Molecular Biology Reports, Journal Year: 2025, Volume and Issue: 52(1)
Published: April 15, 2025
Language: Английский
Biology, Journal Year: 2024, Volume and Issue: 13(7), P. 519 - 519
Published: July 12, 2024
Glycolipid metabolic disorders (GLMDs) are various resulting from dysregulation in glycolipid levels, consequently leading to an increased risk of obesity, diabetes, liver dysfunction, neuromuscular complications, and cardiorenal vascular diseases (CRVDs). In patients with GLMDs, excess caloric intake a lack physical activity may contribute oxidative stress (OxS) systemic inflammation. This study aimed review the connection between GLMD, OxS, metainflammation, onset CRVD. GLMD is due causing dysfunction synthesis, breakdown, absorption glucose lipids body, excessive ectopic accumulation these molecules. mainly neuroendocrine dysregulation, insulin resistance, metainflammation. many inflammatory markers defense cells play vital role related tissues organs, such as blood vessels, pancreatic islets, liver, muscle, kidneys, adipocytes, promoting lesions that affect interconnected organs through their signaling pathways. Advanced glycation end products, ATP-binding cassette transporter 1, Glucagon-like peptide-1, Toll-like receptor-4, sphingosine-1-phosphate (S1P) crucial since they glucolipid metabolism. The consequences this system organ damage morbidity mortality.
Language: Английский
Citations
23
Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 22, 2025
Language: Английский
Citations
1
BioChem, Journal Year: 2024, Volume and Issue: 4(3), P. 189 - 216
Published: July 29, 2024
Gastrointestinal diseases have been among the main concerns of medical and scientific societies for a long time. Several studies emphasized critical role oxidative stress in pathogenesis most common gastrointestinal diseases. To provide comprehensive overview caused by stress, their biological aspects, molecular mechanisms specific pathways, results recent published articles from online databases were studied considering both upper lower parts digestive tract. The revealed that although each part system manifests itself way, all these arise imbalance between generation reactive intermediates (especially oxygen species) antioxidant defense system. Annual incidence mortality statistics worldwide emphasize urgent need to find an effective non-invasive treatment method overcome life-threatening problems. Therefore, next step, variety nanomedicurfines developed treat effect investigated precisely. Furthermore, important nanomedicines responsive endogenous exogenous stimuli evaluated detail. This review could pave way open new horizon effectively treating
Language: Английский
Citations
5
Frontiers in Veterinary Science, Journal Year: 2024, Volume and Issue: 11
Published: Aug. 7, 2024
Oxidative damage resulting from weaning stress significantly impacts the growth performance and health status of piglets. Taurine, a dietary antioxidant with diverse functions, was investigated in this study for its protective role against stress-induced oxidative underlying mechanism. Forty 28-day-old male castrated weaned piglets were randomly assigned to four groups. The control group received basal diet, while experimental groups fed diet supplemented 0.1, 0.2%, or 0.3% taurine over 28-day period.
Language: Английский
Citations
5
ACS Chemical Neuroscience, Journal Year: 2024, Volume and Issue: 15(14), P. 2545 - 2564
Published: July 9, 2024
Alzheimer's disease (AD) is a progressive multifaceted neurodegenerative and remains formidable global health challenge. The current medication for AD gives symptomatic relief and, thus, urges us to look alternative disease-modifying therapies based on multitarget directed approach. Looking at the remarkable progress made in peptide drug development last decade benefits associated with peptides, they offer valuable chemotypes [multitarget ligands (MTDLs)] as therapeutics. This review recapitulates developments harnessing peptides MTDLs combating by targeting multiple key pathways involved disease's progression. hold immense potential represent convincing avenue pursuit of novel While hurdles remain, ongoing research offers hope that may eventually provide approach combat AD.
Language: Английский
Citations
4
Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15
Published: Sept. 5, 2024
Epilepsy, a complex neurological condition marked by recurring seizures, is increasingly recognized for its intricate relationship with mitochondria, the cellular powerhouses responsible energy production and calcium regulation. This review offers an in-depth examination of interplay between epilepsy, mitochondrial function, aging. Many factors might account correlation epilepsy Mitochondria, integral to dynamics neuronal excitability, perform critical role in pathophysiology epilepsy. The mechanisms linking mitochondria are multifaceted, involving dysfunction, reactive oxygen species (ROS), dynamics. Mitochondrial dysfunction can trigger seizures compromising ATP production, increasing glutamate release, altering ion channel function. ROS, natural byproducts respiration, contribute oxidative stress neuroinflammation, epileptogenesis. govern fusion fission processes, influence seizure threshold buffering, impact propagation. Energy demands during highlight generation maintaining membrane potential. handling dynamically modulates affecting synaptic transmission action potential generation. Dysregulated hallmark contributing excitotoxicity. Epigenetic modifications function through histone modifications, DNA methylation, non-coding RNA expression. Potential therapeutic avenues targeting include mitochondria-targeted antioxidants, ketogenic diets, metabolic therapies. concludes outlining future directions research, emphasizing integrative approaches, advancements ethical considerations. Mitochondria emerge as central players narrative offering profound insights this challenging disorder.
Language: Английский
Citations
4
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(22), P. 12166 - 12166
Published: Nov. 13, 2024
The widespread use of plastics has increased environmental pollution by micro- and nanoplastics (MNPs), especially polystyrene (PS-MNPs). These particles are persistent, bioaccumulative, linked to endocrine-disrupting toxicity, posing risks reproductive health. This review examines the effects PS-MNPs on mammalian systems, focusing oxidative stress, inflammation, hormonal imbalances. A comprehensive search in Web Science Core Collection, following PRISMA 2020 guidelines, identified studies impact fertility, including oogenesis, spermatogenesis, folliculogenesis. An analysis 194 publications revealed significant harm, such as reduced ovarian size, depleted follicular reserves, apoptosis somatic cells, disrupted estrous cycles females, along with impaired sperm quality imbalances males. were endocrine disruption, leading cellular molecular damage. Further research is urgently needed understand toxicity mechanisms, develop interventions, assess long-term health impacts across generations, highlighting need address these challenges given growing exposure.
Language: Английский
Citations
4
Regional Studies in Marine Science, Journal Year: 2025, Volume and Issue: 81, P. 104009 - 104009
Published: Jan. 1, 2025
Language: Английский
Citations
0
Journal of Fluorescence, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 10, 2025
Language: Английский
Citations
0
International Journal of Pharmacology, Journal Year: 2025, Volume and Issue: 21(1), P. 47 - 54
Published: Jan. 15, 2025
Language: Английский
Citations
0