Chemical Reviews,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 7, 2025
Constructing
chemical
bonds
under
green
sustainable
conditions
has
drawn
attention
from
environmental
and
economic
perspectives.
The
dissociation
of
(hetero)aryl-halide
is
a
crucial
step
most
arylations
affording
(hetero)arene
derivatives.
Herein,
we
summarize
the
(hetero)aryl
halides
activation
enabling
direct
(hetero)arylation
trapping
reagents
construction
highly
functionalized
(hetero)arenes
benign
conditions.
strategies
for
aryl
iodides
are
classified
into
(a)
hypervalent
iodoarene
followed
by
functionalization
thermal/photochemical
conditions,
(b)
aryl-I
bond
in
presence
bases
with/without
organic
catalysts
promoters,
(c)
photoinduced
presence/absence
organophotocatalysts,
(d)
electrochemical
direct/indirect
electrolysis
mediated
organocatalysts
mediators
acting
as
electron
shuttles,
(e)
electrophotochemical
redox-active
organocatalysts.
These
modes
result
exhibiting
diverse
reactivity
formal
cations/radicals/anions
aryne
precursors.
coupling
these
reactive
intermediates
with
leads
to
facile
selective
formation
C-C
C-heteroatom
bonds.
ecofriendly,
inexpensive,
functional
group-tolerant
offer
alternatives
transition
metal-based
catalysis.
Chemical Reviews,
Journal Year:
2021,
Volume and Issue:
122(2), P. 2487 - 2649
Published: Nov. 9, 2021
Redox
processes
are
at
the
heart
of
synthetic
methods
that
rely
on
either
electrochemistry
or
photoredox
catalysis,
but
how
do
and
catalysis
compare?
Both
approaches
provide
access
to
high
energy
intermediates
(e.g.,
radicals)
enable
bond
formations
not
constrained
by
rules
ionic
2
electron
(e)
mechanisms.
Instead,
they
1e
mechanisms
capable
bypassing
electronic
steric
limitations
protecting
group
requirements,
thus
enabling
chemists
disconnect
molecules
in
new
different
ways.
However,
while
providing
similar
intermediates,
differ
several
physical
chemistry
principles.
Understanding
those
differences
can
be
key
designing
transformations
forging
disconnections.
This
review
aims
highlight
these
similarities
between
comparing
their
underlying
principles
describing
impact
electrochemical
photochemical
methods.
Chemical Reviews,
Journal Year:
2021,
Volume and Issue:
121(10), P. 5741 - 5829
Published: April 9, 2021
Aryl
diazonium
salts
are
versatile
building
blocks
in
organic
synthesis.
In
light
of
the
ever-increasing
importance
aryl
spanning
most
disciplines
chemical
sciences,
we
review
recent
development
chemistry
over
past
seven
years
(2013-2020).
Special
emphasis
is
put
on
various
new
transformations
involving
generation
radical
intermediates
via
thermal,
photochemical,
and
electrochemical
means.
Recent
advances
transition
metal-catalyzed
reactions
using
also
reviewed.
Together,
these
newly
developed
significantly
expand
synthetic
chemist's
repertoire
aromatic
carbon-carbon
carbon-heteroatom
bond
forming
methods
precursors,
providing
powerful
tools
for
synthesis
modification
complex
molecular
scaffolds.
Chemical Society Reviews,
Journal Year:
2022,
Volume and Issue:
51(6), P. 2313 - 2382
Published: Jan. 1, 2022
Visible-light
photoredox
catalysis
has
been
regarded
as
an
extremely
powerful
tool
in
organic
chemistry,
bringing
the
spotlight
back
to
radical
processes.
The
versatility
of
photocatalyzed
reactions
already
demonstrated
be
effective
providing
alternative
routes
for
cross-coupling
well
multicomponent
reactions.
photocatalyst
allows
generation
high-energy
intermediates
through
light
irradiation
rather
than
using
highly
reactive
reagents
or
harsh
reaction
conditions.
In
a
similar
vein,
electrochemistry
experienced
fruitful
renaissance
generating
without
need
any
catalyst.
Such
milder
approaches
pose
basis
toward
higher
selectivity
and
broader
applicability.
electrochemical
reactions,
species
acts
starter
cascade
events.
This
diverse
reactivity
use
is
usually
not
covered
by
classical
methods.
Owing
availability
cheaper
more
standardized
photo-
reactors,
easily
scalable
flow-setups,
it
surprising
that
these
two
fields
have
become
areas
increased
research
interest.
Keeping
view,
this
review
aimed
at
overview
synthetic
design
MCRs
involving
and/or
activation
crucial
step
with
particular
focus
on
choice
difunctionalized
reagent.
ACS Sustainable Chemistry & Engineering,
Journal Year:
2019,
Volume and Issue:
7(16), P. 14153 - 14160
Published: July 15, 2019
A
efficient
and
sustainable
approach
for
the
synthesis
of
3-alkylquinoxalin-2(1H)-ones
has
been
developed
through
visible-light-mediated
decarboxylative
alkylation
quinoxalin-2(1H)-ones
with
phenyliodine(III)
dicarboxylates.
This
photocatalytic
reaction
could
be
conducted
at
ambient
temperature
by
employing
eco-friendly
PEG-200
as
medium.
Various
were
easily
obtained
present
ruthenium(II)
catalytic
system,
which
successfully
recycled
five
times
without
significant
decrease
its
efficiency.
Green Chemistry,
Journal Year:
2019,
Volume and Issue:
22(2), P. 433 - 438
Published: Nov. 26, 2019
The
first
example
of
selective
oxidation
sulfides
to
sulfones
and
sulfoxides
using
molecular
oxygen
under
clean
conditions
was
established.
desired
products
could
be
easily
collected
through
recrystallization
in
large-scale
preparation.
ChemSusChem,
Journal Year:
2021,
Volume and Issue:
14(22), P. 4878 - 4902
Published: Sept. 3, 2021
Sulfones
play
a
pivotal
role
in
modern
organic
chemistry.
They
are
highly
versatile
building
blocks
and
find
various
applications
as
drugs,
agrochemicals,
or
functional
materials.
Therefore,
sustainable
access
to
this
class
of
molecules
is
great
interest.
Herein,
the
goal
was
provide
summary
on
recent
developments
field
sulfone
synthesis.
Advances
existing
limitations
traditional
approaches
towards
sulfones
were
reviewed
selected
examples.
Furthermore,
novel
emerging
technologies
for
more
synthesis
future
directions
discussed.
Green Chemistry,
Journal Year:
2020,
Volume and Issue:
22(6), P. 1906 - 1910
Published: Jan. 1, 2020
A
metal-free
route
to
alkynyl
sulfones
under
photoinduced
conditions
is
accomplished,
starting
from
4-alkyl
Hantzsch
esters,
sulfur
dioxide,
and
bromides
visible
light
irradiation
at
room
temperature.
