Global Trends and Hotspots on Microglia Associated with Pain from 2002 to 2022: A Bibliometric Analysis DOI Creative Commons
Guoqi Dong, Hui Li, Gao Hui

et al.

Journal of Pain Research, Journal Year: 2023, Volume and Issue: Volume 16, P. 2817 - 2834

Published: Aug. 1, 2023

Researchers have made significant progress in microglia associated with pain recent years. However, more relevant bibliometric analyses are still needed on trends and directions this field. The aim of study is to provide a comprehensive perspective predict future pain-related research via tools.English articles reviews related were extracted from the Web Science core collection (WosCC) database between 2002 2022. Bibliometric tools such as VOSviewer, CiteSpace, Bibliometrix R package used analyze publication characteristics, countries, authors, institutions, journals, hotspots, trend topics.A total 2761 included analysis. Research has increased significantly over last two decades. China (n = 1020, 36.94%) United States 751, 27.20%) contributed most terms publications citations, respectively. Kyushu University published field compared other Professor Inoue Kazuhide 54) at university outstanding contributions Molecular Pain 113) was journal publication, while Journal Neuroscience had highest number citations. According authors keywords analysis, area can be summarized into 7 clusters "microglia activation pathways", "pain treatment research", "mental symptoms chronic pain", so on.This provides analysis past We identified scholars, journals influence field, paper may new insights for research.

Language: Английский

Tuning neural circuits and behaviors by microglia in the adult brain DOI Open Access
Shunyi Zhao, Anthony D. Umpierre, Long‐Jun Wu

et al.

Trends in Neurosciences, Journal Year: 2024, Volume and Issue: 47(3), P. 181 - 194

Published: Jan. 21, 2024

Language: Английский

Citations

42
Targeting Microglia in Neuroinflammation: H3 Receptor Antagonists as a Novel Therapeutic Approach for Alzheimer’s Disease, Parkinson’s Disease, and Autism Spectrum Disorder DOI Creative Commons
Shilu Deepa Thomas, Sabna Abdalla, Nermin Eissa

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(7), P. 831 - 831

Published: June 25, 2024

Histamine performs dual roles as an immune regulator and a neurotransmitter in the mammalian brain. The histaminergic system plays vital role regulation of wakefulness, cognition, neuroinflammation, neurogenesis that are substantially disrupted various neurodegenerative neurodevelopmental disorders. H3 receptor (H3R) antagonists inverse agonists potentiate endogenous release brain histamine have been shown to enhance cognitive abilities animal models several Microglial activation subsequent neuroinflammation implicated impacting embryonic adult neurogenesis, contributing development Alzheimer's disease (AD), Parkinson's (PD), autism spectrum disorder (ASD). Acknowledging importance microglia both neurodevelopment, well their by histamine, offers intriguing therapeutic target for these inhibition H3Rs has found facilitate shift from proinflammatory M1 state anti-inflammatory M2 state, leading reduction activity microglial cells. Also, pharmacological studies demonstrated H3R showed positive effects reducing biomarkers, suggesting potential simultaneously modulating crucial neurotransmissions signaling cascades such PI3K/AKT/GSK-3β pathway. In this review, we highlight addressing pathology decline disorders, e.g., AD, PD, ASD, with inflammatory component.

Language: Английский

Citations

9
Chemogenetic activation of microglial Gi signaling decreases microglial surveillance and impairs neuronal synchronization DOI Creative Commons
Shunyi Zhao, Lingxiao Wang, Dimitrios Kleidonas

et al.

Science Advances, Journal Year: 2025, Volume and Issue: 11(9)

Published: Feb. 28, 2025

Microglia actively survey the brain and dynamically interact with neurons to maintain homeostasis. Microglial Gi protein–coupled receptors (Gi-GPCRs) play a critical role in microglia-neuron communications. However, impact of temporally activating microglial signaling on dynamics neuronal activity homeostatic remains largely unknown. In this study, we used Gi-based designer exclusively activated by drugs (Gi-DREADD) selectively modulate pathway. By integrating chemogenetic approach vivo two-photon imaging, observed that exogenous activation transiently inhibited process dynamics, reduced activity, impaired synchronization. These altered functions were associated decrease interactions between microglia neuron somata. Together, study demonstrates acute, regulates circuit function, offering potential pharmacological target for neuromodulation through microglia.

Language: Английский

Citations

1
Obesity-associated microglial inflammatory activation paradoxically improves glucose tolerance DOI Creative Commons
John D. Douglass, Kelly M. Ness, Martín Valdearcos

et al.

Cell Metabolism, Journal Year: 2023, Volume and Issue: 35(9), P. 1613 - 1629.e8

Published: Aug. 11, 2023

Language: Английский

Citations

16
Placental ischemia during pregnancy induces hypertension, cerebral inflammation, and oxidative stress in dams postpartum DOI Creative Commons

Savanna Smith,

Jonna Smith,

Kylie Jones

et al.

Hypertension in Pregnancy, Journal Year: 2025, Volume and Issue: 44(1)

Published: Jan. 30, 2025

Preeclampsia (PE) is characterized as de novo hypertension (HTN) with end-organ damage, especially in the brain. PE hypothesized to be caused by placental ischemia. affects ~5-8% of USA pregnancies and increases risk for HTN cerebrovascular diseases (CVD) later life. We hypothesize that blood pressure (BP), cerebral oxidative stress, inflammation will increase postpartum (PP) ischemic dams. Placental ischemia was induced pregnant Sprague Dawley dams, utilizing reduced uterine perfusion (RUPP) surgery. At 6 weeks PP (~3 human years), BP measured via carotid catheterization, stress were assessed ELISAs, biochemical assays, Western blots. BP, pro-inflammatory cytokines (TNF-α IL-6), GFAP (a marker astrocyte activity) increased RUPP Cerebral hydrogen peroxide (H2O2) also had a strong correlation proinflammatory (TNF- α activation. dams have at postpartum. These changes may contribute pathology development CVDs

Language: Английский

Citations

0
Animal-based approaches to understanding neuroglia physiology in vitro and in vivo DOI
Davide Gobbo, Frank Kirchhoff

Handbook of clinical neurology, Journal Year: 2025, Volume and Issue: unknown, P. 229 - 263

Published: Jan. 1, 2025

Language: Английский

Citations

0
ASTROCYTES AND ALCOHOL THROUGHOUT THE LIFESPAN DOI Creative Commons
Marina Guizzetti, Regina A. Mangieri, Lubov Ezerskiy

et al.

Biological Psychiatry, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Evidence for involvement of astrocytes in several neurodegenerative disorders and drug addiction has been emerging over the last two decades, but only recent years have investigated their roles alcohol use disorder (AUD). As a result, there is need to evaluate existing preclinical literature supporting effects exposure. Here we review evidence about responses alcohol, contributions development AUD. We studies single-cell RNA sequencing with focus on astrocyte heterogeneity, reactivity, role remodeling extracellular matrix. Effects astrocyte-modulated synaptic transmission are also discussed emphasizing never reviewed before. Since play essential brain development, research fetal spectrum (FASD) which may shed light psychiatric that high prevalence individuals affected by FASD. Finally, this highlights gaps knowledge biology further research. Particularly, dire identify subpopulations molecules susceptible exposure be targets therapeutic intervention.

Language: Английский

Citations

0
The link between early-life adversity and later alcohol use disorder: a role for microglia? DOI Creative Commons

H Lichtenstein,

Michelle K. Sequeira, Jessica L. Bolton

et al.

Neurobiology of Stress, Journal Year: 2025, Volume and Issue: unknown, P. 100714 - 100714

Published: Feb. 1, 2025

Language: Английский

Citations

0
Astrocytes in Rodent Anxiety-Related Behavior: Role of Calcium and Beyond DOI Open Access

Marta Gómez‐Gonzalo

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(6), P. 2774 - 2774

Published: March 19, 2025

Anxiety is a physiological, emotional response that anticipates distal threats. When kept under control, anxiety beneficial response, helping animals to maintain heightened attention in environments with potential dangers. However, an overestimation of threats can lead excessive expression that, humans, may evolve into disorders. Pharmacological treatments show variable efficacy among patients, highlighting the need for more efforts better understand pathogenesis Mounting evidence suggests astrocytes, type glial cells, are active partners neurons brain circuits and regulation behaviors both physiological pathological conditions. In this review, I summarize current literature on role astrocytes from different regions modulating anxious states, goal exploring novel cerebral mechanisms identify innovative therapeutic targets treatment

Language: Английский

Citations

0
The functional role of locus coeruleus microglia in the female stress response DOI Creative Commons
Cora E. Smiley, Brittany S. Pate, Samantha J. Bouknight

et al.

Molecular Psychiatry, Journal Year: 2025, Volume and Issue: unknown

Published: April 5, 2025

Abstract Neuropsychiatric disorders that result from stress exposure are highly associated with central inflammation. Our previous work established females selectively exhibit heightened proinflammatory cytokine production within the noradrenergic locus coeruleus (LC) along a hypervigilant behavioral phenotype in response to witnessing social stress. Notably, ablation of microglia using pharmacological techniques prevents this response. These studies were designed further investigate impact stress-induced neuroimmune signaling on long-term and neuronal consequences chemogenetics. We first characterized use an AAV-CD68-G i -DREADD virus targeted LC confirmed viral transduction, selectivity, efficacy. Clozapine-n-oxide (CNO) was used for suppression microglial reactivity during acute chronic vicarious/witness defeat female rats. Chemogenetic-mediated inhibition blunted prevented both responses. Further, history activity typically observed cues. among chemogenetic approach inhibit vivo establish as key driver responses females.

Language: Английский

Citations

0