SAGE Open Medicine,
Journal Year:
2024,
Volume and Issue:
12
Published: Jan. 1, 2024
Ensuring
the
proper
management
of
neuropathic
pain
is
a
contemporary
challenge
for
professionals
who
care
patients
with
this
type
pain.
The
estimated
prevalence
in
Europe
7%–8%.
objective
study
was
to
perform
non-systematic
review
on
diagnosis,
screening,
and
quantification
For
purpose,
search
conducted
PubMed/Medline,
ScienceDirect,
OVID,
SciELO
databases
available
evidence.
findings
highlight
common
occurrence
chronic
clinical
practice.
However,
diagnosing
managing
pose
challenges
due
its
complexity
individualized
nature
cases.
Precise
diagnosis
crucial
effective
management,
involving
therapeutic
approaches
that
go
beyond
traditional
treatments.
It
noteworthy
until
recent
times,
general
questionnaires
were
utilized
assess
pain,
lacking
ability
distinguish
it
from
nociceptive
or
evaluate
broader
impact
well-being.
Biomarker
panels
hold
promise
identifying
treatable
causes
evaluating
treatment
effectiveness.
In
conclusion,
describes
diagnostic
methods
tools
screening
quantifying
European Journal of Pain,
Journal Year:
2023,
Volume and Issue:
28(1), P. 105 - 119
Published: Aug. 11, 2023
Abstract
Background
Neuropathic
pain
is
common
and
difficult
to
treat.
The
sodium
channel
blocker
lacosamide
efficacious
in
animal
models
of
pain,
but
its
effect
on
neuropathic
humans
inconclusive.
Methods
In
a
multicentre,
randomized,
double‐blinded
placebo‐controlled
phenotype
stratified
trial,
we
examined
if
produced
better
relief
patients
with
the
irritable
nociceptor
compared
those
without.
primary
outcome
was
change
daily
average
from
baseline
last
week
12
weeks
treatment.
Secondary
tertiary
outcomes
included
relief,
patient
global
impression
presence
30%
50%
reduction.
Results
study
prematurely
closed
93
63
randomized
or
placebo
2:1
ratio,
which
49
fulfilled
per
protocol
criteria
used
for
objective.
We
did
not
find
phenotype,
95%
CI
objective
0.41
(−1.2
2.0).
For
all
had
no
outcome,
significantly
more
were
responders
than
during
placebo,
an
NNT
4.0
(95%
2.3–16.1)
5.0
2.8–24.5)
reduction
respectively.
identify
any
predictors
response.
Lacosamide
generally
well
tolerated.
Conclusion
could
confirm
that
type,
closed,
so
cannot
exclude
small
difference.
Significance
Treatment
often
trial
error
process.
Little
known
about
benefit
kind
medication.
shows
variable
pain.
Pain
sensory
as
defined
by
quantitative
testing,
predict
response
treatment
lacosamide.
European Journal of Pain,
Journal Year:
2025,
Volume and Issue:
29(2)
Published: Jan. 21, 2025
ABSTRACT
Background
and
Objective
Non‐invasive
neuromodulation
techniques
(NIN),
such
as
transcranial
Direct
Current
Stimulation
(tDCS)
repetitive
Transcranial
Magnetic
(rTMS),
have
been
extensively
researched
for
their
potential
to
alleviate
pain
by
reversing
neuroplastic
changes
associated
with
neuropathic
(NP),
a
prevalent
complex
condition.
However,
treating
NP
remains
challenging
due
the
numerous
variables
involved,
different
techniques,
dosages
aetiologies.
It
is
necessary
provide
insights
clinicians
public
healthcare
managers
support
clinical
decision‐making.
This
umbrella
review
aims
consolidate
existing
evidence
on
effectiveness
of
various
NIN
in
managing
chronic
NP.
Databases
Data
Treatment
A
systematic
search
was
conducted
PubMed/MEDLINE
database,
including
meta‐analyses
controlled
trials
comparing
sham
interventions
treatment.
The
quality
included
studies
assessed
using
AMSTAR‐2
tool
GRADE
system,
effect
sizes
adjusted
standard
mean
difference
(SMD).
Results
22
comprising
8151
participants
from
214
trials.
most
investigated
were
tDCS
rTMS,
primary
targets
being
motor
cortex
dorsolateral
prefrontal
cortex.
findings
suggest
that
excitatory
protocols,
particularly
high‐frequency
rTMS
anodal
tDCS,
are
effective
reducing
intensity
individuals
overall
rated
low,
primarily
heterogeneity
among
small
sample
sizes.
Conclusion
show
promise
NP,
benefits
reduction.
further
high‐quality
research
needed
establish
optimal
protocols
long‐term
effects.
Significance
Statement
paper
consolidates
regarding
non‐invasive
treatment
pain,
differentiating
based
aetiology
provides
easy
access
this
critical
information.
also
highlights
key
aspects
require
field
pain.
