Pain and Therapy, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 28, 2024
Language: Английский
Journal of Neuroinflammation, Journal Year: 2025, Volume and Issue: 22(1)
Published: Feb. 7, 2025
Mitochondrial dysfunction is a pivotal instigator of neuroinflammation, with mitochondrial DNA (mtDNA) leakage as critical intermediary. This review delineates the intricate pathways leading to mtDNA release, which include membrane permeabilization, vesicular trafficking, disruption homeostatic regulation, and abnormalities in dynamics. The escaped activates cytosolic sensors, especially cyclic gmp-amp synthase (cGAS) signalling inflammasome, initiating neuroinflammatory cascades via pathways, exacerbating spectrum neurological pathologies. therapeutic promise targeting discussed detail, underscoring necessity for multifaceted strategy that encompasses preservation homeostasis, prevention leakage, reestablishment dynamics, inhibition activation sensors. Advancing our understanding complex interplay between neuroinflammation imperative developing precision interventions disorders.
Language: Английский
Citations
3
British Journal of Anaesthesia, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Chronic neuropathic pain generally has a poor response to treatment with conventional drugs. Sympathectomy can alleviate in some patients, suggesting that abnormal sympathetic-somatosensory signaling interactions might underlie forms of pain. The molecular mechanisms underlying remain obscure. Lumbar sympathectomy was performed spared nerve injury (SNI) mice or rats, and the up-down method used measure mechanical paw withdrawal threshold. Dorsal root ganglia (DRG) injection perfusion were deliver virus Methylated RNA immunoprecipitation sequencing, RNA-sequencing, immunoelectron microscopy identify neurotransmitters. We found sprouting tyrosine hydroxylase-positive sympathetic fibres DRG mediated maintenance allodynia after SNI (day 28, P<0.001). further significantly increased N6-methyladenosine level CXCL16 messenger P<0.001), which attributable reduced demethylase fat mass obesity-associated protein (P=0.002) interaction YTHDF1 (P=0.013) ganglion. Enhanced expression lead increases release into act synergistically norepinephrine from terminals enhance neuronal excitability. Norepinephrine co-released contribute rodent model.
Language: Английский
Citations
1
Journal of Neuroimmune Pharmacology, Journal Year: 2025, Volume and Issue: 20(1)
Published: Feb. 12, 2025
Language: Английский
Citations
1
Trends in Molecular Medicine, Journal Year: 2024, Volume and Issue: 30(7), P. 642 - 659
Published: April 8, 2024
Language: Английский
Citations
6
Molecules, Journal Year: 2023, Volume and Issue: 28(15), P. 5766 - 5766
Published: July 30, 2023
Neuropathic pain is a debilitating condition that affects millions of people worldwide. Numerous studies indicate this type chronic with complex mechanism tends to worsen over time, leading significant deterioration in patients’ quality life and issues like depression, disability, disturbed sleep. Presently used analgesics are not effective enough neuropathy treatment may cause many side effects due the high doses needed. In recent years, researchers have pointed important role chemokines only development maintenance but also effectiveness analgesic drugs. Currently, approximately 50 known act through 20 different seven-transmembrane G-protein-coupled receptors located on surface neuronal, glial, immune cells. Data from years clearly more than initially thought (CCL1/2/3/5/7/8/9/11, CXCL3/9/10/12/13/14/17; XCL1, CX3CL1) pronociceptive properties; therefore, blocking their action by using neutralizing antibodies, inhibiting synthesis, or brings neuropathic relief. Several them (CCL1/2/3/7/9/XCL1) been shown be able reduce opioid drug neuropathy, antibodies against can restore morphine and/or buprenorphine analgesia. The latest research provides irrefutable evidence chemokine promising targets for pharmacotherapy; receptor antagonists relieve etiologies, most enhance analgesia, example, blockade CCR1 (J113863), CCR2 (RS504393), CCR3 (SB328437), CCR4 (C021), CCR5 (maraviroc/AZD5672/TAK-220), CXCR2 (NVPCXCR220/SB225002), CXCR3 (NBI-74330/AMG487), CXCR4 (AMD3100/AMD3465), XCR1 (vMIP-II). Recent has multitarget receptors, such as CCR2/5 (cenicriviroc), CXCR1/2 (reparixin), CCR2/CCR5/CCR8 (RAP-103), very painkillers. A multidirectional strategy based modulation neuronal–glial–immune interactions changing activity family significantly improve patients suffering pain. However, members still underestimated pharmacological treatment. article, we review literature provide new insights into
Language: Английский
Citations
15
British Journal of Anaesthesia, Journal Year: 2023, Volume and Issue: 132(2), P. 372 - 382
Published: Dec. 15, 2023
Language: Английский
Citations
13
Neurochemical Research, Journal Year: 2024, Volume and Issue: 49(4), P. 872 - 886
Published: Jan. 28, 2024
Language: Английский
Citations
5
Healthcare, Journal Year: 2024, Volume and Issue: 12(5), P. 555 - 555
Published: Feb. 28, 2024
Neuropathic pain is caused by a lesion or disease of the somatosensory system and one most incapacitating types, representing significant non-met medical need. Due to increase in research field since innovative therapeutic strategies are required, namely intractable neuropathic pain, neurostimulation has been used. Within this approach, transcranial magnetic stimulation (TMS) that uses transient produce electrical currents over cortex emerges as popular method literature. Since an area expansion due putative role TMS, we performed bibliometric analysis Scopus with primary objective identifying scientific production related use TMS manage pain. The had no restrictions, focused on characteristics literature retrieved, collaboration main topics from inception 6 July 2023. A total 474 articles were collected. biggest co-occurrence between terms "neuropathic pain" "transcranial stimulation" was obtained. journal "Clinical Neurophysiology" leads Top 5 productive sources. United States country, 50% US documents being "review articles", followed France, 56% French "original articles". Lefaucheur, JP Saitoh, Y two influential authors. frequent type document article". Most studies (34%) identified traumatic although large proportion (38%) did not report type. This study allows us provide general overview application for useful establishing future directions field.
Language: Английский
Citations
5
Neuroscience Bulletin, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 20, 2025
Language: Английский
Citations
0
Frontiers in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 13
Published: Feb. 21, 2025
Neuropathic pain (NPP) is caused by damage to the somatosensory nervous system. Its prominent symptoms are spontaneous pain, hyperalgesia and abnormal pain. This long-lasting unbearable, seriously affecting patient's quality of life. At present, clinical treatment effect painkillers relieve NPP still not ideal, nor can it repair damaged nerves achieve long-term results. In recent years, application cell therapy strategies in field has yielded encouraging results, including preclinical studies trials. Mesenchymal stem cells (MSCs) pluripotent progenitor derived from mesogenesis. They have ability self-renew differentiate into multiple types been widely studied applied neuroregenerative medicine. MSCs play an important mechanism functional role promoting injured nerve regeneration relief regulating processes target cells, immunoregulation, anti-inflammatory properties, axon re-myelination, angiogenesis, secreting neurotrophic factors. Moreover, also release exosomes, which may be part their analgesic effects. Exosomes MSC properties mother therapeutic potential for treating proliferation, inflammatory responses, reducing death, angiogenesis. Therefore, this article, we discussed current explored NPP. We analyzed problems challenges trials
Language: Английский
Citations
0