Excision of mesenteric lymph nodes alters gut microbiota and impairs social dominance in adult mice DOI Creative Commons
Rui Yang,

Bo‐Ya Huang,

Yu‐Ning Wang

et al.

Brain and Behavior, Journal Year: 2023, Volume and Issue: 13(7)

Published: May 8, 2023

Introduction Mesenteric lymph nodes (MLNs) are central in immune anatomy. MLNs associated with the composition of gut microbiota, affecting system and system. Gut microbiota was found to differ among individuals different social hierarchies. Nowadays, excision is more frequently involved gastrointestinal surgery; however, potential side effects on dominance still unknown. Methods were removed from male mice (7–8 weeks old). Four after MLN removal, test performed investigate dominance; hippocampal serum interleukin (IL)‐1β, IL‐10, tumor necrosis factor‐alpha (TNF‐α) investigated; histopathology used evaluate local inflammation ileum. The then examined understand possible mechanism, finally intraperitoneal injection IL‐10 validate effect dominance. Results There a decrease operation group compared control group, as well levels, but no difference IL‐1β TNF‐α ileum removal. 16S rRNA sequencing analysis showed that relative abundance class Clostridia decreased group. This positively levels. Furthermore, subset increased Conclusions Our findings suggested contributed maintaining dominance, which might be reduced imbalance specific flora microbiota.

Language: Английский

Stress induced microglial activation contributes to depression DOI
Bingjin Li, Wei Yang, Tongtong Ge

et al.

Pharmacological Research, Journal Year: 2022, Volume and Issue: 179, P. 106145 - 106145

Published: Feb. 24, 2022

Language: Английский

Citations

81
Gut microbiota and neuropsychiatric disorders: Implications for neuroendocrine-immune regulation DOI
Tongtong Ge, Xiaoxiao Yao, Haisheng Zhao

et al.

Pharmacological Research, Journal Year: 2021, Volume and Issue: 173, P. 105909 - 105909

Published: Sept. 20, 2021

Language: Английский

Citations

34
Towards the convergent therapeutic potential of G protein‐coupled receptors in autism spectrum disorders DOI Creative Commons
Anil Annamneedi, Caroline Gora, Ana Dudas

et al.

British Journal of Pharmacology, Journal Year: 2023, Volume and Issue: unknown

Published: Aug. 14, 2023

Abstract Autism spectrum disorders (ASDs) are diagnosed in 1/100 children worldwide, based on two core symptoms: deficits social interaction and communication, stereotyped behaviours. G protein‐coupled receptors (GPCRs) the largest family of cell‐surface that transduce extracellular signals to convergent intracellular signalling downstream cellular responses commonly dysregulated ASD. Despite hundreds GPCRs being expressed brain, only 23 genetically associated with ASD according Simons Foundation Research Initiative (SFARI) gene database: oxytocin OTR; vasopressin V 1A 1B ; metabotropic glutamate mGlu 5 7 GABA B2 dopamine D 1 , 2 3 serotoninergic 5‐HT β ‐adrenoceptor; cholinergic M adenosine A 2A angiotensin AT cannabinoid CB chemokine CX CR1; orphan GPR37 GPR85; olfactory OR1C1, OR2M4, OR2T10 OR52M1. Here, we review therapeutic potential these GPCRs, as well for For each GPCR, discuss its genetic association, pharmacological manipulation animal models, pharmacopoeia symptoms rank them factors. Among highlight OTR more promising targets We dysregulation their is a pathological mechanism Their has begun multiple could mitigate

Language: Английский

Citations

15
Probiotic Bactolac alleviates depression-like behaviors by modulating BDNF, NLRP3 and MC4R levels, reducing neuroinflammation and promoting neural repair in rat model DOI Creative Commons
Musab Işık, Fadime Köse,

Özcan Budak

et al.

Pflügers Archiv - European Journal of Physiology, Journal Year: 2025, Volume and Issue: unknown

Published: April 26, 2025

Abstract Depression, a prevalent psychiatric disorder, exerts severe and debilitating impacts on an individual's mental physical well-being, it is considered chronic illness. Chronic stress plays important role in the pathophysiology of depression. Lactobacillus plantarum Streptococcus thermophilus are psychobiotic bacteria synthesize some neurotransmitters that play pathogenesis In this study, we aimed to investigate therapeutic effects Bactolac ( NBIMCC 8767 + 8258) stress-induced depression rats. Behavioral tests, including sucrose preference test, elevated plus maze forced swim three-chamber sociability were employed assess depressive anxiety-like behaviors. The expression level 5-HT1A, DRD1, ADRA-2A, GABA-A α1, CNR1, NR3C2, NOD1, NLRP3 MC4R; BDNF levels, glial activity intestinal permeability determined conclusions, decreased levels NOD1 level; increased MC4R, caused neurodegeneration activity, ultimately led effects. was effective reducing depressive-like behaviors according results behavioral tests. treatment provided high neuronal survival rate increasing level, prevented excessive release pro-inflammatory cytokines by therefore, activation hypothalamus–pituitary–adrenal (HPA) axis accordingly, reduced cell depressed We can suggest supplementation may be beneficial coping with stress, alleviate help protect health.

Language: Английский

Citations

0
Lycopene Alleviates Chronic Stress-Induced Hippocampal Microglial Pyroptosis by Inhibiting the Cathepsin B/NLRP3 Signaling Pathway DOI

Qiuxiang Zhu,

Zhicheng Gao,

Jinghui Peng

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2023, Volume and Issue: 71(50), P. 20034 - 20046

Published: Dec. 6, 2023

Lycopene (LYC) exerts a strong neuroprotective and antipyroptotic effects. This study explored the effects mechanisms of LYC on chronic stress-induced hippocampal microglial damage depression-like behaviors. The caspase-1 inhibitor VX-765 attenuated restrain stress (CRS)-induced pyroptosis Moreover, alleviation CRS-induced behaviors by was associated with cathepsin B/NLRP3 pathway. In vitro, Z-YVAD-FMK alleviated in highly aggressively proliferating immortalized (HAPI) cells. Additionally, corticosterone-induced HAPI cell Furthermore, B agonist pazopanib promoted pyroptosis, whereas inhibited pazopanib-induced via Similarly, pyroptosis. These results suggest that alleviates pathway inhibition. provides new strategy for treating encephalopathy.

Language: Английский

Citations

9
Repurposing Ketamine in the Therapy of Depression and Depression-Related Disorders: Recent Advances and Future Potential DOI Creative Commons

Qianting Deng,

Emily D. Parker,

Chongyun Wu

et al.

Aging and Disease, Journal Year: 2024, Volume and Issue: unknown, P. 0 - 0

Published: Jan. 1, 2024

Depression represents a prevalent and enduring mental disorder of significant concern within the clinical domain. Extensive research indicates that depression is very complex, with many interconnected pathways involved. Most related to focuses on monoamines, neurotrophic factors, hypothalamic-pituitary-adrenal axis, tryptophan metabolism, energy mitochondrial function, gut-brain glial cell-mediated inflammation, myelination, homeostasis, brain neural networks. However, recently, Ketamine, an ionotropic N-methyl-D-aspartate (NMDA) receptor antagonist, has been discovered have rapid antidepressant effects in patients, leading novel successful treatment approaches for mood disorders. This review aims summarize latest findings insights into various signaling systems observed patients animal models, providing more comprehensive view neurobiology anxious-depressive-like behavior. Specifically, it highlights key mechanisms ketamine as rapid-acting antidepressant, aiming enhance neuropsychiatric Moreover, we discuss potential prophylactic or therapeutic intervention stress-related psychiatric

Language: Английский

Citations

3
Cellular, synaptic, and network effects of chemokines in the central nervous system and their implications to behavior DOI Creative Commons
Joanna Ewa Sowa, Krzysztof Tokarski

Pharmacological Reports, Journal Year: 2021, Volume and Issue: 73(6), P. 1595 - 1625

Published: Aug. 26, 2021

Abstract Accumulating evidence highlights chemokines as key mediators of the bidirectional crosstalk between neurons and glial cells aimed at preserving brain functioning. The multifaceted role these immune proteins in CNS is mirrored by complexity mechanisms underlying its biological function, including biased signaling. Neurons, only concert with cells, are essential players modulation homeostatic functions. Yet, attempts to dissect complex multilevel coordination still lacking. Therefore, purpose this review summarize current knowledge about chemokine regulation neuron–glia linking molecular, cellular, network, behavioral levels. Following a brief description molecular which interact their receptors then summarizing cellular patterns expression CNS, we next delve into sequence chemokine-regulated communication context neuroprotection. We define interactions other neurotransmitters, neuromodulators, gliotransmitters. Finally, describe fine-tuning on network level relevance modulation. believe that better understanding nature events drive neuro-glial holds promise for development new treatment strategies could, context- time-dependent manner, modulate action specific promote repair reduce neurological impairment.

Language: Английский

Citations

22
Astrocytes regulate neuronal network activity by mediating synapse remodeling DOI

Namshik Kim,

Won‐Suk Chung

Neuroscience Research, Journal Year: 2022, Volume and Issue: 187, P. 3 - 13

Published: Sept. 25, 2022

Language: Английский

Citations

11
Astrocytes at the intersection of ageing, obesity, and neurodegeneration DOI
Wyn Firth, Katherine R. Pye, Paul G. Weightman Potter

et al.

Clinical Science, Journal Year: 2024, Volume and Issue: 138(8), P. 515 - 536

Published: April 1, 2024

Abstract Once considered passive cells of the central nervous system (CNS), glia are now known to actively maintain CNS parenchyma; in recent years, evidence for glial functions physiology and pathophysiology has only grown. Astrocytes, a heterogeneous group cells, play key roles regulating metabolic inflammatory landscape have emerged as potential therapeutic targets variety disorders. This review will outline astrocyte healthy ageing, obesity, neurodegeneration, with focus on responses mitochondrial function, address outlooks.

Language: Английский

Citations

2
The zinc finger transcription factor Sall1 is required for the early developmental transition of microglia in mouse embryos DOI Creative Commons
Earl Parker Scott,

Emma Breyak,

Ryuichi Nishinakamura

et al.

Glia, Journal Year: 2022, Volume and Issue: 70(9), P. 1720 - 1733

Published: May 14, 2022

Abstract Microglia play many critical roles in neural development. Recent single‐cell RNA‐sequencing studies have found diversity of microglia both across different stages and within the same stage developing brain. However, how such is controlled during development poorly understood. In this study, we first expression macrophage mannose receptor CD206 early‐stage embryonic on mouse brain sections. This showed a sharp decline between E12.5 E13.5 central nervous system. We next tested microglia‐expressed zinc finger transcription factor SALL1 early transition gene expression. By deleting Sall1 specifically microglia, that continued to express when it normally downregulated. addition, mutant show less ramified morphology comparison with controls even into postnatal stages. Thus, required for more mature status

Language: Английский

Citations

9