Combined Molecular Toxicity Mechanism of Emerging Pollutant Mixtures DOI Open Access
Xiangsheng Hong

Published: Jan. 14, 2025

Pharmaceuticals and personal care products (PPCPs) compounds are vital components of daily life modern health care. Over the past 20–25 years, a substantial amount work has been done to elucidate occurrence, bioaccumulation, fate, risks PPCPs in environment. The ubiquity most environment their potential deleterious effects on ecological human have engaged community scientists government regulators. Nontarget organisms continuously exposed multiple PPCP compounds, evidence for underestimated toxicity from such mixtures is mounting. Yet, increasing research around world still focuses overwhelmingly molecular mechanism single PPCP, scientific about combined limited date. This chapter provides an overview "state-of-the-art" literature data mechanisms PPCPs, with special emphasis mixture scenarios.

Language: Английский

Antibiotic adjuvants: synergistic tool to combat multi-drug resistant pathogens DOI Creative Commons
Vikram Kumar,

Nusrath Yasmeen,

Aishwarya Pandey

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2023, Volume and Issue: 13

Published: Dec. 20, 2023

The rise of multi-drug resistant (MDR) pathogens poses a significant challenge to the field infectious disease treatment. To overcome this problem, novel strategies are being explored enhance effectiveness antibiotics. Antibiotic adjuvants have emerged as promising approach combat MDR by acting synergistically with This review focuses on role antibiotic synergistic tool in fight against pathogens. Adjuvants refer compounds or agents that activity antibiotics, either potentiating their effects targeting mechanisms resistance. utilization offers several advantages. Firstly, they can restore existing antibiotics strains. inhibit confer resistance, making susceptible action Secondly, improving penetration into bacterial cells, increasing stability, inhibiting efflux pumps expel from cells. Various types been investigated, including pump inhibitors, resistance-modifying agents, and disrupt biofilms. These act resulting increased antibacterial overcoming resistance mechanisms. In conclusion, potential revolutionize treatment By enhancing efficacy offer strategy growing threat Further research development crucial harness full bring them closer clinical application.

Language: Английский

Citations

43
Microbial transmission in the social microbiome and host health and disease DOI Creative Commons
Amar Sarkar,

Cameron J.A. McInroy,

Siobhán Harty

et al.

Cell, Journal Year: 2024, Volume and Issue: 187(1), P. 17 - 43

Published: Jan. 1, 2024

Language: Английский

Citations

35
Antibacterial activity of nonantibiotics is orthogonal to standard antibiotics DOI Open Access
Mariana Noto Guillen, Carmen G Li, Brittany Rosener

et al.

Science, Journal Year: 2024, Volume and Issue: 384(6691), P. 93 - 100

Published: March 14, 2024

Numerous nonantibiotic drugs have potent antibacterial activity and can adversely affect the human microbiome. The mechanistic underpinning of this toxicity remains largely unknown. We investigated 200 using genetic screens with thousands barcoded

Language: Английский

Citations

34
A systematic framework for understanding the microbiome in human health and disease: from basic principles to clinical translation DOI Creative Commons

Ziqi Ma,

Tao Zuo, Norbert Frey

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Sept. 23, 2024

Language: Английский

Citations

20
Mechanism of antibacterial resistance, strategies and next-generation antimicrobials to contain antimicrobial resistance: a review DOI Creative Commons
Wubetu Yihunie, Melese Getachew, Bantayehu Addis Tegegne

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 16, 2024

Antibacterial drug resistance poses a significant challenge to modern healthcare systems, threatening our ability effectively treat bacterial infections. This review aims provide comprehensive overview of the types and mechanisms antibacterial resistance. To achieve this aim, thorough literature search was conducted identify key studies reviews on mechanisms, strategies next-generation antimicrobials contain antimicrobial In review, major with examples including target site modifications, decreased influx, increased efflux pumps, enzymatic inactivation antibacterials has been discussed. Moreover, biofilm formation, horizontal gene transfer methods also included. Furthermore, measures (interventions) taken control have discussed in detail. Overall, provides valuable insights into diverse employed by bacteria resist effects drugs, aim informing future research guiding stewardship efforts.

Language: Английский

Citations

17
The brain-gut-microbiota interplay in depression: A key to design innovative therapeutic approaches DOI Creative Commons
Angelica Varesi, Lucrezia Irene Maria Campagnoli, Salvatore Chirumbolo

et al.

Pharmacological Research, Journal Year: 2023, Volume and Issue: 192, P. 106799 - 106799

Published: May 19, 2023

Depression is the most prevalent mental disorder in world associated with huge socio-economic consequences. While depressive-related symptoms are well known, molecular mechanisms underlying disease pathophysiology and progression remain largely unknown. The gut microbiota (GM) emerging as a key regulator of central nervous system homeostasis by exerting fundamental immune metabolic functions. In turn, brain influences intestinal microbial composition through neuroendocrine signals, within so-called microbiota-brain axis. balance this bidirectional crosstalk important to ensure neurogenesis, preserve integrity blood-brain barrier avoid neuroinflammation. Conversely, dysbiosis permeability negatively affect development, behavior, cognition. Furthermore, although not fully defined yet, changes GM depressed patients reported influence pharmacokinetics common antidepressants affecting their absorption, metabolism, activity. Similarly, neuropsychiatric drugs may shape turn an impact on efficacy toxicity pharmacological intervention itself. Consequently, strategies aimed at re-establishing correct homeostatic (i.e., prebiotics, probiotics, fecal transplantation, dietary interventions) represent innovative approach improve pharmacotherapy depression. Among these, probiotics Mediterranean diet, alone or combination standard care, hold promise for clinical application. Therefore, disclosure intricate network between depression will give precious insights diagnostic therapeutic approaches towards depression, profound implications drug development practice.

Language: Английский

Citations

39
Augmented dissemination of antibiotic resistance elicited by non-antibiotic factors DOI Creative Commons
Shuyao Zhu, Bingqing Yang, Zhiqiang Wang

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2023, Volume and Issue: 262, P. 115124 - 115124

Published: June 15, 2023

The emergence and rapid spread of antibiotic resistance seriously compromise the clinical efficacy current therapies, representing a serious public health threat worldwide. Generally, drug-susceptible bacteria can acquire through genetic mutation or gene transfer, among which horizontal transfer (HGT) plays dominant role. It is widely acknowledged that sub-inhibitory concentrations antibiotics are key drivers in promoting transmission resistance. However, accumulating evidence recent years has shown addition to antibiotics, non-antibiotics also accelerate genes (ARGs). Nevertheless, roles potential mechanisms non-antibiotic factors ARGs remain largely underestimated. In this review, we depict four pathways HGT their differences, including conjugation, transformation, transduction vesiduction. We summarize accounting for enhanced underlying molecular mechanisms. Finally, discuss limitations implications studies.

Language: Английский

Citations

35
A global atlas of marine antibiotic resistance genes and their expression DOI

Nuohan Xu,

Danyan Qiu,

Zhenyan Zhang

et al.

Water Research, Journal Year: 2023, Volume and Issue: 244, P. 120488 - 120488

Published: Aug. 14, 2023

Language: Английский

Citations

34
Multi-omics reveal microbial determinants impacting the treatment outcome of antidepressants in major depressive disorder DOI Creative Commons
Yaping Wang, Jingjing Zhou, Junbin Ye

et al.

Microbiome, Journal Year: 2023, Volume and Issue: 11(1)

Published: Aug. 28, 2023

Abstract Background There is a growing body of evidence suggesting that disturbance the gut-brain axis may be one potential causes major depressive disorder (MDD). However, effects antidepressants on gut microbiota, and role microbiota in influencing antidepressant efficacy are still not fully understood. Results To address this knowledge gap, multi-omics study was undertaken involving 110 MDD patients treated with escitalopram (ESC) for period 12 weeks. This conducted within cohort compared to reference group 166 healthy individuals. It found ESC ameliorated abnormal blood metabolism by upregulating MDD-depleted amino acids downregulating MDD-enriched fatty acids. On other hand, use showed relatively weak inhibitory effect leading reduction microbial richness functions. Machine learning-based integrative analysis revealed contributed changes plasma metabolites associated several such as tryptophan its microbiota-derived metabolite, indole-3-propionic acid (I3PA). Notably, significant correlation observed between baseline clinical remission at week 12. Compared non-remitters, individuals who achieved had higher richness, lower dysbiosis score, more complex well-organized community structure bacterial networks their microbiota. These findings indicate resilient remitters. Furthermore, we also demonstrated it composition itself, but rather presence sporulation genes could predict likelihood following treatment. The predictive model based these an area under curve (AUC) performance metric 0.71. Conclusion provides valuable insights into mechanism treatment MDD. represent advancement understanding intricate relationship among antidepressants, metabolome. Additionally, offers microbiota-centered perspective can potentially improve practice. By shedding light interplay factors, research contributes our broader mechanisms underlying opens new avenues optimizing therapeutic approaches.

Language: Английский

Citations

32
Parabens as environmental contaminants of aquatic systems affecting water quality and microbial dynamics DOI Creative Commons
Ana Rita Pereira, Manuel Simões, Inês B. Gomes

et al.

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 905, P. 167332 - 167332

Published: Sept. 25, 2023

Among different pollutants of emerging concern, parabens have gained rising interest due to their widespread detection in water sources worldwide. This occurs because are used personal care products, pharmaceuticals, and food, which residues generated released into aquatic environments. The regulation the use varies across geographic regions, resulting diverse concentrations observed globally. Concentrations exceeding 100 μg/L been found wastewater treatment plants surface waters while drinking (DW) typically exhibit below 6 μg/L. Despite low levels, presence DW is a potential exposure route for humans, raising concerns both human health environmental microbiota. Although few studies reported alterations functions characteristics microbial communities following contaminants, impact by communities, particularly biofilm colonizers, remains largely understudied. review gathers most recent information on occurrence sources, as well effects organisms. interactions with reviewed first time, filling knowledge gaps paraben ecosystems disinfection tolerance antimicrobial resistance, implications public health.

Language: Английский

Citations

30