Biosensors,
Journal Year:
2022,
Volume and Issue:
12(7), P. 503 - 503
Published: July 9, 2022
Food
allergy
has
been
indicated
as
the
most
frequent
adverse
reaction
to
food
ingredients
over
past
few
years.
Since
only
way
avoid
occurrence
of
allergic
phenomena
is
eliminate
allergenic
foods,
it
essential
have
complete
and
accurate
information
on
components
foodstuff.
In
this
framework,
mandatory
crucial
provide
fast,
cost-effective,
affordable,
reliable
analysis
methods
for
screening
specific
allergen
content
in
products.
This
review
reports
research
advancements
concerning
detection,
involving
electrochemical
biosensors.
It
focuses
sensing
strategies
evidencing
different
types
recognition
elements
such
antibodies,
nucleic
acids,
cells,
among
others,
nanomaterial
role,
several
techniques
involved
last,
but
not
least,
ad
hoc
electrodic
surface
modification
approaches.
Moreover,
a
selection
recent
sensors
detection
are
reported
critically
analyzed
terms
sensors’
analytical
performances.
Finally,
advantages,
limitations,
potentialities
practical
applications
biosensors
allergens
discussed.
Microchimica Acta,
Journal Year:
2025,
Volume and Issue:
192(4)
Published: March 5, 2025
The
review
article
provides
a
short
introduction
to
exosomes
with
the
focus
use
as
disease
markers
itself
(i.e.
their
concentration
or
presence
of
some
specific
receptors)
source
biomarkers
such
proteins
and
metabolites.
In
detail,
we
are
discussing
various
methods
exosome
isolation
main
paper
is
on
affinity
capture
exosomes,
since
them
can
be
applied
sub-populations
produced
by
organs.
comprehensive
overview
magnetic
(bio)affinity
detection
exosomal
cargo
using
different
ligands
antibodies,
DNA
aptamers,
peptides,
glycan-based
recognition,
transferrin-based
approaches,
based
recognition
phospholipids
other
approaches
including
electrostatic
interactions.
in
detail
key
analytical
clinical
parameters
form
an
extensive
table
summarising
outcomes
published
last
two
years
(2023-2024).
Finally,
also
conclusions
sections
pros
cons
for
and/or
determination
content.
Analytical and Bioanalytical Chemistry,
Journal Year:
2023,
Volume and Issue:
415(29-30), P. 7035 - 7045
Published: Oct. 5, 2023
Abstract
A
major
societal
challenge
is
the
development
of
necessary
tools
for
early
diagnosis
diseases
such
as
cancer
and
sepsis.
Consequently,
there
a
concerted
push
to
develop
low-cost
non-invasive
methods
analysis
with
high
sensitivity
selectivity.
notable
trend
highly
sensitive
that
are
not
only
amenable
point-of-care
(
POC
)
testing,
but
also
wearable
devices
allowing
continuous
monitoring
biomarkers.
In
this
context,
test
detection
promising
biomarker,
protein
Interleukin-6
(IL-6),
could
represent
significant
advance
in
clinical
management
cancer,
chemotherapy
response,
or
prompt
This
work
reports
capacitive
electrochemical
impedance
spectroscopy
sensing
platform
tailored
towards
treatment
human
serum.
The
specific
recognition
IL-6
was
achieved
employing
gold
surfaces
modified
an
anti-IL6
nanobody
(anti-IL-6
VHH)
aptamer.
first
system,
anti-IL-6
VHH
covalently
attached
surface
using
binary
self-assembled-monolayer
(SAM)
6-mercapto-1-hexanol
(MCH)
11-mercaptoundecanoic
acid.
second
aptamer
chemisorbed
onto
mixed
SAM
layer
MCH.
analytical
performance
each
label-free
sensor
evaluated
buffer
10%
serum
samples
then
compared.
results
were
generated
low-cost,
thin
film
eight-channel
array
produced
on
flexible
substrate
providing
useful
information
future
design
biomarker
platforms.
Microchemical Journal,
Journal Year:
2023,
Volume and Issue:
190, P. 108594 - 108594
Published: March 4, 2023
Aflatoxin,
a
member
of
mycotoxins
produced
by
molds,
is
well
known
for
its
serious
health
implications
humans
and
animals
alike.
The
global
issue
aflatoxins
entering
the
food
chain
poses
public
risk
that
should
not
be
underestimated.
It
finds
way
into
through
variety
routes,
including
contaminated
animal
feed
milk.
Given
hazardous
nature
aflatoxin,
call
rapid
reliable
detection
methods
toxin
in
milk
more
important
than
ever.
With
advent
nanotechnology,
newly
emerging
electrochemical
biosensors
can
present
an
answer
to
this
call.
In
review,
immunosensors
aptasensors,
two
most
commonly
developed
detect
aflatoxin
milk,
are
summarized.
Expanding
complementing
existing
reviews,
article
provides
compelling
overview
over
latest
developments
field
discusses
future
directions
as
challenges
remain
addressed.
ACS Sensors,
Journal Year:
2023,
Volume and Issue:
8(9), P. 3276 - 3293
Published: Aug. 3, 2023
Electrochemical
affinity
biosensors
are
evolving
at
breakneck
speed,
strengthening
and
colonizing
more
niches
drawing
unimaginable
roadmaps
that
increasingly
make
them
protagonists
of
our
daily
lives.
They
achieve
this
by
combining
their
intrinsic
attributes
with
those
acquired
leveraging
the
significant
advances
occurred
in
(nano)materials
technology,
bio(nano)materials
nature-inspired
receptors,
gene
editing
amplification
technologies,
signal
detection
processing
techniques.
The
aim
Perspective
is
to
provide,
support
recent
representative
illustrative
literature,
an
updated
critical
view
repertoire
opportunities,
innovations,
applications
offered
electrochemical
fueled
key
alliances
indicated.
In
addition,
imminent
challenges
these
biodevices
must
face
new
directions
which
they
envisioned
as
players
discussed.
IEEE Sensors Journal,
Journal Year:
2024,
Volume and Issue:
24(5), P. 5746 - 5758
Published: Jan. 9, 2024
Cortisol,
also
known
as
the
"stress
hormone,"
is
secreted
under
control
of
hypothalamic-pituitary-adrenocortical
(HPA)
axis
in
response
to
psychobiological
stress.
Real-time
and
continuous
monitoring
cortisol
levels
throughout
day
can
provide
information
necessary
identify
any
abnormalities
cortisol's
circadian
rhythm
that
may
disrupt
several
processes
involved
body.
This
review
presents
a
systematic
search
literature
on
electrochemical
sensing
techniques
allow
real-time
measurement
human
biofluids.
Several
structural
performance-related
parameters
sensors
are
being
discussed,
including
sensor
stack
layers,
limit
detection
(LoD),
dynamic
range,
sensitivity,
selectivity,
reusability,
redox
probe
usage,
technique
used.
The
here
primarily
categorized
based
type
bioreceptors
used:
antibodies,
molecularly
imprinted
polymers
(MIPs),
aptamers.
According
this
review,
aptasensors
MIP-based
present,
general,
superior
stability
sensitivity
over
immunosensors.
They
promise
reversible
binding,
albeit
limited
research
exists
deploying
such
bioreceptors.
Additionally,
notable
advancements
field
their
impact
development
point-of-care
(PoC)
wearable
devices
discussed.
Microsystems & Nanoengineering,
Journal Year:
2024,
Volume and Issue:
10(1)
Published: July 17, 2024
Abstract
This
work
presents
the
development
and
design
of
aptasensor
employing
porous
silicon
(PSi)
Fabry‒Pérot
thin
films
that
are
suitable
for
use
as
optical
transducers
detection
lactoferrin
(LF),
which
is
a
protein
biomarker
secreted
at
elevated
levels
during
gastrointestinal
(GI)
inflammatory
disorders
such
bowel
disease
chronic
pancreatitis.
To
overcome
primary
limitation
associated
with
PSi
biosensors—namely,
their
relatively
poor
sensitivity
due
to
issues
related
complex
mass
transfer
phenomena
reaction
kinetics—we
employed
two
strategic
approaches:
First,
we
sought
optimize
nanostructure
respect
factors
including
layer
thickness,
pore
diameter,
capture
probe
density.
Second,
leveraged
convection
properties
by
integrating
resulting
biosensor
into
3D-printed
microfluidic
system
also
had
one
different
micromixer
architectures
(i.e.,
staggered
herringbone
micromixers
or
microimpellers)
embedded.
We
demonstrated
tailoring
significantly
improved
its
performance,
achieving
limit
(LOD)
50
nM—which
>1
order
magnitude
lower
than
achieved
using
previously-developed
biosensors
this
type.
Moreover,
integration
systems
incorporated
passive
active
further
enhanced
aptasensor’s
sensitivity,
an
additional
reduction
in
LOD
yet
another
magnitude.
These
advancements
demonstrate
potential
combining
PSi-based
technology
create
sensitive
label-free
biosensing
platforms
GI
biomarkers.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(2), P. 1309 - 1309
Published: Jan. 21, 2024
Aerogels
are
unique
solid-state
materials
composed
of
interconnected
3D
solid
networks
and
a
large
number
air-filled
pores.
This
structure
leads
to
extended
structural
characteristics
as
well
physicochemical
properties
the
nanoscale
building
blocks
macroscale,
integrated
typical
features
aerogels,
such
high
porosity,
surface
area,
low
density,
with
specific
various
constituents.
Due
their
combination
excellent
properties,
aerogels
attract
much
interest
in
applications,
ranging
from
medicine
construction.
In
recent
decades,
potential
was
exploited
many
aerogels’
materials,
either
organic,
inorganic
or
hybrid.
Considerable
research
efforts
years
have
been
devoted
development
aerogel-based
biosensors
encouraging
accomplishments
achieved.
this
work,
(2018–2023)
ground-breaking
advances
preparation,
classification,
sensing
applications
presented.
Different
types
which
play
fundamental
role
being
explored
collected
manuscript.
Moreover,
current
challenges
some
perspectives
for
high-performance
summarized.
ACS Applied Bio Materials,
Journal Year:
2024,
Volume and Issue:
7(6), P. 3721 - 3730
Published: March 15, 2024
C-reactive
protein
(CRP)
is
an
acute-phase
reactant
and
sensitive
indicator
for
sepsis
other
life-threatening
pathologies,
including
systemic
inflammatory
response
syndrome.
Currently,
clinical
turn-around
times
established
CRP
detection
methods
take
between
30
min
to
hours
or
even
days
from
centralized
laboratories.
Here,
we
report
the
development
of
electrochemical
biosensor
using
redox
probe-tagged
DNA
aptamers,
functionalized
onto
inexpensive,
commercially
available
screen-printed
electrodes.
Binding-induced
conformational
switching
CRP-targeting
aptamer
induces
a
specific
selective
signal-ON
event,
which
enables
single-step
reagentless
in
as
little
1
min.
The
aptasensor
limit
spans
approximately
20–60
nM
50%
human
serum
with
dynamic
windows
spanning
1–200
1–500
(R
=
0.97/R
0.98
respectively).
sensor
stable
at
least
week
can
be
reused
numerous
times,
judged
repeated
real-time
dosing
dose–response
assays.
By
decoupling
binding
events
signal
induction
mechanism,
structure-switching
aptamer-based
sensors
provide
considerable
advantages
over
their
adsorption-based
counterparts.
Our
work
expands
on
retinue
such
reported
literature
first
instance
(SS-EABs)
reagentless,
voltammetric
detection.
We
hope
this
study
inspires
further
investigations
into
suitability
SS-EABs
diagnostics,
will
aid
translational
R&D
toward
fully
realized
devices
aimed
point-of-care
applications
broader
use
by
public.
