Toxic Metal Detection in Various Types of Tea from Certain Regions of China: Spatial Pollution Characteristics and Potential Health Risk Assessment DOI

Peiyu Guo,

Yunpeng Li, Justyna Miszczyk

et al.

ACS Earth and Space Chemistry, Journal Year: 2023, Volume and Issue: 7(2), P. 523 - 530

Published: Feb. 7, 2023

Tea is one of the most popular beverages in world, but toxic metals tea could threaten human health. The metal pollution status China at a national level remains unclear. Here, we detected cadmium (Cd) and arsenic (As) concentrations collected from 22 provinces China. major points are following: (1) average Cd As samples were 1.163 0.485 mg/kg, respectively; not levels exceeded standards Ministry Agriculture People's Republic (NY 659-2003). higher Southern Western regions 5.730, 0.071 0.510, 0.580 respectively, compared with Eastern Northern 0.203, 0.040 0.455, 0.463, respectively. concentration was highest kuding 21.98 whereas jasmine 0.76 mg/kg. (2) health risk assessment yielded target hazard quotients for 0.1989 0.1432, total index 0.3421, cancer 8.949 × 10–4. (3) principal component analysis revealed areas, which may be related to mining activities. This first national-scale investigation across Our findings provide useful reference ensuring quality safety production suggest need constant monitoring limit exceeding permitted limits.

Language: Английский

Potential of phenolic compounds in Ligustrum robustum (Rxob.) Blume as antioxidant and lipase inhibitors: Multi‐spectroscopic methods and molecular docking DOI
Haoxiang Gao, Hengyu Liang, Nan Chen

et al.

Journal of Food Science, Journal Year: 2022, Volume and Issue: 87(2), P. 651 - 663

Published: Jan. 17, 2022

Ligustrum robustum (Rxob.) Blume is traditionally served as a functional tea in China. In this work, the antioxidant activities of L. extract (LRE) were evaluated and its inhibitory effect mechanism on pancreatic lipase further investigated. With high contents phenols (139.70 ± 1.41 mg gallic acid equivalent/g extract) flavonoids (326.46 7.36 rutin extract), LRE showed significant (p < 0.05) for scavenging free radicals hydrogen peroxide, inhibiting lipid peroxidation providing strong reducing power. Meanwhile, displayed remarkable activity with low half-effective concentration (IC50 ) 2.469 0.005 mg/ml which was determined non-competitive inhibition. The spectroscopic results that inhibited by modifying tertiary secondary structures lipase. Moreover, four phenolic compounds (acteoside, lipedoside A, oleuropein ligurobustoside C) identified from performance liquid chromatography-quadrupole- time flight-mass spectrometry. addition, according to molecular docking analysis, could interact bonds, so change spatial structure inhibit catalytic activity. present suggest not only exhibits capacity but possesses effectively lipase, might have potential be developed food nutraceuticals prevention metabolic diseases. PRACTICAL APPLICATION: has been confirmed possess activity, indicates prevent oxidative stress regulate fat metabolism. This work suggests can novel resource prepare industries.

Language: Английский

Citations

23
Comparison analysis of bioactive constituents and heavy metals among original plants of Kuding tea from the genus Ilex DOI Creative Commons
Hui Liu, Xiao Hu, Mingyi Hu

et al.

Arabian Journal of Chemistry, Journal Year: 2024, Volume and Issue: 17(9), P. 105914 - 105914

Published: July 19, 2024

Kuding tea (KT) is the general name of a set bitter-tasting herbal made from varied original plant species. However, limited information was reported about difference bioactive constituents, heavy metals, and bioactivities among those In present study, comparison analyses polysaccharides, phenolics, flavonoids, saponins as well antioxidant antidiabetic activities were performed through colorimetry, UPLC-QTOF-MS, enzymatic assay molecular docking techniques on six KT plants mainly genus Ilex. Results showed that Cd contents in four other than Ilex pubescens (IP) cornuta (IC) metal including Pb, Cu, As Hg all lower standard limit values. Furthermore, carbohydrate polysaccharides (470.06 548.51 mg GLE/g), total phenolics (33.84 48.85 GAE/g), flavonoids (30.86 109.97 RE/g), phenolic acids (49.68 61.48 CAE/g), flavonols (18.47 19.19 flavanols (0.18 0.14 CE/g), (90.81 97.33 GSE /g) IP Ligustrum japonicum (LJ), their activity levels (IC50 607.41–780.44, 547.06–754.00 mg/L) significantly higher plants. Moreover, 6 9 compounds tentatively characterized LJ, respectively, dynamics simulation further used to analysis interaction between α-glucosidase IP. At last, principal component, hierarchical cluster, correlation indicated content phenols, main influencing factors abilities. Overall, according our systematic analysis, possessed highest potentials, thus might be better for development utilization.

Language: Английский

Citations

4
Chemical components, health-promoting effects and industrial application of a Chinese bitter tea (Kuding tea): A comprehensive review DOI
Xiaoze Liu, Xue Lin, Fei Tao

et al.

Food Chemistry, Journal Year: 2025, Volume and Issue: 479, P. 143792 - 143792

Published: March 8, 2025

Language: Английский

Citations

0
Astilbin ameliorates oxidative stress and apoptosis in D-galactose-induced senescence by regulating the PI3K/Akt/m-TOR signaling pathway in the brains of mice DOI
Yue Zhang, Chuanbo Ding,

Yuan Cai

et al.

International Immunopharmacology, Journal Year: 2021, Volume and Issue: 99, P. 108035 - 108035

Published: Aug. 12, 2021

Language: Английский

Citations

22
LncRNA XIST promotes insulin resistance in gestational diabetes mellitus via the microRNA-181b-5p/NDRG2 axis DOI Open Access

Yanli Xu,

Xiaodi Kang,

Huafang Liu

et al.

General Physiology and Biophysics, Journal Year: 2023, Volume and Issue: 42(05), P. 443 - 455

Published: Jan. 1, 2023

Many studies have explored the role of lncRNA X inactivation-specific transcript (XIST) in diabetes. This study was designed to unravel regulatory mechanism XIST on animal models gestational diabetes mellitus (GDM) progression via microRNA (miR)-181b-5p/N-myc downstream-regulated gene 2 (NDRG2) axis. XIST, miR-181b-5p, and NDRG2 expression levels GDM mice were detected. The subjected gain- loss-of-function assays examine change glucose metabolism indices (fasting blood (FBG), fasting insulin (FINS) homeostasis model assessment resistance (HOMA-IR)), serum oxidative stress factors (glutathione (GSH), superoxide dismutase (SOD), malondialdehyde (MDA)), inflammatory (interleukin-1 β (IL-1β), IL-6, tumor necrosis factor α (TNF-α)), pathological changes pancreatic tissues, apoptotic cells islets mice. elevated while miR-181b-5p depleted Down-regulated or up-regulated reduced FBG level, HOMA-IR, IL-1β, TNF-α, MDA contents, FINS, GSH, SOD mitigated decelerated Silenced dampens modulation miR-181b-5p/NDRG2

Language: Английский

Citations

8
Constituent-Taste Relationship of Kuding Tea Fermented by Aspergillus neoniger and Aspergillus cristatus: Unveiling taste Characteristics through Untargeted Metabolomics DOI
Zhaoxiang Zeng, Chengwu Song,

Xiaoliu Hu

et al.

Food Bioscience, Journal Year: 2024, Volume and Issue: 62, P. 105027 - 105027

Published: Sept. 1, 2024

Language: Английский

Citations

3
Metagenomic and Untargeted Metabolomic Analysis of the Effect of Sporisorium reilianum Polysaccharide on Improving Obesity DOI Creative Commons
Yunlong Guo, Meihong Liu, Xin Liu

et al.

Foods, Journal Year: 2023, Volume and Issue: 12(8), P. 1578 - 1578

Published: April 7, 2023

Gut microbiota plays an important role in the pathophysiology of obesity. Fungal polysaccharide can improve obesity, but potential mechanism needs further study. This experiment studied polysaccharides from Sporisorium reilianum (SRP) to obesity male Sprague Dawley (SD) rats fed with a high-fat diet (HFD) using metagenomics and untargeted metabolomics. After 8 weeks SRP (100, 200, 400 mg/kg/day) intervention, we analyzed related index gut microbiota, metabolomics rats. The serum lipid levels treated were reduced, accumulation liver adipocyte hypertrophy was improved, especially high dose SRP. improved composition function diet, decreased ratio Firmicutes Bacteroides at phylum level. At genus level, abundance Lactobacillus increased that decreased. species crispatus, helveticus, acidophilus increased, while reuteri Staphylococcus xylosus mainly regulated metabolism amino acid metabolism. indicated 36 metabolites anti-obesity effect Furthermore, linoleic metabolism, phenylalanine, tyrosine, tryptophan biosynthesis, phenylalanine pathway played improving those study results suggest significantly alleviated via gut-microbiota-related metabolic pathways, could be used for prevention treatment

Language: Английский

Citations

7
Preventive effect of small‐leaved Kuding tea (Ligustrum robustum) on high‐diet‐induced obesity in C57BL/6J mice DOI Creative Commons

Ya Wu,

Jun Yang, Xiaojing Liu

et al.

Food Science & Nutrition, Journal Year: 2020, Volume and Issue: 8(8), P. 4512 - 4522

Published: July 8, 2020

Abstract Small‐leaved Kuding tea (SLKDT; Ligustrum robustum ) is a traditional Chinese tea. We systematically investigated the effect of SLKDT extract on obesity. SLKDT‐controlled weight gain in mice fed high‐fat diet. Tissue specimen results showed that alleviated liver damage and fat accumulation. Meanwhile, improved dyslipidemia by decreasing total cholesterol, triglycerides, low‐density lipoprotein cholesterol levels increasing high‐density levels. Furthermore, reduced alanine aminotransferase, alkaline phosphatase, aspartate transaminase serum tissues; decreased inflammatory cytokines, including interleukin (IL)‐1β, tumor necrosis factor‐α, interferon‐γ, IL‐6; increased anti‐inflammatory IL‐4 IL‐10. The quantitative PCR upregulated mRNA expressions peroxisome proliferator‐activated receptor (PPAR)‐α, lipase, carnitine palmitoyltransferase 1, 7 alpha hydroxylase downregulated PPAR‐γ CCAAT/enhancer‐binding protein‐alpha obese mouse livers to reduce adipocyte differentiation accumulation, promote oxidation, improve dyslipidemia, thereby inhibiting immune response alleviating injury. shows potential for preventing obesity regulating obesity‐related syndrome, so it possible be further developed as novel treatment fighting

Language: Английский

Citations

19
Determination of Polyphenols in Ilex kudingcha and Insect Tea (Leaves Altered by Animals) by Ultra-high-performance Liquid Chromatography-Triple Quadrupole Mass Spectrometry (UHPLC-QqQ-MS) and Comparison of Their Anti-Aging Effects DOI Creative Commons
Jianfei Mu,

Fuping Yang,

Fang Tan

et al.

Frontiers in Pharmacology, Journal Year: 2021, Volume and Issue: 11

Published: Jan. 21, 2021

Ilex kudingcha C.J. Tseng tea and insect tea, as traditional Chinese teas, are favored for their original craftsmanship, unique flavor, biological functionality. In this study, ultra high-performance liquid chromatography-triple quadrupole mass spectrometry (UHPLC-QqQ-MS) was used to analyze the bioactive components of extracts , D-galactose-induced aging mice were compare in vivo anti-aging effects extracts. The results remarkable, UHPLC-QqQ-MS analysis showed that ITP contains 29 ingredients, while IKDCP 26 ingredients. However, due large differences content main chemical ITP, equally different. At same time, research suggesting (500 mg/kg) include regulation viscera indices major organs; improvement liver, skin, spleen tissue morphology; decreased production inflammatory cytokines; up SOD, CAT, GSH, GSH-PX T-AOC down NO MDA levels serum liver tissue; reductions concentration pro-inflammatory factors, increases anti-inflammatory factor. RT-qPCR western blot assay also affect by regulating gene protein expression GSH-PX, GSH1, SOD1, SOD2 CAT . overall indicate is more effective treating oxidative damage induced D-galactose. Thus, appears be an functional drink owing its rich nutritional activities.

Language: Английский

Citations

14
Chemical Constituents from the Leaves of Ligustrum robustum and Their Bioactivities DOI Creative Commons

Shi-Hui Lu,

Haojiang Zuo, Jing Huang

et al.

Molecules, Journal Year: 2023, Volume and Issue: 28(1), P. 362 - 362

Published: Jan. 2, 2023

The leaves of Ligustrum robustum have been consumed as Ku-Ding-Cha for clearing heat and removing toxins, they used a folk medicine curing hypertension, diabetes, obesity in China. phytochemical research on the L. led to isolation identification two new hexenol glycosides, butenol five sugar esters, named ligurobustosides X (1a), X1 (1b), Y (2a), Y1 (2b) ligurobustates A (3a), B (3b), C (4b), D (5a), E (5b), along with seven known compounds (4a 6-10). Compounds 1-10 were tested their inhibitory effects fatty acid synthase (FAS), α-glucosidase, α-amylase, well antioxidant activities. Compound 2 showed strong FAS activity (IC50 4.10 ± 0.12 μM) close that positive control orlistat 4.46 0.13 μM); 7 9 revealed moderate α-glucosidase activities; α-amylase 1 10 displayed stronger 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) ammonium salt (ABTS) radical scavenging 3.41 0.08~5.65 0.19 than l-(+)-ascorbic 10.06 μM). This study provides theoretical foundation functional tea prevent diabetes its complications.

Language: Английский

Citations

5