Non-linear development of brain morphometry in child and adolescent offspring of individuals with bipolar disorder or schizophrenia DOI Creative Commons
Simon R. Poortman, Nikita Setiaman, Marjolein E.A. Barendse

et al.

European Neuropsychopharmacology, Journal Year: 2024, Volume and Issue: 87, P. 56 - 66

Published: July 30, 2024

Offspring of parents with severe mental illness (e.g., bipolar disorder or schizophrenia) are at increased risk developing psychopathology. Structural brain alterations have been found in child and adolescent offspring patients schizophrenia, but the developmental trajectories anatomy this high-familial-risk population still unclear. 300 T1-weighted scans were obtained 187 least one parent diagnosed (n=80) schizophrenia (n=53) without (n=54). The age range was 8 to 23 years old; 113 underwent two scans. Global measures regional cortical thickness surface area computed. A generalized additive mixed model used capture non-linear trajectories. had smaller total volume than (d=-0.20, p=0.004) control (d=-0.22, p=0.005) lower mean (d=-0.23, p<0.001). showed differential cerebral white matter compared (both p's=0.003). Regionally, a significantly different trajectory middle temporal gyrus versus (p<0.001) (p=0.001), which no longer significant after correcting for thickness. These findings suggest that particularly familial high is related reductions deviating global structure measures, not driven by specific regions.

Language: Английский

Beyond sex differences: short- and long-term effects of pregnancy on the brain DOI
Tanvi A. Puri, Jennifer E. Richard, Liisa A.M. Galea

et al.

Trends in Neurosciences, Journal Year: 2023, Volume and Issue: 46(6), P. 459 - 471

Published: April 27, 2023

Language: Английский

Citations

31
Sex is a defining feature of neuroimaging phenotypes in major brain disorders DOI Creative Commons
Lauren E. Salminen, Meral A. Tubi, Joanna K. Bright

et al.

Human Brain Mapping, Journal Year: 2021, Volume and Issue: 43(1), P. 500 - 542

Published: May 5, 2021

Abstract Sex is a biological variable that contributes to individual variability in brain structure and behavior. Neuroimaging studies of population‐based samples have identified normative differences between males females, many which are exacerbated psychiatric neurological conditions. Still, sex MRI outcomes understudied, particularly clinical with known disease risk, prevalence, expression symptoms. Here we review the existing literature on adult 14 distinct disorders. We discuss commonalities sources variance study designs, analysis procedures, subtype effects, impact these factors interpretation. Lastly, identify key problems neuroimaging offer potential recommendations address current barriers optimize rigor reproducibility. In particular, emphasize importance large‐scale initiatives such as Enhancing NeuroImaging Genetics through Meta‐Analyses consortium, UK Biobank, Human Connectome Project, others provide unprecedented power evaluate sex‐specific phenotypes major diseases.

Language: Английский

Citations

48
Sex Differences in Brain and Cognition in de novo Parkinson's Disease DOI Creative Commons
Javier Oltra, Carme Uribe, Anna Campabadal

et al.

Frontiers in Aging Neuroscience, Journal Year: 2022, Volume and Issue: 13

Published: Jan. 6, 2022

Background and Objective: Brain atrophy cognitive impairment in neurodegenerative diseases are influenced by sex. We aimed to investigate sex differences brain cognition de novo Parkinson's disease (PD) patients. Methods: Clinical, neuropsychological T1-weighted MRI data from 205 PD patients (127 males: 78 females) 69 healthy controls (40 29 were obtained the PPMI dataset. Results: males had a greater motor rapid eye movement sleep behavior disorder symptomatology than females. They also showed cortical thinning postcentral precentral regions, global subcortical smaller volumes thalamus, caudate, putamen, pallidum, hippocampus, brainstem, compared with Healthy only reduced hippocampal volume performed worse females cognition, immediate verbal recall, mental processing speed. In both groups semantic fluency delayed recall; as well visuospatial function. Conclusions: Sex effect is already evident not explained age per se, being relevant factor consider clinical translational research PD.

Language: Английский

Citations

32
The Enhancing NeuroImaging Genetics through Meta‐Analysis Consortium: 10 Years of Global Collaborations in Human Brain Mapping DOI Creative Commons
Paul M. Thompson, Neda Jahanshad, Lianne Schmaal

et al.

Human Brain Mapping, Journal Year: 2021, Volume and Issue: 43(1), P. 15 - 22

Published: Oct. 6, 2021

Abstract This Special Issue of Human Brain Mapping is dedicated to a 10‐year anniversary the Enhancing NeuroImaging Genetics through Meta‐Analysis (ENIGMA) Consortium. It reports updates from broad range international neuroimaging projects that pool data around world answer fundamental questions in neuroscience. Since ENIGMA was formed December 2009, initiative grew into worldwide effort with over 2,000 participating scientists 45 countries, and 50 working groups leading large‐scale studies human brain disorders. Over last decade, many lessons were learned on how best diverse sources. Working created develop methods analyze anatomical diffusion magnetic resonance imaging (MRI), resting state task‐based functional MRI, electroencephalography (EEG), magnetoencephalography (MEG), spectroscopy (MRS). The quest understand genetic effects development disease also led analyses scans an unprecedented scale. Genetic roadmaps cortex by researchers who collaborated perform statistically well‐powered common rare variants measures rates aging. Here, we summarize 31 papers this , covering: (a) technical approaches harmonize analysis different types data, (b) reviews decade work several ENIGMA's clinical groups, (c) new empirical reporting mapping patients substance use disorders, schizophrenia, bipolar major depression, posttraumatic stress disorder, obsessive compulsive epilepsy, stroke.

Language: Английский

Citations

36
White matter microstructure shows sex differences in late childhood: Evidence from 6797 children DOI
Katherine E. Lawrence,

Zvart Abaryan,

Emily Laltoo

et al.

Human Brain Mapping, Journal Year: 2022, Volume and Issue: 44(2), P. 535 - 548

Published: Sept. 29, 2022

Sex differences in white matter microstructure have been robustly demonstrated the adult brain using both conventional and advanced diffusion-weighted magnetic resonance imaging approaches. However, sex prior to adulthood remain poorly understood; previous developmental work focused on metrics yielded mixed results. Here, we rigorously characterized among over 6000 children from Adolescent Brain Cognitive Development study who were between 9 10 years old. Microstructure was quantified model-diffusion tensor (DTI)-and an model, restriction spectrum (RSI). DTI included fractional anisotropy (FA) mean, axial, radial diffusivity (MD, AD, RD). RSI normalized isotropic, directional, total intracellular diffusion (N0, ND, NT). We found significant replicable or every region examined across brain. FA regionally specific. Across regions, boys exhibited greater MD, RD than girls, average. Girls displayed increased N0, NT compared boys, average, suggesting cell neurite density girls. Together, these robust findings provide important foundation for understanding health disease.

Language: Английский

Citations

26
The relationship between negative symptoms and MATRICS neurocognitive domains: A meta-analysis and systematic review DOI

Christy Au-Yeung,

Danielle Penney,

Jesse Rae

et al.

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2023, Volume and Issue: 127, P. 110833 - 110833

Published: July 22, 2023

Language: Английский

Citations

13
Lifespan cardiometabolic exposures are associated with midlife white matter microstructure: The Bogalusa Heart Study DOI Creative Commons
Reagan Dugan, Sreekrishna Ramakrishnapillai,

Julia St Amant

et al.

NeuroImage, Journal Year: 2025, Volume and Issue: 307, P. 121034 - 121034

Published: Jan. 17, 2025

Language: Английский

Citations

0
The left amygdala is genetically sexually-dimorphic: multi-omics analysis of structural MRI volumes DOI Creative Commons

Yuanyuan Gui,

Geyu Zhou, Shuya Cui

et al.

Translational Psychiatry, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 22, 2025

Brain anatomy plays a key role in complex behaviors and mental disorders that are sexually divergent. While our understanding of the sex differences brain remains relatively limited, particularly underlying genetic molecular mechanisms contribute to these differences. We performed largest study volumes (N = 33,208) by examining both raw after controlling whole volumes. Genetic correlation analysis revealed only left amygdala. compared transcriptome between males females using data from GTEx characterized cell-type compositions bulk amygdala RNA-seq LIBD single-cell reference profiles. also constructed polygenic risk scores (PRS) investigate sex-specific correlations volume 25,576~105,318) Psychiatric Genomics Consortium other traits UKB 347,996). Although there were pronounced volumes, was no difference heritability sexes. There significant male female identified sex-differentiated effects PRSs for schizophrenia on volume, as well six UKB. found several sex-differentially expressed genes These findings not advanced current knowledge basis anatomy, but presented an important clue future research mechanism targeted treatments.

Language: Английский

Citations

0
Female mice exhibit resistance to disease progression despite early pathology in a transgenic mouse model inoculated with alpha-synuclein fibrils DOI Creative Commons
Stéphanie Tullo,

Janice Park,

Daniel Gallino

et al.

Communications Biology, Journal Year: 2025, Volume and Issue: 8(1)

Published: Feb. 22, 2025

Abstract Despite known sex differences in human synucleinopathies such as Parkinson’s disease, the impact of on alpha-synuclein pathology mouse models has been largely overlooked. To address this need, we examine whole brain signatures neurodegeneration due to aSyn toxicity M83 model using longitudinal magnetic resonance imaging (MRI; T1-weighted; 100 μm 3 isotropic voxel; -7, 30, 90 and 120 days post-injection [dpi]; n ≥ 8 mice/group/sex/time point). initiate spreading, mice are inoculated with recombinant preformed fibrils (Hu-PFF) or phosphate buffered saline right striatum. We observe more aggressive neurodegenerative profiles over time for male Hu-PFF-injected when examining voxel-wise trajectories. However, at dpi, widespread patterns female mice. These not accompanied by any motor symptom onset between sexes. reached their humane endpoint sooner. findings suggest that post-motor onset, despite accelerated disease trajectories mice, may appear sooner (prior symptomatology). sex-specific synucleinopathy phenotypes urgently need be considered improve our understanding neuroprotective mechanisms.

Language: Английский

Citations

0
Developmental trajectories of gyrification and sulcal morphometrics in children and adolescents at high familial risk for bipolar disorder or schizophrenia DOI Creative Commons
Simon R. Poortman,

Jakub Jamarík,

Louise ten Harmsen van der Beek

et al.

Developmental Cognitive Neuroscience, Journal Year: 2025, Volume and Issue: 72, P. 101536 - 101536

Published: Feb. 24, 2025

Offspring of parents with severe mental illness are at increased risk developing psychopathology. Identifying endophenotypic markers in high-familial-risk individuals can aid early detection and inform development prevention strategies. Using generalized additive mixed models, we compared age trajectories gyrification index (GI) sulcal morphometric measures (i.e., depth, length width) between familial for bipolar disorder or schizophrenia controls. 300 T1-weighted MRI scans were obtained 187 (53 % female, range: 8-23 years) (n = 80, n families=55) 53, families=36) controls 54, families=33). 113 underwent two scans. Globally, GI, depth decreased significantly age, width a (near-)linear manner. There no differences groups mean values any the measures. These findings suggest that, on average, young have preserved developmental patterns morphometrics during childhood adolescence.

Language: Английский

Citations

0