Sprayable Nanocomposites Hydrogel for Wound Healing and Skin Regeneration DOI Open Access

Sihua Li,

Meng Luo,

Juntang Li

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 14, 2024

Abstract Wound management remains a critical challenge worldwide and imposes huge financial burden on every nation. Hydrogels are promising for biomedical applications because of their extracellular matrix (ECM) like structure, good biocompatibility multifunctional bioactivity. However, the poor mechanical properties inconvenient operation traditional hydrogels make it difficult to meet complex multifaceted needs clinical practice. In recent years, nanocomposites hydrogel with especially sprayable feature have shown enhanced facile operation, which enable value. A unique powerful nanocomposite (NCH) platform is developed by combining many advantages nanomaterials hydrogels, can achieve efficient trauma repair. This work reviews important advances preparation, functions NCH platforms. The challenges future trends in field aim providing researchers clarity past, present, emerging also proposed detail.

Language: Английский

Exploring the multimodal health‐promoting properties of resveratrol: A comprehensive review DOI Creative Commons
Zargham Faisal,

Aimen Mazhar,

Syeda Ayesha Batool

et al.

Food Science & Nutrition, Journal Year: 2024, Volume and Issue: 12(4), P. 2240 - 2258

Published: Jan. 28, 2024

Abstract Resveratrol, a natural polyphenol in various plants, has gained significant attention for its potential health‐promoting properties. It been demonstrated, after reviewing clinical and vitro studies, that resveratrol possesses potent antioxidant potential. Resveratrol demonstrates cellular component protection by directly neutralizing free radicals (FRs) enhancing the expression of enzymes, thereby mitigating oxidative damage to proteins, lipids, nucleic acids. Clinical trials have shown promising results, indicating supplementation can enhance defenses reduce markers populations. In addition effects, exhibits anti‐inflammatory modulate key inflammatory pathways, such as nuclear factor‐kappa B (NF‐κB) mitogen‐activated protein kinases (MAPKs), suppressing production pro‐inflammatory cytokines chemokines. Furthermore, resveratrol's multimodal effects extend beyond discovered exert regulatory on processes, including apoptosis, cell cycle progression, angiogenesis, immunological responses. The primary aim this review paper is provide thorough overview current knowledge resveratrol, chemical composition, bioaccessibility, effectiveness, utilization nanotechnology bioavailability. From future perspectives, revising administration methods certain contexts understanding underlying systems responsible will require further inquiry. For highest health advanced trial‐based research necessary combinational nano‐delivery resveratrol.

Language: Английский

Citations

14
Trends in Drug Repurposing: Advancing Cardiovascular Disease Management in Geriatric Populations DOI

Murali Krishna Moka,

Melvin George,

Deepalaxmi Rathakrishnan

et al.

Current Research in Translational Medicine, Journal Year: 2025, Volume and Issue: 73(2), P. 103496 - 103496

Published: Jan. 18, 2025

Language: Английский

Citations

1
Protective effects of resveratrol against PM2.5-induced damage in hNSCs and its mitigation of PM2.5-induced mitochondrial dysfunction in a 3D scaffold system DOI
Ming‐Chang Chiang, Christopher J.B. Nicol, Yuping Yang

et al.

Neuroscience, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

1
The effect of quercetin supplementation on the components of metabolic syndrome in adults: A systematic review and dose–response meta-analysis of randomized controlled trials DOI Creative Commons
Nooshin Noshadi,

Atefeh Bonyadian,

Ali Hojati

et al.

Journal of Functional Foods, Journal Year: 2024, Volume and Issue: 116, P. 106175 - 106175

Published: April 11, 2024

This systematic review and meta-analysis of randomized controlled trials (RCTs) sought to evaluate the effects quercetin on components (MetS) such as waist circumference (WC), systolic blood pressure (SBP), diastolic (DBP), fasting glucose (FBG), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C). A literature search up December 2023 was completed in Scopus, PubMed, Embase, Web Science, identify eligible RCTs. Altogether, 20 studies with a total sample size 1,164 subjects were included analysis. pooled analysis showed that consumption led significant reduction FBG (WMD: −1.03 mg/dL; 95 % CI: −1.87 −0.19), SBP −1.96 mmHg; −3.11 −0.81). However, there no TG, HDL-C, WC, DBP. It found intake can decrease significantly without other MetS.

Language: Английский

Citations

7
Resveratrol: A Review on the Biological Activity and Applications DOI Creative Commons

Ludovic Everard Bejenaru,

Andrei Biţă,

Ionela Belu

et al.

Applied Sciences, Journal Year: 2024, Volume and Issue: 14(11), P. 4534 - 4534

Published: May 25, 2024

Resveratrol (RSV), a naturally occurring phytoalexin, is the most important stilbenoid synthesized by plants as defense mechanism in response to microbial aggression, toxins, or ultraviolet radiation. RSV came attention of researchers both potential chemopreventive agent and possible explanation for low incidence cardiovascular disease (CVD) French people with high-fat diet. mainly administered food supplement, its properties are evaluated vitro vivo on various experimental models. modulates signaling pathways that limit spread tumor cells, protects nerve cells from damage, useful prevention diabetes, generally acts an anti-aging natural compound. It was highlighted could ameliorate consequences unhealthy lifestyle caused exaggerated caloric intake. This paper reviews evidence supporting beneficial effect pathological conditions, e.g., neoplastic diseases, neurodegeneration, metabolic syndrome, obesity, CVDs, immune bacterial, viral, fungal infections. The study also focused chromatographic analysis trans-RSV (tRSV) Romanian wine samples, providing comprehensive overview tRSV content across different types wine.

Language: Английский

Citations

6
Resveratrol: A Review on the Biological Activity and Applications DOI Open Access

Ludovic Everard Bejenaru,

Andrei Biţă,

Ionela Belu

et al.

Published: April 30, 2024

Resveratrol (RSV), a naturally occurring phytoalexin, is the most important stilbenoid synthesized by plants, as defense mechanism, in response to microbial aggression, toxins or ultraviolet radiation. RSV came attention of researchers both potential chemopreventive agent and possible explanation for low incidence cardiovascular disease (CVD) French people with high-fat diet. mainly administered food supplement, its properties being evaluated vitro vivo, on various experimental models. modulates signaling pathways that limit spread tumor cells, protects nerve cells from damage, useful prevention diabetes, generally acts an anti-aging natural compound. It was highlighted could ameliorate consequences unhealthy lifestyle caused exaggerated caloric intake. This paper reviews evidence supporting beneficial effect pathological conditions, e.g., neoplastic diseases, neurodegeneration, metabolic syndrome, obesity, CVDs, immune bacterial, viral, fungal infections. The study also focused chromatographic analysis trans-RSV (tRSV) Romanian wine samples, providing comprehensive overview tRSV content across different types wine.

Language: Английский

Citations

4
Resveratrol, a food-derived polyphenol, promotes Melanosomal degradation in skin fibroblasts through coordinated activation of autophagy, lysosomal, and antioxidant pathways DOI

Saki Okamoto,

Saya Kakimaru,

Mayuko Koreishi

et al.

Journal of Functional Foods, Journal Year: 2025, Volume and Issue: 125, P. 106672 - 106672

Published: Jan. 15, 2025

Language: Английский

Citations

0
The Vitamin D-Sirt1/PGC1α Axis Regulates Bone Metabolism and Counteracts Osteoporosis DOI Creative Commons

Cuicui Yang,

Lulu Chen, Xiaoli Guo

et al.

Journal of Orthopaedic Translation, Journal Year: 2025, Volume and Issue: 50, P. 211 - 222

Published: Jan. 1, 2025

Objective: Vitamin D insufficiency is a major contributor to osteoporosis. This study aimed elucidate the mechanisms by which vitamin D-Sirt1/PGC1α axis regulates bone metabolism and counteracts osteoporosis induced active insufficiency. Mouse models including Sirt1 transgenic (Sirt1Tg), Cyp27b1+/- (active deficient), compound Sirt1TgCyp27b1+/- mice were utilized. Bone parameters assessed radiography, micro-CT, histology, immunohistochemistry. In vitro studies used marrow-derived mesenchymal stem cells (BM-MSCs). Gene protein expression analyzed RT-PCR Western blotting. Chromatin immunoprecipitation luciferase assays investigated transcriptional regulation. Effects of resveratrol supplementation examined. 1,25-dihydroxyvitamin (1,25(OH)2D) caused downregulation expression, leading accelerated loss. Overexpression in corrected loss inhibiting oxidative stress, DNA damage, osteocyte senescence senescence-associated secretory phenotype, promoting osteoblastic formation, reducing osteoclastic resorption. 1,25(OH)2D3 transcriptionally upregulated BM-MSCs through receptor binding gene promoter. Resveratrol, agonist, attenuated 1,25(OH)2D modulating Sirt1/PGC1α axis. interacted with deacetylated PGC1α, coactivator involved mitochondrial biogenesis energy metabolism. Deacetylated PGC1α mediated effects on osteogenesis, cellular BM-MSCs. elucidated critical role regulating counteracting The findings highlight potential this as therapeutic target for prevention treatment

Language: Английский

Citations

0
Maternal Resveratrol Supplementation Attenuates Prenatal Stress Impacts on Anxiety- and Depressive-like Behaviors by Regulating Bdnf Transcripts Expression in the Brains of Adult Male Offspring Rats DOI Creative Commons

Gerardo Vera-Juárez,

Edgar Ricardo Vázquez-Martínez, Raquel Gómez‐Pliego

et al.

Brain Sciences, Journal Year: 2025, Volume and Issue: 15(2), P. 210 - 210

Published: Feb. 19, 2025

Prenatal stress has been reported to harm the physiological and biochemical functions of brain offspring, potentially resulting in anxiety- depression-like behaviors later life. Trans-Resveratrol (RESV) is known for its anti-inflammatory, anxiolytic, antidepressant properties. However, whether administering RESV during pregnancy can counteract induced by maternal unknown. This study aimed assess protective potential against molecular behavioral changes prenatal stress. During pregnancy, dams received 50 mg/kg BW/day orally. They underwent a movement restriction forty-five minutes, three times day, addition being exposed artificial light 24 h before delivery. The male offspring were left undisturbed until early adulthood, at which point they assessments, including open field test, elevated plus maze, forced swim test. Subsequently, euthanized, hippocampus prefrontal cortex extracted RT-qPCR analysis measure Bdnf mRNA expression. By weaning, results showed that led reduced weight gain and, increased these effects attenuated supplementation. findings suggest prevent modulating

Language: Английский

Citations

0
Post-traumatic stress disorder and metabolic syndrome: the role of some antioxidants in treatment DOI Creative Commons
Victoria Serhiyenko, A.Yu. Oliinyk, Yaroslav Pavlovskyi

et al.

INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine), Journal Year: 2024, Volume and Issue: 20(6), P. 470 - 480

Published: Nov. 9, 2024

The basis for the pathogenesis of cardiovascular, cancer, metabolic diseases, low-grade chronic inflammation (LGCI) and many other disorders is an imbalance between prooxidants antioxidant defense system. It believed that link post-traumatic stress disorder (PTSD) syndrome (MetS) based on oxidative (OS), increased autonomic nervous system activity, glucocorticoid synthesis activation, or immunological dysregulation. Moreover, pathophysiological changes in systemic LGCI pathways result from modifications receptor reactivity (secondary to emotional physiological arousal) may be inappropriate social behavior consistent with PTSD MetS manifestations. Recently, evidence has emerged suggesting a combination high levels OS activation plays important role PTSD. On hand, type recurrent long-term trauma exacerbates accele­rates cellular aging. accompanied by release reactive oxygen nitrogen species, proinflammatory cytokines, biologically active substances cause OS. purpose this review was discuss individual antioxidants, particular polyphenols, flavonoids, carotenoids, N-acetylcysteine, melatonin, L-arginine, C E vitamins, zinc, copper, selenium, prevention/treatment comorbid pathology MetS, as well analyze new trends directions future research. search conducted Scopus, Science Direct (from Else­vier) PubMed, including MEDLINE databases. keywords used were “post-traumatic disorder,” “metabolic syndrome,” “antioxidants.” To identify research results could not found during online search, manual bibliography publications used.

Language: Английский

Citations

3