Nucleic Acids Research,
Journal Year:
2020,
Volume and Issue:
49(D1), P. D613 - D621
Published: Oct. 19, 2020
Abstract
WikiPathways
(https://www.wikipathways.org)
is
a
biological
pathway
database
known
for
its
collaborative
nature
and
open
science
approaches.
With
the
core
idea
of
scientific
community
developing
curating
knowledge
in
models,
lowers
all
barriers
accessing
using
content.
Increasingly
more
content
creators,
initiatives,
projects
tools
have
started
WikiPathways.
Central
this
growth
increased
use
are
various
communities
that
focus
on
particular
subsets
molecular
pathways
such
as
rare
diseases
lipid
metabolism.
Knowledge
from
published
figures
helps
prioritize
development,
optical
character
named
entity
recognition.
We
show
over
last
three
years,
highlight
new
collaborations
authors
curators,
describe
technologies
to
connect
external
resources
initiatives.
The
road
toward
sustainable,
community-driven
goes
through
integration
with
other
Wikidata
allowing
use,
curation
redistribution
Chemosphere,
Journal Year:
2017,
Volume and Issue:
174, P. 437 - 446
Published: Jan. 26, 2017
A
large
number
of
emerging
contaminants
(ECs)
are
known
to
persist
in
surface
waters,
and
create
pressure
on
wastewater
treatment
works
(WWTW)
for
their
effective
removal.
Although
a
database
the
levels
these
pollutants
water
systems
exist
globally,
there
is
still
lack
correlation
with
possible
long-term
adverse
health
effects
wildlife
humans,
such
as
endocrine
disruption.
The
current
study
detected
total
55
ECs
WWTW
influent
water,
41
effluent,
40
environmental
waters
located
upstream
downstream
plant.
list
persisted
through
process,
28%
all
removed
by
less
than
50%,
18%
were
25%.
Negative
mass
balances
some
pharmaceuticals
metabolites
observed
within
WWTW,
suggesting
back-transformation
during
treatment.
Three
parental
illicit
drug
compounds
concentrations
ranging
between
27.6
147.0
ng
L-1
cocaine,
35.6-120.6
mephedrone,
270.9-450.2
methamphetamine.
related
risks
also
discussed
ECs,
particular
reference
ability
disrupt
systems.
propose
potential
carbamazepine,
naproxen,
diclofenac
ibuprofen
be
regarded
priority
monitoring
due
regular
detection
persistence
contribution
towards
humans
wildlife.
Toxicological Sciences,
Journal Year:
2014,
Volume and Issue:
142(2), P. 312 - 320
Published: Dec. 1, 2014
An
adverse
outcome
pathway
(AOP)
is
a
conceptual
framework
that
organizes
existing
knowledge
concerning
biologically
plausible,
and
empirically
supported,
links
between
molecular-level
perturbation
of
biological
system
an
at
level
organization
regulatory
relevance.
Systematic
information
into
AOP
frameworks
has
potential
to
improve
decision-making
through
greater
integration
more
meaningful
use
mechanistic
data.
However,
for
the
scientific
community
collectively
develop
useful
knowledgebase
encompasses
toxicological
contexts
concern
human
health
ecological
risk
assessment,
it
critical
AOPs
be
developed
in
accordance
with
consistent
set
core
principles.
Based
on
experiences
discourse
among
group
practitioners,
we
propose
five
fundamental
principles
guide
development:
(1)
are
not
chemical
specific;
(2)
modular
composed
reusable
components—notably
key
events
(KEs)
event
relationships
(KERs);
(3)
individual
AOP,
single
sequence
KEs
KERs,
pragmatic
unit
development
evaluation;
(4)
networks
multiple
share
common
KERs
likely
functional
prediction
most
real-world
scenarios;
(5)
living
documents
will
evolve
over
time
as
new
generated.
The
goal
present
article
was
introduce
some
strategies
detail
rationale
behind
these
5
Consideration
addresses
many
current
uncertainties
regarding
its
application
intended
foster
consistency
development.
ACS Nano,
Journal Year:
2018,
Volume and Issue:
12(11), P. 10582 - 10620
Published: Nov. 2, 2018
Graphene
and
its
derivatives
are
heralded
as
"miracle"
materials
with
manifold
applications
in
different
sectors
of
society
from
electronics
to
energy
storage
medicine.
The
increasing
exploitation
graphene-based
(GBMs)
necessitates
a
comprehensive
evaluation
the
potential
impact
these
on
human
health
environment.
Here,
we
discuss
synthesis
characterization
GBMs
well
environmental
hazard
assessment
using
vitro
vivo
model
systems
aim
understand
properties
that
underlie
biological
effects
materials;
not
all
alike,
it
is
essential
disentangle
structure–activity
relationships
for
this
class
materials.
Ecology,
Journal Year:
2015,
Volume and Issue:
97(2), P. 302 - 312
Published: Oct. 1, 2015
Anthropogenic
debris
contaminates
marine
habitats
globally,
leading
to
several
perceived
ecological
impacts.
Here,
we
critically
and
systematically
review
the
literature
regarding
impacts
of
from
scientific
fields
understand
weight
evidence
debris.
We
quantified
demonstrated
across
levels
biological
organization
that
make
up
ecosystem
found
366
threats
all
levels.
Two
hundred
ninety-six
these
were
tested,
83%
which
demonstrated.
The
majority
(82%)
due
plastic,
relative
other
materials
(e.g.,
metals,
glass)
largely
(89%)
at
suborganismal
molecular,
cellular,
tissue).
remaining
impacts,
higher
(i.e.,
death
individual
organisms,
changes
in
assemblages),
plastic
(>
1
mm;
e.g.,
rope,
straws,
fragments).
Thus,
show
debris,
but
conclude
quantity
quality
research
requires
improvement
allow
risk
be
determined
with
precision.
Still,
our
systematic
suggests
sufficient
exists
for
decision
makers
begin
mitigate
problematic
now,
avoid
irreversible
harm.
Chemical Research in Toxicology,
Journal Year:
2012,
Volume and Issue:
25(7), P. 1287 - 1302
Published: April 21, 2012
The
field
of
toxicology
is
on
the
cusp
a
major
transformation
in
how
safety
and
hazard
chemicals
are
evaluated
for
potential
effects
human
health
environment.
Brought
by
recognition
limitations
current
paradigm
terms
cost,
time,
throughput,
combined
with
ever
increasing
power
modern
biological
tools
to
probe
mechanisms
chemical–biological
interactions
at
finer
resolutions,
21st
century
rapidly
taking
shape.
A
key
element
new
approach
focus
molecular
cellular
pathways
that
targets
chemical
interactions.
By
understanding
toxicity
this
manner,
we
begin
learn
cause
toxicity,
as
opposed
merely
what
diseases
or
they
might
cause.
This
deeper
leads
confidence
identifying
which
populations
be
risk,
significant
susceptibility
factors,
influences
shape
dose–response
curve.
U.
S.
Environmental
Protection
Agency
(EPA)
initiated
ToxCast,
"toxicity
forecaster",
program
5
years
ago
gain
strengths
starting
test
relatively
large
numbers
(hundreds)
against
an
equally
number
assays.
Using
computational
approaches,
EPA
building
decision
support
based
ToxCast
vitro
screening
results
help
prioritize
further
investigation,
well
developing
predictive
models
outcomes.
perspective
provides
summary
initial,
proof
concept,
Phase
I
has
laid
groundwork
next
phases
future
directions
program.
