New-onset hematologic disorders following COVID-19 vaccination: a systematic review DOI Creative Commons
Nelson Luis Cahuapaza-Gutierrez, Cielo Cinthya Calderon-Hernandez, Renzo Pajuelo-Vásquez

et al.

Clinical and Experimental Vaccine Research, Journal Year: 2025, Volume and Issue: 14

Published: Jan. 1, 2025

Coronavirus disease 2019 (COVID-19) vaccination reduced morbimortality rates due to severe acute respiratory syndrome coronavirus 2 infection worldwide. However, various complications have been reported, including hematologic disorders. We conducted a systematic review synthesize and analyze the current available evidence on development of hematological disorders associated with COVID-19 vaccination. A total 227 patients were reported in papers that selected be included. There was slight predominance females (n=114, 50.22%) compared males (n=113, 49.78%), calculated mean age 54.86±18.94 years. The most frequently Immune thrombocytopenic purpura (n=58, 25.55%), followed by thrombotic (n=38, 16.74%). less recorded cases acquired factor XIII/13 deficiency (n=2, 0.88%) pernicious anemia 0.88%). Messenger RNA (mRNA)-based vaccines, Pfizer BioNTech 162b2 (n=106, 46.70%), Moderna mRNA 127-3 (n = 42, 18.50%), Bivalent vaccine 1, 0.44%), prevalent (n=150, 66.08%). Most developed after first dose (n=120, 52.86%). In cases, patient outcomes favorable (n=175, 77.09%), but there significant mortality (n=23, 10.13%). Our findings suggest close monitoring who receive technology regardless sex, especially adults, as they appear more vulnerable developing PROSPERO Identifier: CRD42023452589.

Language: Английский

Ultrasensitive DNA Origami Plasmon Sensor for Accurate Detection in Circulating Tumor DNAs DOI
Zhi Chen,

Changle Meng,

Xueliang Wang

et al.

Laser & Photonics Review, Journal Year: 2024, Volume and Issue: 18(10)

Published: May 1, 2024

Abstract Early lung cancer screening by computed tomography is hampered pulmonary nodules caused massive COVID‐19 infections, necessitating an ultrasensitive approach for the early diagnosis of cancers at single‐base level from circular tumor DNAs (ctDNAs). This study introduces that merges DNA origami and scissors technologies in a framework surface plasmon resonance (SPR) biosensors. By combining precision probes with inherent resolution scissors, this method systematically addresses limitations conventional SPR techniques, resulting enhanced detection accuracy. The synergistic interplay between enables biosensors to achieve unprecedented levels sensitivity, precision, practical utility. efficacy allows precise identification mutations, demonstrated here T790M mutation EGFR gene G12C KRAS non‐small cell patients. With technique, as well near zeptomolar‐level sensitivity achieved. As result, discovery holds significant potential advance field diagnostics.

Language: Английский

Citations

68
The WHO has declared the end of pandemic phase of COVID‐19: Way to come back in the normal life DOI Creative Commons
Rapty Sarker, A. S. M. Roknuzzaman,

Nazmunnahar Nazmunnahar

et al.

Health Science Reports, Journal Year: 2023, Volume and Issue: 6(9)

Published: Sept. 1, 2023

The coronavirus disease 2019 (COVID-19) pandemic has resulted in significant global mortality and morbidity affecting millions of lives. As healthcare authorities worldwide are still paying substantial attention to COVID-19, other diseases continue cause more deaths than COVID-19. decreasing number COVID-19 cases indicates that the is close end. For effective management, facilities have established units testing facilities, instituting infection prevention control measures, employing telehealth services. Healthcare professionals identified some promising treatments for COVID-19; also, mass vaccinations improved patient outcomes. Instead as a pandemic, it time pay lessen their impact on public health. Therefore, World Health Organization (WHO) declared end phase considering current situation our preparedness, past experience, long social economic life May 5, 2023. In this article, we briefly discussed present challenges due necessary precautions, future directions return before

Language: Английский

Citations

56
Historical evolution of healthcare systems of post-soviet Russia, Belarus, Kazakhstan, Kyrgyzstan, Tajikistan, Turkmenistan, Uzbekistan, Armenia, and Azerbaijan: A scoping review DOI Creative Commons
Yuliya Semenova, Lisa Lim, Zhandos Salpynov

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(8), P. e29550 - e29550

Published: April 1, 2024

This scoping review addresses the transformation and development of new healthcare systems in nine countries -Armenia, Azerbaijan, Belarus, Kazakhstan, Kyrgyzstan, Russia, Tajikistan, Turkmenistan, Uzbekistan over period following collapse Soviet Union from 1991 to present. assessment focuses on maternal child health, mental communicable diseases, non-communicable diseases an effort highlight changes status these under scrutiny. Considering that all post-Soviet nations are officially recognized members World Health Organization (WHO) have demonstrated their commitment attaining WHO's objectives, evaluation system progress improvement was carried out utilizing indicators provided by WHO. reveals evolution could be considered sustainable, given average life expectancy has returned level it 1991- year USSR's breakup, people's health improved since turn twenty-first century. To enhance potential success future reforms, however, governments must monitor implementation reform process, evaluate achievement make necessary adjustments. The will depend active involvement government, medical community, patient as well obtaining support local authorities. study may help identify successful failed strategies, guiding investments.

Language: Английский

Citations

22
The WHO has Declared COVID-19 is No Longer a Pandemic-Level Threat: A Perspective Evaluating Potential Public Health Impacts DOI Creative Commons
A. S. M. Roknuzzaman, Rapty Sarker,

Nazmunnahar Nazmunnahar

et al.

Clinical Pathology, Journal Year: 2024, Volume and Issue: 17

Published: Jan. 1, 2024

Language: Английский

Citations

11
Next-generation treatments: Immunotherapy and advanced therapies for COVID-19 DOI Creative Commons

Jenny Andrea Arévalo-Romero,

Sandra M. Chingaté-López,

Bernardo Camacho

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(5), P. e26423 - e26423

Published: Feb. 19, 2024

The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged in 2019 following prior outbreaks of coronaviruses like SARS and MERS recent decades, underscoring their high potential infectivity humans. Insights from previous have played a significant role developing effective strategies to mitigate the global impact SARS-CoV-2. As January 7, 2024, there been 774,075,242 confirmed cases worldwide. To date, 13.59 billion vaccine doses administered, 7,012,986 documented fatalities (https://www.who.int/)Despite progress addressing rapid evolution SARS-CoV-2 challenges human defenses, presenting ongoing challenges. emergence new lineages, shaped mutation recombination processes, has led successive waves infections. This scenario reveals need for next-generation vaccines as crucial requirement ensuring protection against demand calls formulations that trigger robust adaptive immune response without leading inflammation linked with infection.Key mutations detected Spike protein, critical target neutralizing antibodies design —specifically within Receptor Binding Domain region Omicron variant lineages (B.1.1.529), currently dominant worldwide, intensified concerns due association immunity evasion vaccinations infections.As world deals this evolving threat, narrative extends realm emerging variants, each displaying implications remain largely misunderstood. Notably, JN.1 lineage is gaining prevalence, early findings suggest it stands among immune-evading characteristic attributed its L455S. Moreover, detrimental consequences novel bear particularly on immunocompromised individuals older adults. Immunocompromised face such suboptimal responses vaccines, rendering them more susceptible disease. Similarly, adults an increased risk disease presence comorbid conditions, find themselves at heightened vulnerability develop Thus, recognizing these intricate factors effectively tailoring public health protect vulnerable populations. In context, review aims describe, analyze, discuss current treatments encompassing immunotherapeutic approaches advanced therapies complements will offer solutions counter disadvantages existing options. Preliminary outcomes show virus address immunomodulatory associated COVID-19. Furthermore, capacity promote tissue repair demonstrated, which can be noteworthy who stand actors landscape possess broader potential, offering wide range variants enhancing ability constant virus. are projected treatment alternatives managing Chronic Post-COVID-19 syndromeand long-term complications.

Language: Английский

Citations

10
Unleashing inkjet-printed nanostructured electrodes and battery-free potentiostat for the DNA-based multiplexed detection of SARS-CoV-2 genes DOI Creative Commons
Marianna Rossetti, Chawin Srisomwat, Massimo Urban

et al.

Biosensors and Bioelectronics, Journal Year: 2024, Volume and Issue: 250, P. 116079 - 116079

Published: Jan. 28, 2024

Following the global COVID-19 pandemic triggered by SARS-CoV-2, need for rapid, specific and cost-effective point-of-care diagnostic solutions remains paramount. Even though is no longer a public health emergency, disease still poses threat leading to deaths, it continues change with risk of new variants emerging causing surge in cases deaths. Here, we address urgent SARS-CoV-2. We propose multiplexed DNA-based sensing platform that utilizes inkjet-printed nanostructured gold electrodes an battery-free near-field communication (NFC) potentiostat simultaneous quantitative detection two SARS-CoV-2 genes, ORF1ab N gene. The strategy based on formation RNA-DNA sandwich structure leads highly electrochemical output. providing large surface area enable efficient binding increase sensitivity. NFC enables rapid measurements real-time data analysis via smartphone application, making accessible portable. With advantages speed (5 min), simplicity, sensitivity (low pM range, ∼450% signal gain) cost-effectiveness, proposed promising alternative diagnostics high-throughput complements toolkit.

Language: Английский

Citations

7
Current landscape of long COVID clinical trials DOI
Manojit Bhattacharya, Srijan Chatterjee,

Sanskriti Saxena

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 132, P. 111930 - 111930

Published: March 27, 2024

Language: Английский

Citations

6
Centenarians, semi and supercentenarians, COVID-19 and Spanish flu: a serological assessment to gain insight into the resilience of older centenarians to COVID-19 DOI Creative Commons
Claudia Maria Trombetta, Giulia Accardi, Anna Aiello

et al.

Immunity & Ageing, Journal Year: 2024, Volume and Issue: 21(1)

Published: June 27, 2024

Although it is well known that the older people have been most susceptible to COVID-19, there are conflicting data on susceptibility of centenarians. Two epidemiological study shown centenarians (> 101 years old at time 2020 pandemic peak) more resilient than remaining centenarians, suggesting this resilience might be linked 1918 Spanish Flu pandemic. To gain insight into matter, specifically whether SARS-CoV-2 infection they had affected by, we conducted a retrospective serological study. This examined serum samples from 33 encompassing semi- (aged > 104 < 110 years, N = 7) and supercentenarians 109 4), born between 1905 1922, against both H1N1 pseudotype virus.

Language: Английский

Citations

5
Access to healthcare services during the COVID-19 pandemic: a cross-sectional analysis of income and user-access across 16 economically diverse countries DOI Creative Commons

Zachary D V Abel,

Laurence S. J. Roope, Raymond Duch

et al.

BMC Public Health, Journal Year: 2024, Volume and Issue: 24(1)

Published: Oct. 1, 2024

Language: Английский

Citations

4
A cohort-based assessment of drug use trends during the COVID-19 pandemic: relationship with mood and sociodemographic factors in Brazil DOI Creative Commons
Núbia Heidrich, Maurício Schüler Nin, Felipe Borges Almeida

et al.

Frontiers in Psychiatry, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 30, 2025

The COVID-19 pandemic has brought significant challenges, including severe psychological consequences, especially for vulnerable individuals, such as those with substance use disorders. This study investigated the impact of on patterns and health in Brazilians, exploring associations sociodemographic factors to identify groups at higher risk. Data were collected online assess self-reported through Alcohol, Smoking Substance Involvement Screening Test (ASSIST), state, using Depression, Anxiety Stress Scale (DASS-21) level social distancing. research was conducted three waves: September-October 2020, April-May 2021, September-November 2022. ASSIST (alcohol, cannabis, hallucinogens, cocaine/crack) DASS-21 (anxiety, depression, stress) scores decreased over time. Regarding data, being male, single, less education, lower income distancing showed alcohol cannabis scores. All drug symptoms time, suggesting a possible adaptation or resilience sample challenges pandemic. These findings highlight importance monitoring mental times crisis, populations. Such knowledge is essential inform public strategies prepare systems face future global crises.

Language: Английский

Citations

0