Chinese Chemical Letters, Journal Year: 2024, Volume and Issue: unknown, P. 110774 - 110774
Published: Dec. 1, 2024
Language: Английский
Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16
Published: Jan. 24, 2025
Polyphenols, naturally occurring phytonutrients found in plant-based foods, have attracted significant attention for their potential therapeutic effects neurological diseases and neuroinflammation. These compounds possess diverse neuroprotective capabilities, including antioxidant, anti-inflammatory, anti-amyloid properties, which contribute to mitigating the progression of neurodegenerative conditions such as Alzheimer's Disease (AD), Parkinson's (PD), Dementia, Multiple Sclerosis (MS), Stroke, Huntington's (HD). Polyphenols been extensively studied ability regulate inflammatory responses by modulating activity pro-inflammatory genes influencing signal transduction pathways, thereby reducing neuroinflammation neuronal death. Additionally, polyphenols shown promise various cellular signaling pathways associated with viability, synaptic plasticity, cognitive function. Epidemiological clinical studies highlight polyphenol-rich diets decrease risk alleviate symptoms disorders Furthermore, demonstrated through regulation key Akt, Nrf2, STAT, MAPK, play critical roles neuroprotection body's immune response. This review emphasizes growing body evidence supporting combating neurodegeneration neuroinflammation, well enhancing brain health. Despite substantial promising hypotheses, further research investigations are necessary fully understand role establish them advanced targets age-related neuroinflammatory conditions.
Language: Английский
Citations
7
World Journal of Psychiatry, Journal Year: 2025, Volume and Issue: 15(3)
Published: Feb. 26, 2025
Diabetes is associated with increased cognitive decline and dementia due to the loss of myelinated nerve fiber function, which linked oligodendrocyte dysfunction. The voltage-gated proton channel 1 (Hv1) important for cellular extrusion machinery. However, its role in regulating diabetes-induced dysfunction unclear. To investigate Hv1 impairment induced by diabetes potential mechanisms, focusing on neuroinflammation, apoptosis, axonal demyelination. A model was established administering a high-fat diet streptozotocin injections mice. knockout (KO) wild-type mice were used evaluate function via behavioral tests neuroinflammation using immunofluorescence. Oligodendrocyte apoptosis assessed terminal deoxynucleotidyl transferase deoxyuridine triphosphate nick-end labeling assay, demyelination analyzed electron microscopy. expression significantly corpus callosum diabetic KO alleviated impairment, reduced decreased inflammatory factors, including interleukin-1 tumor necrosis factor-α, Electron microscopy revealed reduction myelin thickness an g-ratio mice, reversed KO. plays modulating integrity. demonstrates therapeutic mitigating diabetes-related complications.
Language: Английский
Citations
0
Genomics, Journal Year: 2025, Volume and Issue: 117(3), P. 111033 - 111033
Published: March 22, 2025
Language: Английский
Citations
0
Pharmacology Biochemistry and Behavior, Journal Year: 2024, Volume and Issue: 245, P. 173887 - 173887
Published: Oct. 6, 2024
Language: Английский
Citations
3
Published: Aug. 20, 2024
Histamine (HA), a biogenic monoamine, exerts its pleiotropic effects through four H1R–H4R histamine receptors, which are also expressed in brain tissue. Together with the projections of HA-producing neurons located within tuberomammillary nucleus (TMN), innervate most areas brain, they constitute histaminergic system. Thus, while remaining mediator inflammatory reaction and immune system function, HA acts as neurotransmitter modulator other systems central nervous (CNS). Although detailed causes still not fully understood, neuroinflammation seems to play crucial role etiopathogenesis both neurodevelopmental neurodegenerative (neuropsychiatric) diseases, such autism spectrum disorders (ASD), attention-deficit/hyperactivity disorder (ADHD), Alzheimer's disease (AD) Parkinson's (PD). Given increasing prevalence/diagnosis these their socioeconomic impact, need develop effective forms therapy has focused researchers' attention on brain's activity related signaling pathways. This review presents current state knowledge concerning involvement CNS development disorders.
Language: Английский
Citations
1
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(18), P. 9859 - 9859
Published: Sept. 12, 2024
Histamine (HA), a biogenic monoamine, exerts its pleiotropic effects through four H1R–H4R histamine receptors, which are also expressed in brain tissue. Together with the projections of HA-producing neurons located within tuberomammillary nucleus (TMN), innervate most areas brain, they constitute histaminergic system. Thus, while remaining mediator inflammatory reaction and immune system function, HA acts as neurotransmitter modulator other systems central nervous (CNS). Although detailed causes still not fully understood, neuroinflammation seems to play crucial role etiopathogenesis both neurodevelopmental neurodegenerative (neuropsychiatric) diseases, such autism spectrum disorders (ASDs), attention-deficit/hyperactivity disorder (ADHD), Alzheimer’s disease (AD) Parkinson’s (PD). Given increasing prevalence/diagnosis these their socioeconomic impact, need develop effective forms therapy has focused researchers’ attention on brain’s activity related signaling pathways. This review presents current state knowledge concerning involvement CNS development disorders. To this end, roles neurotransmission, neuroinflammation, neurodevelopment discussed.
Language: Английский
Citations
1
Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(10), P. 1293 - 1293
Published: Sept. 28, 2024
Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by social interaction difficulties, repetitive behaviors, and immune dysregulation with elevated pro-inflammatory markers. Autophagic deficiency also contributes to behavior deficits in ASD. Histamine H3 receptor (H3R) antagonism potential treatment strategy for brain disorders features overlapping ASD, such as schizophrenia Alzheimer's disease.
Language: Английский
Citations
1
Redox Report, Journal Year: 2024, Volume and Issue: 29(1)
Published: Nov. 23, 2024
Alzheimer's disease is a neurodegenerative involving memory impairment, confusion, and behavioural changes. The characterised by the accumulation of amyloid beta plaques neurofibrillary tangles in brain, which disrupt normal neuronal function. There no known cure for due to increasing life expectancy, occurrence projected rise over coming decades. causes are multifactorial with inflammation, oxidative stress, genetic epigenetic variation, cerebrovascular abnormalities among strongest contributors. We review current literature surrounding inflammation epigenetics disease, focus on how oxidants from infiltrating immune cells have potential alter DNA methylation profiles ageing brain.
Language: Английский
Citations
1
Chinese Chemical Letters, Journal Year: 2024, Volume and Issue: unknown, P. 110774 - 110774
Published: Dec. 1, 2024
Language: Английский
Citations
0