Astrocytic Foxo1 regulates hippocampal spinogenesis and synaptic plasticity to enhance fear memory DOI Open Access
João Filipe Viana, Sónia Guerra‐Gomes, Daniela Sofia Abreu

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: May 1, 2023

ABSTRACT Astrocytes are active players in brain circuits, sensing and responding to neuronal activity, impacting behavior production. Activation of astrocytes triggers intracellular calcium elevations displaying complex spatiotemporal properties. Intracellular activity is thought underlie synaptic transmission, metabolism, homeostasis modulation. However, the calcium-dependent signaling pathways involved these processes poorly understood, representing a critical knowledge gap this field. To reveal circuit structure function, we performed multi-level analysis inositol 1,4,5-triphosphate receptor type 2 knockout (IP3R2 KO) mouse model which lacks somatic specifically astrocytes. We focused on hippocampus, region responsible for cognitive function emotional behaviors. The transcriptomic hippocampal tissue revealed that lack astrocytic causes differential expression hundreds genes. Among these, 76 genes regulated by astrocyte-specific Foxo1 transcription factor. This factor over-expressed regulates spinogenesis coverage. A detailed morphological pyramidal neurons dendrites with shift more immature spine profile. profile may previously described reduction long-term depression performance fear memory tasks observed model. Indeed, confirmed mice lacking display an enhancement memory. verify causal relationship between structural, synaptic, behavioral observations, used viral approach induce over-expression naïve C57BL/6J mice. viral-driven stratum radiatum replicated crossing territory led same region. Finally, manipulation was sufficient enhance characterization modulate through

Language: Английский

Astrocyte morphology DOI Creative Commons
Katherine T. Baldwin, Keith K. Murai, Baljit S. Khakh

et al.

Trends in Cell Biology, Journal Year: 2023, Volume and Issue: 34(7), P. 547 - 565

Published: Oct. 26, 2023

Astrocytes are predominant glial cells that tile the central nervous system (CNS). A cardinal feature of astrocytes is their complex and visually enchanting morphology, referred to as bushy, spongy, star-like. precept this review such morphological shapes evolved allow contact signal with diverse at a range distances in order sample, regulate, contribute extracellular milieu, thus participate widely cell–cell signaling during physiology disease. The recent use improved imaging methods cell-specific molecular evaluations has revealed new information on structural organization underpinnings astrocyte mechanisms morphogenesis, contributions disease states reduced morphology. These insights have reignited interest complexity cornerstone fundamental biology critical substrate for multicellular spatial physiological interactions CNS.

Language: Английский

Citations

49
Computational modeling of neuron–glia signaling interactions to unravel cellular and neural circuit functioning DOI
Marja‐Leena Linne

Current Opinion in Neurobiology, Journal Year: 2024, Volume and Issue: 85, P. 102838 - 102838

Published: Feb. 3, 2024

Language: Английский

Citations

6
Analysis of Network Models with Neuron-Astrocyte Interactions DOI Creative Commons
Tiina Manninen, Jugoslava Aćimović, Marja‐Leena Linne

et al.

Neuroinformatics, Journal Year: 2023, Volume and Issue: 21(2), P. 375 - 406

Published: March 23, 2023

Abstract Neural networks, composed of many neurons and governed by complex interactions between them, are a widely accepted formalism for modeling exploring global dynamics emergent properties in brain systems. In the past decades, experimental evidence computationally relevant neuron-astrocyte interactions, as well astrocytic modulation neural dynamics, have accumulated. These findings motivated advances computational glioscience inspired several models integrating mechanisms into standard network formalism. were developed to study, example, synchronization, information transfer, synaptic plasticity, hyperexcitability, classification tasks hardware implementations. We here focus on at least two interacting bidirectionally with astrocytes that include explicitly modeled calcium dynamics. this we analyze evolution these biophysical, biochemical, cellular, used construct them. Based our analysis, propose how systematically describe categorize interaction schemes cells networks. additionally study view existing data present future perspectives. Our analysis is an important first step towards understanding contribution functions. However, more needed collect comprehensive about astrocyte morphology physiology vivo better integrate them data-driven models. Broadening discussion theoretical approaches expanding tools necessary understand astrocytes’ roles

Language: Английский

Citations

13
Neuron–Glial Interactions: Implications for Plasticity, Behavior, and Cognition DOI
Mauricio Rangel‐Gomez, Cristina M. Alberini,

Benjamin Deneen

et al.

Journal of Neuroscience, Journal Year: 2024, Volume and Issue: 44(40), P. e1231242024 - e1231242024

Published: Oct. 2, 2024

The traditional view of glial cells as mere supportive tissue has shifted, due to advances in technology and theoretical conceptualization, include a diversity other functions, such regulation complex behaviors. Astrocytes, the most abundant central nervous system (CNS), have been shown modulate synaptic functions through gliotransmitter-mediated neurotransmitter reuptake, influencing neuronal signaling behavioral functions. Contemporary studies further highlight astrocytes’ involvement cognitive For instance, inhibiting astrocytes hippocampus can lead memory deficits, suggesting their integral role processes. Moreover, astrocytic calcium activity astrocyte–neuron metabolic coupling linked changes strength learning. Microglia, another type cell, also extend beyond roles, contributing learning processes, with microglial reductions impacting these developmentally dependent manner. Oligodendrocytes, traditionally thought limited roles postdevelopment, are now recognized for activity-dependent modulation myelination plasticity, thus responses. Recent advancements computational modeling expanded our understanding particularly how influence circuits This review underscores importance CNS need research unravel complexities neuron–glia interactions, impact interactions on brain potential implications neurological diseases.

Language: Английский

Citations

5
Control of Ca2+ signals by astrocyte nanoscale morphology at tripartite synapses DOI
Audrey Denizot, Misa Arizono, U. Valentin Nägerl

et al.

Glia, Journal Year: 2022, Volume and Issue: 70(12), P. 2378 - 2391

Published: Sept. 13, 2022

Much of the Ca

Language: Английский

Citations

20
Ultrastructure of astrocytes using volume electron microscopy: A scoping review DOI Creative Commons

Vanessa Chiappini,

María Fernanda Veloz Castillo,

Francesco Biancardi

et al.

The Journal of Physiology, Journal Year: 2025, Volume and Issue: unknown

Published: March 3, 2025

Abstract The morphological features of astrocytes are crucial for brain homeostasis, synaptic activity and structural support, yet remain poorly quantified. As a result the nanometre‐sized cross‐section neuropil astrocytic processes, electron microscopy (EM) is only technique availabe to date capable revealing their finest morphologies. Volume EM (vEM) techniques, such as serial block‐face or focused ion beam scanning EM, enable high‐resolution imaging large fields allow more extensive 3‐D model analyses, new features. This scoping review aims summarize state art astrocyte ultrastructural analysis. included 45 439 non‐duplicated articles from Pubmed search, categorizing studies by research focus, animal models, region, vEM techniques segmentation methods. By answering classical questions volume, surface area, branching complexity ensheathment reported in literature, this work valuable resource scientists working on biology computational neuroscience. image

Language: Английский

Citations

0
Dynamic modeling of astrocyte-neuron interactions under the influence of Aβ deposition DOI

JiangNing Wang,

Xiaoli Yang

Cognitive Neurodynamics, Journal Year: 2025, Volume and Issue: 19(1)

Published: April 10, 2025

Language: Английский

Citations

0
Making time and space for calcium control of neuron activity DOI Creative Commons
Joanna Jędrzejewska‐Szmek, Daniel B. Dormán, Kim T. Blackwell

et al.

Current Opinion in Neurobiology, Journal Year: 2023, Volume and Issue: 83, P. 102804 - 102804

Published: Oct. 31, 2023

Language: Английский

Citations

10
Are cytoskeleton changes observed in astrocytes functionally linked to aging? DOI Creative Commons

Cristopher Villablanca,

René L. Vidal, Christian González‐Billault

et al.

Brain Research Bulletin, Journal Year: 2023, Volume and Issue: 196, P. 59 - 67

Published: March 17, 2023

Astrocytes are active participants in the performance of Central Nervous System (CNS) both health and disease. During aging, astrocytes susceptible to reactive astrogliosis, a molecular state characterized by functional changes response pathological situations, cellular senescence, loss cell division, apoptosis resistance, gain proinflammatory functions. This results two different states astrocytes, which can produce phenotypes with harmful consequences chronic conditions. Reactive senescent share morpho-functional features that dependent on organization cytoskeleton. However, such cytoskeleton have yet receive necessary attention explain their role alterations associated aging pathologies. In this review, we summarize all available findings connect aging. addition, discuss future avenues believe will guide novel topic.

Language: Английский

Citations

9
Revisiting astrocytic calcium signaling in the brain DOI Creative Commons
Ying Bai, Zhongqiu Zhou, Bing Han

et al.

Fundamental Research, Journal Year: 2024, Volume and Issue: 4(6), P. 1365 - 1374

Published: Feb. 8, 2024

Astrocytes, characterized by complex spongiform morphology, participate in various physiological processes, and abnormal changes their calcium (Ca2+) signaling are implicated central nervous system (CNS) disorders. However, medications targeting the control of Ca2+ have fallen short anticipated therapeutic outcomes clinical applications. This underscores fact that our comprehension this intricate regulation ions remains considerably incomplete. In recent years, with advancement labeling, imaging, analysis techniques, signals been found to exhibit high specificity at different spatial locations within structure astrocytes. has ushered study astrocytes into a new phase, leading several groundbreaking research achievements. Despite this, comprehensive understanding astrocytic implications challenging area for future research.

Language: Английский

Citations

3