Pharmaceuticals and personal care products (PPCPs) in the freshwater aquatic environment

Emerging contaminants, Journal Year: 2017, Volume and Issue: 3(1), P. 1 - 16

Published: Jan. 5, 2017

Pharmaceuticals and personal care products (PPCPs) are a unique group of emerging environmental contaminants, due to their inherent ability induce physiological effects in human at low doses. An increasing number studies has confirmed the presence various PPCPs different compartments, which raises concerns about potential adverse humans wildlife. Therefore, this article reviews current state-of-knowledge on freshwater aquatic environment. The risk posed by these contaminants is evaluated light persistence, bioaccumulation toxicity criteria. Available literature sources, transport degradation environment evaluated, followed comprehensive review reported concentrations PPCP groups (water, sediment biota) five continents. Finally, future perspectives for research discussed identified gaps knowledge.

Language: Английский

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Human pharmaceuticals in the marine environment: Focus on exposure and biological effects in animal species

Environmental Toxicology and Chemistry, Journal Year: 2015, Volume and Issue: 35(4), P. 799 - 812

Published: June 25, 2015

Marine waters have been poorly investigated for the occurrence of pharmaceutical contamination. Recent data confirm that pharmaceuticals occur widely in marine and coastal environments; therefore, assessment potential risk to species needs further efforts. The present study represents first extensive review contamination environments addressing effects on biota analyzed at molecular, cellular, individual levels. Because differ from conventional pollutants, being designed interact with specific physiological pathways low doses, most recent evidence modes action alterations animal are discussed. Data spatial distributions sediments, as well bioaccumulation rates, also presented. seeks expand knowledge how quality could be efficiently monitored anticipate possible health environmental risks.

Language: Английский

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Antidepressants can induce mutation and enhance persistence toward multiple antibiotics

Proceedings of the National Academy of Sciences, Journal Year: 2023, Volume and Issue: 120(5)

Published: Jan. 23, 2023

Antibiotic resistance is an urgent threat to global health. Antidepressants are consumed in large quantities, with a similar pharmaceutical market share (4.8%) antibiotics (5%). While acknowledged as the major driver of increasing antibiotic resistance, little attention paid contribution antidepressants this process. Here, we demonstrate that at clinically relevant concentrations induce multiple antibiotics, even following short periods exposure. persistence was also enhanced. Phenotypic and genotypic analyses revealed enhanced production reactive oxygen species exposure directly associated increased resistance. An stress signature response stimulation efflux pump expression were persistence. Mathematical modeling predicted would accelerate emergence antibiotic-resistant bacteria, persister cells help maintain Overall, our findings highlight risk caused by antidepressants.

Language: Английский

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Antidepressant fluoxetine induces multiple antibiotics resistance in Escherichia coli via ROS-mediated mutagenesis

Environment International, Journal Year: 2018, Volume and Issue: 120, P. 421 - 430

Published: Aug. 18, 2018

Language: Английский

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The psychoactive pollutant fluoxetine compromises antipredator behaviour in fish

Environmental Pollution, Journal Year: 2017, Volume and Issue: 222, P. 592 - 599

Published: Jan. 5, 2017

Language: Английский

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Association of Sleep Architecture and Physiology with Depressive Disorder and Antidepressants Treatment

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(3), P. 1333 - 1333

Published: Jan. 29, 2021

Sleep problems are frequently associated with the principal diagnostic criteria for many mental disorders. Alterations in sleep of depressive patients high clinical significance because continuous raise chance relapse, recurrence, or suicide, as well need augmenting medications. Most antidepressants have been proven to influence architecture. While some classes improve sleep, others may cause impairment. The successful treatment disorder also requires an understanding effects on sleep. This article briefly reviews physiology and typical alterations architecture updates different majority including novel drugs practice summary updated scientific findings relationship between depression disturbances could be clinically beneficial choosing best medication concurrent

Language: Английский

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Pharmaceuticals and Personal Care Products as Emerging Environmental Contaminants: Prevalence, Toxicity, and Remedial Approaches

ACS Chemical Health & Safety, Journal Year: 2023, Volume and Issue: 30(6), P. 362 - 388

Published: Nov. 3, 2023

Pharmaceuticals and Personal Care Products (PPCPs) are synthetic compounds widely used as consumer items such cosmetics therapeutic drugs across the globe. The inappropriate disposal of PPCPs in environment has raised serious concerns regarding their potential adverse impacts on human animal health. Hence, present study aims to delve into environmental contamination numerous detrimental biota climate change. Mining data published relevant literature revealed that active ingredients metabolites generally invade ecosystem via multiple sources. Varying concentrations these contaminants reported surface water, groundwater, wastewater treatment plants. majority pose acute chronic toxicity living organisms. They adversely affect structure function algal community along with feeding, mating, metabolic activities, reproductive behavior invertebrates, fishes, higher vertebrates, including humans. occurrence antibiotic resistance bacterial populations a response PPCP is another health concern. In addition, targeting mitochondrial respiratory proteins cytochrome enzymes by might contribute onset physiological ailments. Studies have deciphered connection between methanogenesis, which could potentially impact Several degradation methods been for removal PPCPs. However, none them completely remove from samples. Therefore, developing more advanced eco-friendly approaches warranted better water media. further investigations required risk assessment several not yet investigated.

Language: Английский

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Levels and effects of antidepressant drugs to aquatic organisms

Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology, Journal Year: 2022, Volume and Issue: 256, P. 109322 - 109322

Published: March 7, 2022

The use of antidepressants has been increasing globally, resulting in their presence the aquatic environment, mainly by municipal wastewaters. This fact aroused concern scientific community since these biologically active compounds can affect non-target organisms that have physiological systems regulated pharmaceuticals. However, current knowledge on toxicological effects ecosystems is limited. Considering consumption pattern, quantification studies and toxicity studies, present work aimed to review available literature, published last seven years, addressing levels metabolites rivers, surface waters, tap water, wastewater treatment plants, as well, reported fish invertebrates. Overall, laboratory showed act at different biological organisation, with detrimental individual level (e.g., survival, growth, morphology, behaviour, reproduction). prolonged exposures environmentally relevant concentrations substances, a more realistic scenario, are unknown. Based short-term long-term pharmaceuticals (alone other environmental contaminants) should be studied.

Language: Английский

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1H NMR-based metabolomics of Daphnia magna responses after sub-lethal exposure to triclosan, carbamazepine and ibuprofen

Comparative Biochemistry and Physiology Part D Genomics and Proteomics, Journal Year: 2016, Volume and Issue: 19, P. 199 - 210

Published: Jan. 17, 2016

Language: Английский

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Age matters: Developmental stage of Danio rerio larvae influences photomotor response thresholds to diazinion or diphenhydramine

Aquatic Toxicology, Journal Year: 2015, Volume and Issue: 170, P. 344 - 354

Published: Sept. 26, 2015

Language: Английский

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