Access to Carbonyl Azides via Iodine(III)-Mediated Cross-Coupling DOI Creative Commons
Qing Yan,

Lanlan Lv,

Li Xu

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: 26(43), P. 9215 - 9220

Published: Oct. 17, 2024

Herein, we present a prominent metal-free C-N cross-coupling platform that enables access to carbamoyl- and ketoazides from isocyanides or silyl enol ethers trimethylsilyl azide (TMSN

Language: Английский

Unravelling a bench-stable zinc-amide compound as highly active multitasking catalyst for radical-mediated selective alk(en)ylation of unactivated carbocycles under mild conditions DOI Creative Commons

Sangita Sahoo,

Subarna Manna,

Arnab Rit

et al.

Chemical Science, Journal Year: 2024, Volume and Issue: 15(14), P. 5238 - 5247

Published: Jan. 1, 2024

The direct functionalization of unactivated organic moieties

Language: Английский

Citations

6
N‐Directed defluorinative γ‐C(sp3)−H allylation of sulfamate esters for synthesis of gem‐difluoroalkenes via photoredox catalysis DOI
Jiawen Yang, Meng Li,

Guang‐Qiang Tan

et al.

European Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 27(17)

Published: March 29, 2024

Abstract gem ‐Difluoroalkenes are unique structural motifs with important applications ranging from drugs to materials. Herein, we report a novel radical‐mediated defluorinative allylation of sulfamate esters through distal C(sp 3 )−H functionalization under photoredox conditions. The reaction could readily incorporate various ‐difluoroalkene into previously unfunctionalized sp carbon centers. transformation allows directly dual activation N−H and bonds via photocatalytic redox‐neutral process, as well using water environmentally friendly co‐solvent. provide general operationally simple method access compounds high diversity.

Language: Английский

Citations

2
Nitrogen-directed unactivated γ-C(sp3)–H functionalization of amides toward 7-membered lactones via photoredox catalysis DOI

Guang‐Qiang Tan,

Ke-Dong Xu,

Haitao Qin

et al.

Organic Chemistry Frontiers, Journal Year: 2024, Volume and Issue: 11(13), P. 3724 - 3728

Published: Jan. 1, 2024

A concise radical-mediated [5 + 2] annulation reaction is developed for the synthesis of alkene/alkyne-containing 7-membered lactones.

Language: Английский

Citations

2
N-Directed, Radical Relay Enantioconvergent Sulfinylation of Distal C(sp3)–H Bonds via Cobalt Catalysis DOI

Ke-Dong Xu,

Xing-Yu Gong,

Meng Li

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 17, 2024

Cobalt-catalyzed enantioconvergent cross-coupling of C(sp

Language: Английский

Citations

0
Ultrasound-Assisted Remote Benzylic C(sp3)–H Alkylation of N-Fluoroamides with Enol Silanes DOI
Boyi Wang, Tianyu Lu, Ziyu Wang

et al.

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 89(22), P. 16473 - 16484

Published: Nov. 7, 2024

We have developed an ultrasound-assisted remote benzylic C(sp3)–H alkylation of N-fluorobenzamides with enol silanes; a series β-aryl substituted propiophenones was generated in good to high yields. This reaction represents formal C(sp3)–C(sp3) coupling and features simplicity, efficiency, wide substrate scope multiple-step sequential process, which involves N–F homolysis, 1,5-hydrogen atom transfer, radical addition, oxidation by copper(II) salt, removal the trimethylsilyl group. Also, DFT theoretical calculations Marcus theory were employed consolidate proposed mechanism.

Language: Английский

Citations

0
Access to Carbonyl Azides via Iodine(III)-Mediated Cross-Coupling DOI Creative Commons
Qing Yan,

Lanlan Lv,

Li Xu

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: 26(43), P. 9215 - 9220

Published: Oct. 17, 2024

Herein, we present a prominent metal-free C-N cross-coupling platform that enables access to carbamoyl- and ketoazides from isocyanides or silyl enol ethers trimethylsilyl azide (TMSN

Language: Английский

Citations

0