Differentiation of claustrum resting‐state functional connectivity in healthy aging, Alzheimer's disease, and Parkinson's disease DOI Creative Commons
Sevilay Ayyıldız, Halil Aziz Velioğlu, Behçet Ayyıldız

et al.

Human Brain Mapping, Journal Year: 2022, Volume and Issue: 44(4), P. 1741 - 1750

Published: Dec. 14, 2022

The claustrum is a sheet-like of telencephalic gray matter structure whose function poorly understood. considered multimodal computing network due to its reciprocal connections with almost all cortical areas as well subcortical structures. Although the has been involved in several neurodegenerative diseases, specific changes remain unclear Alzheimer's disease (AD), and Parkinson's (PD). Resting-state fMRI T1-weighted structural 3D images from healthy elderly (n = 15), AD 16), PD 12) subjects were analyzed. Seed-based FC analysis was performed using CONN toolbox analyzed Computational Anatomy Toolbox for voxel-based morphometry analysis. While we observed decreased between left sensorimotor cortex, auditory association regions associated social cognition compared control group (HC), no significant difference found alterations both comparing HC groups. In group, high cortex related cognitive control, including cingulate gyrus, supramarginal insular demonstrated. addition, results show significantly volume bilateral HC. There differences volumes groups so may offer more precise findings distinguishing PD.

Language: Английский

The Role of the Claustrum in Parkinson’s Disease and Vascular Parkinsonism: A Matter of Network? DOI Creative Commons
Marialuisa Zedde, R. Quatrale,

Gianni Cossu

et al.

Life, Journal Year: 2025, Volume and Issue: 15(2), P. 180 - 180

Published: Jan. 26, 2025

Background: The mechanisms underlying extrapyramidal disorders and their anatomical substrate have been extensively investigated. Recently, the role of claustrum in Parkinson’s disease other neurodegenerative conditions has better detailed. main aim this review was to summarize supporting evidence for degenerative vascular parkinsonism. Methods: anatomy, biology, supply, connections humans were identified described, providing involvement large- small-vessel disease. supply includes up three different sources from a single artery, middle cerebral it is known as territory with an intermediate hemodynamic risk. make sensory integrator relevant point several networks, consciousness movement planning. Conclusions: still incompletely explained structure. However, recent description its multiple indicate that involved diseases, including potential parkinsonism scarce, but might be field warranting future investigations.

Language: Английский

Citations

1
Pathobiology of Cognitive Impairment in Parkinson Disease: Challenges and Outlooks DOI Open Access
K. A. Jellinger

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 25(1), P. 498 - 498

Published: Dec. 29, 2023

Cognitive impairment (CI) is a characteristic non-motor feature of Parkinson disease (PD) that poses severe burden on the patients and caregivers, yet relatively little known about its pathobiology. deficits are evident throughout course PD, with around 25% subtle cognitive decline mild CI (MCI) at time diagnosis up to 83% developing dementia after 20 years. The heterogeneity phenotypes suggests common neuropathological process, characterized by progressive degeneration dopaminergic striatonigral system many other neuronal systems, results not only in structural but also extensive changes functional network activities neurotransmitter dysfunctions. Modern neuroimaging studies revealed multilocular cortical subcortical atrophies alterations intrinsic connectivities. decreased connectivity (FC) default mode (DMN) bilateral prefrontal cortex affected already before development clinical absence changes. Longitudinal associated frontostriatal limbic affections, white matter microlesions between multiple networks, including thalamo-insular, frontoparietal attention cholinergic forebrain noradrenergic system. Superimposed Alzheimer-related (and concomitant) pathologies due interactions α-synuclein, tau-protein β-amyloid contribute pathogenesis both PD Lewy bodies (DLB). To further elucidate interaction pathomechanisms responsible for well-designed longitudinal clinico-pathological warranted supported fluid sophisticated imaging biomarkers as basis better early future disease-modifying therapies.

Language: Английский

Citations

14
Resting State Functional Connectivity of the Marmoset Claustrum DOI Creative Commons

Erin J. Holzscherer,

Alessandro Zanini,

Chun Yin Liu

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: April 29, 2025

Abstract The common marmoset (Callithrix jacchus) has been recently developed as a nonhuman primate model useful for studying behaviour, neurology, and higher-level cognitive processes considering their phylogenetic proximity to humans. Here, we investigated the resting state functional connectivity (RSFC) of claustrum, small, highly connected subcortical structure. Using an open resource 234 MRI scans from awake marmosets, found claustrum prefrontal cortex, posterior parietal temporal cortices, cingulate sensory limbic areas, basal ganglia, cerebellum. We also strong regions hubs involved in networks. These findings demonstrate RSFC similar previous human rodent studies validate integration marmosets into research.

Language: Английский

Citations

0
Dopamine receptor 1 on CaMKII-positive neurons within claustrum mediates adolescent cocaine exposure-induced anxiety-like behaviors and electro-acupuncture therapy DOI Creative Commons
Liying Chen, Zhaoyu Liu, Ziheng Zhao

et al.

Theranostics, Journal Year: 2023, Volume and Issue: 13(10), P. 3149 - 3164

Published: Jan. 1, 2023

Adolescent cocaine exposure (ACE) increases risk of developing psychiatric problems such as anxiety, which may drive relapse in later life, however, its underlying molecular mechanism remains poorly understood.Methods: ACE male mice model were established by exposing to during adolescent period.Elevated plus maze (EPM) used assess anxiety-like behaviors mice.Within claustrum, local injection SCH-23390, a specific antagonist for dopamine receptor 1 (D1R), or D1R knocking-down virus regulate function expression on CaMKII-positive neurons (D1R CaMKII ) vivo.Electro-acupuncture (EA) treatment was performed at acupoints Baihui and Yintang withdrawal period.Results: We found that exhibited behaviors, along with more activated increased levels claustrum adulthood.Inhibiting efficiently reduced activation, ultimately suppressed adulthood.EA alleviated ACE-evoked activation suppressing .Conclusion: Our findings identified novel role ACE-induced put new insight into the claustrum.The might be promising pharmacological target, EA treatment, treat drug-induced behaviors.

Language: Английский

Citations

6
Association of polygenic risk for bipolar disorder with resting-state network functional connectivity in youth with and without bipolar disorder DOI
Xinyue Jiang, Clement C. Zai, Alysha A. Sultan

et al.

European Neuropsychopharmacology, Journal Year: 2023, Volume and Issue: 77, P. 38 - 52

Published: Sept. 15, 2023

Language: Английский

Citations

5
Differentiation of claustrum resting‐state functional connectivity in healthy aging, Alzheimer's disease, and Parkinson's disease DOI Creative Commons
Sevilay Ayyıldız, Halil Aziz Velioğlu, Behçet Ayyıldız

et al.

Human Brain Mapping, Journal Year: 2022, Volume and Issue: 44(4), P. 1741 - 1750

Published: Dec. 14, 2022

The claustrum is a sheet-like of telencephalic gray matter structure whose function poorly understood. considered multimodal computing network due to its reciprocal connections with almost all cortical areas as well subcortical structures. Although the has been involved in several neurodegenerative diseases, specific changes remain unclear Alzheimer's disease (AD), and Parkinson's (PD). Resting-state fMRI T1-weighted structural 3D images from healthy elderly (n = 15), AD 16), PD 12) subjects were analyzed. Seed-based FC analysis was performed using CONN toolbox analyzed Computational Anatomy Toolbox for voxel-based morphometry analysis. While we observed decreased between left sensorimotor cortex, auditory association regions associated social cognition compared control group (HC), no significant difference found alterations both comparing HC groups. In group, high cortex related cognitive control, including cingulate gyrus, supramarginal insular demonstrated. addition, results show significantly volume bilateral HC. There differences volumes groups so may offer more precise findings distinguishing PD.

Language: Английский

Citations

6