Assessing Contaminants of Emerging Concern in the Great Lakes Ecosystem: A Decade of Method Development and Practical Application DOI Creative Commons
Gerald T. Ankley, Steven R. Corsi, Christine M. Custer

et al.

Environmental Toxicology and Chemistry, Journal Year: 2023, Volume and Issue: 42(12), P. 2506 - 2518

Published: Aug. 29, 2023

Assessing the ecological risk of contaminants in field typically involves consideration a complex mixture compounds which may or not be detected via instrumental analyses. Further, there are insufficient data to predict potential biological effects many compounds, leading their being characterized as emerging concern (CECs). Over past several years, advances chemistry, toxicology, and bioinformatics have resulted variety concepts tools that can enhance pragmatic assessment CECs. The present Focus article describes 10+- year multiagency effort supported through U.S. Great Lakes Restoration Initiative assess occurrence implications CECs North American Lakes. State-of-the-science methods models were used evaluate more than 700 sites about approximately 200 tributaries across lakes Ontario, Erie, Huron, Michigan, Superior, sometimes on multiple occasions. Studies featured measurement up 500 different target analytes environmental matrices, coupled with evaluation resident species, animals from situ laboratory exposures, vitro systems. Experimental taxa included birds, fish, invertebrates, measured endpoints ranged molecular apical responses. Data integrated evaluated using diversity curated knowledgebases goal producing actionable insights for assessors managers charged evaluating mitigating This overview is based research captured 90 peer-reviewed journal articles reports, including 30 appearing virtual issue comprised highlighted papers published Environmental Toxicology Chemistry Integrated Assessment Management. Environ Toxicol Chem 2023;42:2506-2518. © 2023 SETAC. has been contributed by Government employees work public domain USA.

Language: Английский

The ToxCast pipeline: updates to curve-fitting approaches and database structure DOI Creative Commons
Madison Feshuk,

L. Kolaczkowski,

Kelly M. Dunham

et al.

Frontiers in Toxicology, Journal Year: 2023, Volume and Issue: 5

Published: Sept. 21, 2023

The US Environmental Protection Agency Toxicity Forecaster (ToxCast) program makes

Language: Английский

Citations

21
Potential for biological effects of per- and polyfluoroalkyl substances (PFAS) in Great Lakes tributaries and associations with land cover and wastewater effluent DOI Creative Commons
Steven R. Corsi, Luke C. Loken, Gerald T. Ankley

et al.

Environmental Toxicology and Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 6, 2025

Abstract Surface water concentrations of per- and polyfluoroalkyl substances (PFAS) potential for resulting biological effects were estimated in a study using Polar Organic Chemical Integrative Samplers (POCIS) from 60 tributary sites within 20 watersheds the Great Lakes Basin 2018. Sites represented range urban to agricultural, forested, wetland land uses included gradient wastewater treatment effluent zero 44% annual streamflow. Several also had airport influence. Twenty-one 32 targeted PFAS compounds detected POCIS samplers, which, 16 available sampling rates enabling time-weighted concentration estimates comparison with data. Estimated compared published quality guidelines (available nine PFAS), effect reported primary literature ECOTOX Knowledgebase apical endpoints (10 PFAS) non-apical vitro high-throughput screening data ToxCast (14 PFAS). Based on conservative evaluation approach that was weighted persistence limitations toxicological information, five individual PFAS, including Perfluorooctanesulfonic acid, Perfluorohexanesulfonic Perfluorobutanesulfonic Perfluorooctanoic Perfluorononanoic acid identified as warranting additional investigation. Possible increased potency mixtures over chemical effects, by summation exposure-activity ratios (EARs) chemicals influence common assays specified gene targets, indicated EAR values up 5.6-fold 14 contributing mixture predictions. Potential summed ratios, correlated use proportion streamflow contributed effluent.

Language: Английский

Citations

0
Factors contributing to pesticide contamination in riverine systems: The role of wastewater and landscape sources DOI Creative Commons
Samuel A. Miller, Kaycee E. Faunce, Larry B. Barber

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 954, P. 174939 - 174939

Published: July 24, 2024

Wastewater treatment plant (WWTP) discharges can be a source of organic contaminants, including pesticides, to rivers. An integrated model was developed for the Potomac River watershed (PRW) determine amount accumulated wastewater percentage streamflow (ACCWW) and calculate predicted environmental concentrations (PECs) 14 pesticides in non-tidal National Hydrography Dataset Plus Version 2.1 stream segments. Predicted were compared measured (MECs) from 32 sites that represented range ACCWW land use evaluate performance assess possible non-WWTP loading sources. Statistical agreement between PECs MECs strongest insecticides, followed by fungicides herbicides. Principal component analysis utilizing optical fluorescence ancillary water quality data identified urban runoff Pesticides indicated relatively larger sources WWTPs included dinotefuran, fipronil, carbendazim, thiabendazole, prometon whereas imidacloprid, azoxystrobin, propiconazole, tebuconazole, diuron more related runoff. In addition, generally comprised low proportion MECs, which indicates dominant beyond WWTP discharges. Cumulative potential toxicity higher with greater and/or located areas. Imidacloprid, carbendazim accounted largest portion across sites. The chronic aquatic life benchmarks freshwater invertebrates exceeded 82 % imidacloprid detections (n = 28) 47 fipronil 19). These results highlight ecological implications pesticide contamination also legacy effects soil groundwater Pesticide management strategies mitigate both current historical impacts may improve health ecosystems.

Language: Английский

Citations

3
Pesticide Prioritization by Potential Biological Effects in Tributaries of the Laurentian Great Lakes DOI Creative Commons
Samantha K. Oliver, Steven R. Corsi, Austin K. Baldwin

et al.

Environmental Toxicology and Chemistry, Journal Year: 2022, Volume and Issue: 42(2), P. 367 - 384

Published: Dec. 23, 2022

Abstract Watersheds of the Great Lakes Basin (USA/Canada) are highly modified and impacted by human activities including pesticide use. Despite labeling restrictions intended to minimize risks nontarget organisms, concerns remain that environmental exposures pesticides may be occurring at levels negatively impacting organisms. We used a combination organismal‐level toxicity estimates (in vivo aquatic life benchmarks) data from high‐throughput screening (HTS) assays vitro prioritize sites concern in streams 16 tributaries Basin. In or benchmark values were exceeded 15 sites, 10 which had exceedances throughout year. Pesticides greatest potential biological impact site with proportion agricultural land use its basin (the Maumee River, Toledo, OH, USA), 72 parent compounds transformation products being detected, 47 least one value. Our risk‐based approach identified multiple Lakes; these included: eight herbicides (metolachlor, acetochlor, 2,4‐dichlorophenoxyacetic acid, diuron, atrazine, alachlor, triclopyr, simazine), three fungicides (chlorothalonil, propiconazole, carbendazim), four insecticides (diazinon, fipronil, imidacloprid, clothianidin). present methods for reducing volume complexity effects result combining contaminant surveillance HTS vitro) traditional vivo) estimates. Environ Toxicol Chem 2023;42:367–384. Published 2022. This article is U.S. Government work public domain USA. Environmental Toxicology Chemistry published Wiley Periodicals LLC on behalf SETAC.

Language: Английский

Citations

12
A Highly Sensitive Electrochemical Immunosensor Based on PET/GO/pPd/MAb Nanofiber-Particles for Metolachlor Detection DOI
Yongbin Qin, Yani Jiang, Zichen Zheng

et al.

Electrochimica Acta, Journal Year: 2024, Volume and Issue: 509, P. 145336 - 145336

Published: Nov. 9, 2024

Language: Английский

Citations

1
Evaluating pharmaceuticals and other organic contaminants in the Lac du Flambeau Chain of Lakes using risk-based screening techniques DOI Creative Commons
Matthew A. Pronschinske, Steven R. Corsi,

Celeste Hockings

et al.

PLoS ONE, Journal Year: 2023, Volume and Issue: 18(6), P. e0286571 - e0286571

Published: June 2, 2023

In an investigation of pharmaceutical contamination in the Lac du Flambeau Chain Lakes (hereafter referred to as “the Chain”), few contaminants were detected; only eight pharmaceuticals and one pesticide identified among 110 other organic monitored surface water samples. This study, conducted cooperation with Tribe’s Water Resource Program, investigated these potential biological effects channels connecting lakes throughout Chain, including Moss Lake Outlet site, adjacent wastewater treatment plant lagoon. Of 6 sites 24 samples analyzed, sample concentrations contaminant detection frequencies greatest at site; however, this study comparable investigations basins similar characteristics. Because established water-quality benchmarks do not exist for detected alternative screening-level benchmarks, developed using two U.S. Environmental Protection Agency toxicological resources (ToxCast database ECOTOX knowledgebase), used estimate associated observed concentrations. Two (caffeine thiabendazole) exceeded prioritization threshold according ToxCast four (acetaminophen, atrazine, caffeine, carbamazepine) benchmarks. Atrazine, herbicide, was most frequently (79% samples), it exhibited strongest due its high estimated potency. Insufficient information within gabapentin methocarbamol (which had study) precluded benchmark development. data gap presents unknown environmental impacts. Future research examining elicited by well others would further elucidate ecological relevance chemistry results generated though investigation.

Language: Английский

Citations

2
Priority screening of contaminants of emerging concern (CECs) in surface water: Comparing cell-based bioassays and exposure-activity ratios (EARs) DOI Creative Commons

John P. Vanden Heuvel,

Megan Granda,

Francesca M. Ferguson

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 953, P. 176115 - 176115

Published: Sept. 10, 2024

Language: Английский

Citations

0
Priority Screening of Contaminants of Emerging Concern (Cecs) in Surface Water: Comparing Cell-Based Bioassays and Exposure-Activity Ratios (Ears) DOI

John P. Vanden Heuvel,

Megan Granda,

Francesca M. Ferguson

et al.

Published: Jan. 1, 2024

In this study, we compared a wide range of cell-based bioassays to the use chemical analysis followed by exposure-activity ratio (EAR) and Toxicological Prioritization index (ToxPi) for prioritizing chemicals, sites, hazard concerns in water samples. Surface samples were collected from nine sites three Central Pennsylvania streams analyzed targeted list compounds emerging concern (CECs), including pesticides, personal care products, pharmaceuticals. Cell-based reporter assays evaluated human zebrafish molecular initiating events (MIEs) endocrine metabolic disruption, altered lipid metabolism, oxidative stress. Bioassays showed that 29 out 40 had at least one site with activity over limit detection. The receptors exhibited highest number above effect-based trigger (EBT) values would be expected cause toxicity Aryl hydrocarbon receptor (AhR, zebrafish), Pregnane X Receptor (PXR), Estrogen Receptor-beta (ERB), Androgen (AR). Characterizing collection their bioactivity aligned closely stream which collected, Warriors Mark Run, Halfmoon, Spruce Run more similar than other streams. sum all EARs each indicated pharmaceutical Carbamazepine pesticides Carbaryl Atrazine posed greatest concern. However, predicted prioritization based on individual calculated EAR different those measured bioassay, indicating biologically active chemicals are present not included analytes. Taken together, these data show beneficial whereas mechanism-based inclusive known as well unknown contaminants thus overall quality prioritization.

Language: Английский

Citations

0
Influences of meteorological conditions, runoff, and bathymetry on summer thermal regime of a Great Lakes estuary DOI Creative Commons
Owen M. Stefaniak, Faith A. Fitzpatrick,

Brennan Dow

et al.

Journal of Great Lakes Research, Journal Year: 2024, Volume and Issue: 50(5), P. 102416 - 102416

Published: Aug. 22, 2024

Language: Английский

Citations

0
Assessing Contaminants of Emerging Concern in the Great Lakes Ecosystem: A Decade of Method Development and Practical Application DOI Creative Commons
Gerald T. Ankley, Steven R. Corsi, Christine M. Custer

et al.

Environmental Toxicology and Chemistry, Journal Year: 2023, Volume and Issue: 42(12), P. 2506 - 2518

Published: Aug. 29, 2023

Assessing the ecological risk of contaminants in field typically involves consideration a complex mixture compounds which may or not be detected via instrumental analyses. Further, there are insufficient data to predict potential biological effects many compounds, leading their being characterized as emerging concern (CECs). Over past several years, advances chemistry, toxicology, and bioinformatics have resulted variety concepts tools that can enhance pragmatic assessment CECs. The present Focus article describes 10+- year multiagency effort supported through U.S. Great Lakes Restoration Initiative assess occurrence implications CECs North American Lakes. State-of-the-science methods models were used evaluate more than 700 sites about approximately 200 tributaries across lakes Ontario, Erie, Huron, Michigan, Superior, sometimes on multiple occasions. Studies featured measurement up 500 different target analytes environmental matrices, coupled with evaluation resident species, animals from situ laboratory exposures, vitro systems. Experimental taxa included birds, fish, invertebrates, measured endpoints ranged molecular apical responses. Data integrated evaluated using diversity curated knowledgebases goal producing actionable insights for assessors managers charged evaluating mitigating This overview is based research captured 90 peer-reviewed journal articles reports, including 30 appearing virtual issue comprised highlighted papers published Environmental Toxicology Chemistry Integrated Assessment Management. Environ Toxicol Chem 2023;42:2506-2518. © 2023 SETAC. has been contributed by Government employees work public domain USA.

Language: Английский

Citations

0