Pt/Zn-TCPP Nanozyme-Based Flexible Immunoassay for Dual-Mode Pressure–Temperature Monitoring of Low-Abundance Proteins

Analytical Chemistry, Journal Year: 2024, Volume and Issue: 96(21), P. 8740 - 8746

Published: May 9, 2024

Pressure and temperature, as common physical parameters, are important for monitoring human health. In contrast, single-mode is prone to causing experimental errors. Herein, we innovatively designed a dual-mode flexible sensing platform based on platinum/zinc-meso-tetrakis(4-carboxyphenyl)porphyrin (Pt/Zn-TCPP) nanozyme the quantitative of carcinoembryonic antigen (CEA) in biological fluids with pressure temperature readouts. The Pt/Zn-TCPP catalytic photothermal efficiencies was synthesized by means integrating photosensitizers into porous materials. system after antigen–antibody reaction recognized using skin-like sensor digital multimeter readout, whereas acquired via photoheat conversion under 808 nm near-infrared (NIR) irradiation portable NIR imaging camera smartphone. Meanwhile, carried out homemade three-dimensional (3D)-printed device. Results revealed that developed immunosensing could exhibit good responses within dynamic range 0.5–100 ng mL–1 CEA detection limits 0.24 0.13 mL–1, respectively. addition, were sensed simultaneously without crosstalk interference. Importantly, can effectively avoid false alarms during measurement, thus providing great potential simple low-cost development point-of-care testing.

Language: Английский

---

Multi‐Mode/Signal Biosensors: Electrochemical Integrated Sensing Techniques

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: May 14, 2024

Abstract Electrochemical (EC) analysis has emerged as a high‐sensitivity, reliable, cost‐effective, and rapidly evolving technique that garnered significant attention across diverse domains. Furthermore, EC‐based techniques hold great potential for miniaturization integration. The integration of EC with mode/signal (such light, magnetic, thermal signals, etc.) provides unique opportunities biosensors to acquire more information through single sensing platform. By coupling multiple signals or processing them logically, the detection accuracy can be further improved, probability false positives negatives minimized. In this review, thorough multi‐ sensors in field is conducted, along their various (e.g., fluorescence, photothermal, colorimetry, microfluidic, etc.). aim delve into latest advances, applications, well challenges multi‐mode/signal biosensors, where utilization modalities helps enhance accuracy, sensitivity, selectivity. This review new insight synergistic effects integrating other techniques, aiming shed light on near‐future developments EC‐integrated biosensors.

Language: Английский

---

Recent advances in flexible sensors: From sensing materials to detection modes

TrAC Trends in Analytical Chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 118027 - 118027

Published: Oct. 1, 2024

Language: Английский

---

Target-induced oxygen vacancy on the etching WO3 photoanode for in-situ amplified photoelectrochemical immunoassay

Biosensors and Bioelectronics, Journal Year: 2025, Volume and Issue: unknown, P. 117405 - 117405

Published: March 1, 2025

Language: Английский

---

Electrochemical methods for the detection of heavy metal ions: From sensors to biosensors

Microchemical Journal, Journal Year: 2024, Volume and Issue: 207, P. 112086 - 112086

Published: Nov. 13, 2024

Language: Английский

---

Cutting-edge progress in carbon nanomaterial-functionalized silver nanoparticles for enhanced optical and electrochemical sensing applications

TrAC Trends in Analytical Chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 117995 - 117995

Published: Oct. 1, 2024

Language: Английский

---

Recent advancements in nanobiosensors for diagnosis of ovarian cancer: Analytical approaches

TrAC Trends in Analytical Chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 118119 - 118119

Published: Dec. 1, 2024

Language: Английский

---

Recent progress in molecular diagnostics: The synergy of rolling circle amplification and CRISPR/Cas systems (2018–2024) – A concise review

TrAC Trends in Analytical Chemistry, Journal Year: 2024, Volume and Issue: 180, P. 117902 - 117902

Published: Aug. 8, 2024

Language: Английский

---

Advances in Biosensor Technologies for Infectious Diseases Detection

TrAC Trends in Analytical Chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 117979 - 117979

Published: Sept. 1, 2024

Language: Английский

---

Rapid Recognition and Monitoring of Multiple Core Biomarkers with Point-of-Care Importance through Combinatorial DNA Logic Operation

Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 21, 2025

The early diagnosis of a disease relies on the reliable identification and quantitation multiple core biomarkers in real-time point-of-care (POC) testing. To date, most multiplex photoelectrochemical (PEC) assays are inaccessible to home healthcare due cumbersome steps, long testing time, limited detection efficiency. rapid fast-response generation independent photocurrent for targets is still great challenge. Herein, combinatorial DNA logic operation-guided PEC sensor constructed facilely distinguish simultaneously monitor two that essential identifying asymptomatic Alzheimer patients predicting progression disease. aptamers amyloid-β oligomers (AβO) Tau441 protein simply integrated at high-performance In-TBAPy photocathode. In presence AβO protein, aptamer-target affinity complexes formed subsequently detached from electrode surface, resulting an increase photocurrent. Through programming concatenated molecular circuits, 2-target input OR gate not only simplifies manufacturing process but also realizes intelligent multiple-target recognition. As conceptual prototype development more sophisticated complicated devices, proposed system may open new horizon POC analysis.

Language: Английский

---