The evaluation of L‐arginine solution as a solvent for propolis extraction: The phenolic profile, antioxidant, antibacterial activity, and in vitro bioaccessibility

Food Science & Nutrition, Journal Year: 2024, Volume and Issue: 12(4), P. 2724 - 2735

Published: Jan. 11, 2024

Abstract Ethanol has been widely used for the extraction of propolis. Due to its certain disadvantages, there an ongoing search find alternative non‐ethanolic solvents. This study aimed compare phenolics, antioxidant, and antibacterial activity propolis extracts prepared with 70% ethanol (EWE), propylene glycol (PGE), L‐arginine solution (BE). All were subjected in vitro simulated digestion procedure, phenolic profile non‐digested digested samples was determined by using LC–MS/MS. Additionally, change total (TPC), flavonoid content (TFC), antioxidant capacities at each phase. TPC TFC had similar values, although BE showed higher capacity ( p < .05). The amount reached or transformed intestinal stage PG compared EWE. also provided highest assay samples. most common phenolics pinocembrin, pinobanskin, galangin, CAPE extracts. However, their concentration drastically reduced digestion, recovery (R%) ranged from 0% 9.38% initial detected Chrysin bioaccessible all Among acids, R% trans‐cinnamic acid (22.14%) BE. inhibitory against Escherichia coli Staphylococcus aureus. suggests that could be as solvent extraction.

Language: Английский

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Liposomal propolis loaded xanthan gum-salep hydrogels: Preparation, characterization, and in vitro bioaccessibility of phenolics

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 140323 - 140323

Published: Jan. 1, 2025

Language: Английский

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Propolis-loaded liposomes: characterization and evaluation of the in vitro bioaccessibility of phenolic compounds

ADMET & DMPK, Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 5, 2024

Background and purpose: Propolis has low water solubility, poor stability, limited bioaccessibility of phenolic constituents when subjected to in vitro digestion. To overcome these drawbacks, the liposomal encapsulation method can be employed. Experimental approach: Soybean phosphatidylcholine lecithin mixed with Tween 80 (T80) ammonium phosphatides (AMP) was used produce propolis extract (PE)-loaded liposomes. The mean particle size, zeta potential, efficiency values, transmission electron microscopy analysis were characterize Individual phenolics determined for digested nondigested propolis-loaded liposomes extract. Key results: incorporation reduced size unloaded liposomes, whereas AMP inclusion yielded larger In both formulations, PE loading significantly increased potential values homogeneity distribution. free PE, most bioaccessible polyphenols acids (3.20 5.63 %), flavonoids such as caffeic acid phenethyl ester, galangin, pinobanksin, pinocembrin (0.03 2.12 %) least bioaccessible. Both provided higher compounds. T80 their compositions recovered 52.43 185.90 % total amount compounds samples, respectively. containing not only exhibited high solubility but also protection during Conclusion: Liposomal could a promising approach improving stability digestive fluids, making it suitable delivery oral formulations.

Language: Английский

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In-Depth Phytochemical Profile by LC-MS/MS, Mineral Content by ICP-MS, and In-Vitro Antioxidant, Antidiabetic, Antiepilepsy, Anticholinergic, and Antiglaucoma Properties of Bitlis Propolis

Life, Journal Year: 2024, Volume and Issue: 14(11), P. 1389 - 1389

Published: Oct. 29, 2024

Propolis is very significant in terms of its phytochemical content and biological activity among bee products. In this study, the antioxidant activities (total phenolic flavonoid, Fe

Language: Английский

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