Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(42), P. 28783 - 28794
Published: Oct. 11, 2024
Currently used drugs for glioblastoma (GBM) treatments are ineffective, primarily due to the significant challenges posed by strong drug resistance, poor blood-brain barrier (BBB) permeability, and lack of tumor specificity. Here, we report two cationic fluorescent anticancer agents (TriPEX-ClO
Language: Английский
Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 51(12), P. 4996 - 5041
Published: Jan. 1, 2022
This review systematically summarizes the research status, challenges, prospects, and potential bench-to-bedside translation of minimally invasive nanomedicines.
Language: Английский
Citations
289
Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)
Published: July 28, 2023
Abstract Glioblastoma (GBM) remains the most lethal malignant tumours. Gboxin, an oxidative phosphorylation inhibitor, specifically restrains GBM growth by inhibiting activity of F 0 1 ATPase complex V. However, its anti-GBM effect is seriously limited poor blood circulation, brain barrier (BBB) and non-specific tissue/cell uptake, leading to insufficient Gboxin accumulation at sites, which limits further clinical application. Here we present a biomimetic nanomedicine (HM-NPs@G) coating cancer cell-mitochondria hybrid membrane (HM) on surface Gboxin-loaded nanoparticles. An additional design element uses reactive oxygen species responsive polymer facilitate at-site release. The HM camouflaging endows HM-NPs@G with unique features including good biocompatibility, improved pharmacokinetic profile, efficient BBB permeability homotypic dual tumour cell mitochondria targeting. results suggest that achieve circulation (4.90 h versus 0.47 free Gboxin) (7.73% ID/g 1.06% shown Gboxin). Effective inhibition in orthotopic U87MG patient derived X01 stem xenografts female mice extended survival time negligible side effects are also noted. We believe represents promising treatment for tumours potential.
Language: Английский
Citations
85
Materials Today, Journal Year: 2023, Volume and Issue: 62, P. 296 - 326
Published: Jan. 1, 2023
Language: Английский
Citations
83
Advanced Drug Delivery Reviews, Journal Year: 2022, Volume and Issue: 185, P. 114268 - 114268
Published: April 8, 2022
Language: Английский
Citations
81
Biomaterials, Journal Year: 2022, Volume and Issue: 287, P. 121608 - 121608
Published: June 1, 2022
Language: Английский
Citations
79
Theranostics, Journal Year: 2022, Volume and Issue: 12(11), P. 4879 - 4903
Published: Jan. 1, 2022
In recent decades, extracellular vesicles (EVs), as bioactive cell-secreted nanoparticles which are involved in various physiological and pathological processes including cell proliferation, immune regulation, angiogenesis tissue repair, have emerged one of the most attractive nanotherapeutics for regenerative medicine. Herein we provide a systematic review latest progress EVs applications. Firstly, will briefly introduce biogenesis, function isolation technology EVs. Then, underlying therapeutic mechanisms native unmodified engineering strategies modified entities be discussed. Subsequently, main focus placed on repair regeneration applications organs brain, heart, bone cartilage, liver kidney, well skin. More importantly, current clinical trials medicine also highlighted. Finally, future challenges insightful perspectives currently developed EV-based biomedicine short, opened new horizons biologists, chemists, nanoscientists, pharmacists, clinicians, making possible powerful tools therapies
Language: Английский
Citations
77
Coordination Chemistry Reviews, Journal Year: 2022, Volume and Issue: 475, P. 214875 - 214875
Published: Oct. 14, 2022
Language: Английский
Citations
73
Small, Journal Year: 2022, Volume and Issue: 18(39)
Published: Aug. 25, 2022
Transition-metal dyshomeostasis has been identified as a critical pathogenic factor for the aggregates of amyloid-beta (Aβ) peptide, which is associated with onset and progression Alzheimer's disease (AD). Excessive transition-metal ions, especially copper ion (Cu2+ ), catalyze formation reactive oxygen species (ROS), triggering neuroinflammation neuronal cell apoptosis. Therefore, developing robust chelating agent can not only efficiently bind toxic Cu2+ , but also simultaneously scavenge over-generated ROS that urgently needed AD treatment. In this work, 2D niobium carbide (Nb2 C) MXene-based nano-chelator constructed its performance in suppressing -induced accumulation aggregated Aβ peptide acting nanozyme (MXenzyme) powerful antioxidant property to excess cellular explored, intrinsic mechanism revealed by computational simulation. Importantly, benign photothermal effect Nb2 C MXenzyme demonstrates facilitated permeability blood-brain barrier under near-infrared laser irradiation, conquering limitations most conventional anti-AD therapeutic agents. This work favorable strategy combating engineering MXenzyme-based neuroprotective nano-chelator, paves distinct insight extending biomedical applications MXenes treating dyshomeostasis-and ROS-mediated central nervous system diseases.
Language: Английский
Citations
71
Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)
Published: Dec. 8, 2023
Nanomedicine-based anti-neuroinflammation strategy has become a promising dawn of Parkinson's disease (PD) treatment. However, there are significant gaps in our understanding the therapeutic mechanisms antioxidant nanomedicines concerning pathways traversing blood-brain barrier (BBB) and subsequent inflammation mitigation. Here, we report nanozyme-integrated metal-organic frameworks with excellent activity chiral-dependent BBB transendocytosis as anti-neuroinflammatory agents for treatment PD. These chiral nanozymes synthesized by embedding ultra-small platinum (Ptzymes) into L-chiral D-chiral imidazolate zeolite (Ptzyme@L-ZIF Ptzyme@D-ZIF). Compared to Ptzyme@L-ZIF, Ptzyme@D-ZIF shows higher accumulation brains male PD mouse models due longer plasma residence time more traverse BBB, including clathrin-mediated caveolae-mediated endocytosis. factors contribute superior efficacy reducing behavioral disorders pathological changes. Bioinformatics biochemical analyses suggest that inhibits neuroinflammation-induced apoptosis ferroptosis damaged neurons. The research uncovers biodistribution, metabolic variances, outcomes nanozymes-integrated ZIF platforms, providing possibilities devising anti-PD drugs.
Language: Английский
Citations
70
ACS Nano, Journal Year: 2023, Volume and Issue: 17(5), P. 4358 - 4372
Published: Feb. 27, 2023
The synovial tissues under rheumatoid arthritis conditions are usually infiltrated by inflammatory cells, particularly M1 macrophages with aberrant redox homeostasis, which causes rapid deterioration of articular structure and function. Herein, we created an ROS-responsive micelle (HA@RH-CeOX) through the in situ host–guest complexation between ceria oxide nanozymes hyaluronic acid biopolymers, precisely delivered nanozyme clinically approved drug Rhein (RH) to proinflammatory macrophage populations inflamed tissues. abundant cellular ROS could cleave thioketal linker trigger release RH Ce. Specifically, Ce3+/Ce4+ pair present SOD-like enzymatic activity rapidly decompose alleviate oxidative stress macrophages, while inhibit TLR4 signaling both act a concerted manner induce their repolarization into anti-inflammatory M2 phenotype ameliorate local inflammation promote cartilage repair. Notably, rats bearing showed drastic increase M1-to-M2 ratio from 1:0.48 1:1.91 tissue significantly reduced cytokine levels including TNF-α IL-6 following intra-articular injection HA@RH-CeOX, accompanied efficient regeneration restored Overall, this study revealed approach modulate homeostasis reprogram polarization states micelle-complexed biomimetic enzymes, offers alternative opportunities for treatment arthritis.
Language: Английский
Citations
67