Overview of Caffeine Effects on Human Health and Emerging Delivery Strategies

Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(8), P. 1067 - 1067

Published: July 27, 2023

Caffeine is a naturally occurring alkaloid found in various plants. It acts as stimulant, antioxidant, anti-inflammatory, and even an aid pain management, several over-the-counter medications. This derived bioactive compound the best-known ingredient coffee other beverages, such tea, soft drinks, energy widely consumed worldwide. Therefore, it extremely important to research effects of this substance on human body. With mind, caffeine its derivatives have been extensively studied evaluate ability prevent diseases exert anti-aging neuroprotective effects. review intended provide overview caffeine’s cancer cardiovascular, immunological, inflammatory, neurological diseases, among others. The heavily researched area sports will also be discussed. Finally, recent advances development novel nanocarrier-based formulations, enhance bioavailability beneficial

Language: Английский

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Microvesicles-hydrogel breaks the cycle of cellular senescence by improving mitochondrial function to treat osteoarthritis

Journal of Nanobiotechnology, Journal Year: 2023, Volume and Issue: 21(1)

Published: Nov. 15, 2023

Osteoarthritis (OA) is an age-related disease characterised by the accumulation of senescent chondrocytes, which drives its pathogenesis and progression. Senescent cells exhibit distinct features, including mitochondrial dysfunction excessive release reactive oxygen species (ROS), are highly correlated lead to a vicious cycle increasing cells. Stem cell therapy has proven effective in addressing cellular senescence, however, it still issues such as immune rejection ethical concerns. Microvesicles (MVs) constitute primary mechanism through stem exerts effects, offering cell-free approach that circumvents these risks excellent anti-ageing potential. Nonetheless, MVs have short vivo half-life, their secretion composition varies considerably under diverse conditions. This study aims address constructing ROS-responsive hydrogel loaded with pre-stimulant MVs. Through responding ROS levels this intelligently releases MVs, enhancing function chondrocytes improving senescence.We employed Interferon-gamma (IFN-γ) cell-specific stimulus generate IFN-γ-microvesicles (iMVs) enhanced effects. Simultaneously, we developed carrier utilising 3-aminophenylboronic acid (APBA)-modified silk fibroin (SF) polyvinyl alcohol (PVA). served protect prolong longevity, facilitate intelligent release. In vitro experiments demonstrated Hydrogel@iMVs effectively mitigated improved function, antioxidant capacity. further substantiated capabilities [email protected] effect can be significantly appropriate pre-stimulation suitable carrier. Therefore, containing IFN-γ pre-stimulated iMVs target characteristics ageing OA for therapeutic purposes. Overall, novel regulating balance between fission fusion, was reduced, finally, alleviates promising strategy OA.

Language: Английский

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Nanotechnology in inflammation: cutting-edge advances in diagnostics, therapeutics and theranostics

Theranostics, Journal Year: 2024, Volume and Issue: 14(6), P. 2490 - 2525

Published: Jan. 1, 2024

Inflammatory dysregulation is intimately associated with the occurrence and progression of many life-threatening diseases.Accurate detection timely therapeutic intervention on inflammatory are crucial for effective therapy inflammation-associated diseases.However, clinical outcomes inflammation-involved disorders still unsatisfactory.Therefore, there an urgent need to develop innovative anti-inflammatory strategies by integrating emerging technological innovations traditional therapeutics.Biomedical nanotechnology one promising fields that can potentially transform diagnosis treatment inflammation.In this review, we outline recent advances in biomedical inflammation, special attention paid nanosensors nanoprobes precise inflammation-related diseases, nanotherapeutics, as well nanotheranostics combined applications.Moreover, prospects challenges translation nanomedicines highlighted.

Language: Английский

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In Situ Reaction-Generated Aldehyde-Scavenging Polypeptides-Curcumin Conjugate Nanoassemblies for Combined Treatment of Spinal Cord Injury

ACS Nano, Journal Year: 2024, Volume and Issue: 18(10), P. 7346 - 7362

Published: Feb. 28, 2024

The microenvironment after traumatic spinal cord injury (SCI) involves complex pathological processes, including elevated oxidative stress, accumulated reactive aldehydes from lipid peroxidation, excessive immune cell infiltration, etc. Unfortunately, most of current neuroprotection therapies cannot cope with the intricate pathophysiology SCI, leading to scant treatment efficacies. Here, we developed a facile in situ reaction-induced self-assembly method prepare aldehyde-scavenging polypeptides (PAH)-curcumin conjugate nanoassemblies (named as PFCN) for combined SCI. prepared PFCN could release PAH and curcumin response acidic SCI microenvironment. Subsequently, exhibited an effectively neuroprotective effect through scavenging toxic well nitrogen oxygen species neurons, modulating microglial M1/M2 polarization, down-regulating expression inflammation-related cytokines inhibit neuroinflammation. intravenous administration significantly ameliorate malignant injured cord, protect promote motor function recovery contusive rat model.

Language: Английский

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Blood–Brain Barrier-Penetrative Fluorescent Anticancer Agents Triggering Paraptosis and Ferroptosis for Glioblastoma Therapy

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(42), P. 28783 - 28794

Published: Oct. 11, 2024

Currently used drugs for glioblastoma (GBM) treatments are ineffective, primarily due to the significant challenges posed by strong drug resistance, poor blood-brain barrier (BBB) permeability, and lack of tumor specificity. Here, we report two cationic fluorescent anticancer agents (TriPEX-ClO

Language: Английский

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