of potential applications across various fields. The development COFs, however, is significantly impeded by the dearth efficient synthetic methods. traditional solvothermal approach, while prevalent, fraught with challenges such as complicated processes, excessive energy consumption, long reaction times, and limited scalability, rendering it unsuitable for practical applications. quest simpler, quicker, more energy‐efficient, environmentally benign strategies thus paramount bridging gap between academic COF chemistry industrial application. This Review provides an overview recent advances in alternative methods, particular emphasis on input. We discuss representative examples synthesis facilitated microwave, ultrasound, mechanic force, light, plasma, electric field, electron beam. Perspectives advantages limitations these methods against approach highlighted.

Language: Английский

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Unveiling the Potential of Covalent Organic Frameworks for Energy Storage: Developments, Challenges, and Future Prospects

Advanced Energy Materials, Journal Year: 2024, Volume and Issue: 14(24)

Published: May 1, 2024

Abstract Covalent organic frameworks (COFs) are porous structures emerging as promising electrode materials due to their high structural diversity, controlled and wide pore network, amenability chemical modifications. COFs solely composed of periodically arranged molecules, resulting in lightweight materials. Their inherent properties, such extended surface area diverse framework topologies, along with proclivity modification, have positioned sophisticated the realm electrochemical energy storage (EES). The modular structure facilitates integration key functions redox‐active moieties, fast charge diffusion channels, composite formation conductive counterparts, highly network for accommodating charged carriers, which can significantly enhance performance. However, ascribing intricate porosity functionalities a single COF structure, while maintaining long‐term stability, is challenging. Efforts overcome these hurdles embrace strategies implementation reversible linkages flexibility, stimuli‐responsive functionalities, incorporating groups promote heterostructures. This review focuses on recent progress EES devices, batteries supercapacitors, through meticulous exploration latest aimed at optimizing advanced electrodes future technologies.

Language: Английский

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From Synthesis of Amino Acids and Peptides to Enzymatic Catalysis: A Bottom‐Up Approach in Mechanochemistry

ChemSusChem, Journal Year: 2018, Volume and Issue: 11(9), P. 1410 - 1420

Published: Feb. 13, 2018

Abstract Recently, chemical reactions induced or facilitated by mechanical energy have gained recognition in diverse areas of synthesis. In particular, mechanosyntheses amino acids and short peptides, along with their applications catalysis, revealed the high degree stability peptide bonds environments harsh stress. These observations quickly led to recent interest developing mechanochemical enzymatic reactions. Experimentally, manual grinding, ball‐milling techniques, twin‐screw extrusion technology proven valuable convey forces into a practices enabled establishment more sustainable alternatives for synthesis reducing use organic solvents waste production, thereby having direct impact on E‐factor process. this Minireview, series events that allowed development are described from bottom‐up perspective.

Language: Английский

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