The Impact of Estrogen Deficiency Symptoms on Health-Related Quality of Life in Menopausal-Aged Women in China

IntechOpen eBooks, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 13, 2025

Menopausal symptoms are a critical health issue as they can have substantial detrimental effect on women’s physical and mental substantially impair health-related quality of life (HRQoL). Vasomotor (VMS) such hot flushes, sweating, sleep disturbances, irritability, anxiety, depression often considered the cardinal menopause. Among Chinese women menopausal age, symptom burden is high, with flushes/sweating, disorders, mood fatigue reported to be prevalent. In this chapter, we describe available data across pre-, peri-, post-menopausal phases among impact these HRQoL. We provide an overview recommendation for estrogen-based hormone therapy treatment estrogen deficiency symptoms, given in combination progestogen non-hysterectomized women. also benefits estradiol plus dydrogesterone postmenopausal ethnicity, which include consistent improvements frequency severity Finally, highlight importance timely identification management need increase awareness population.

Language: Английский

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State of the art in menopause: current best practice approaches from the IMS World Congress 2024, Melbourne

Climacteric, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 6

Published: Feb. 10, 2025

The 19th World Congress on Menopause, hosted by the International Menopause Society in 2024, convened global experts to discuss latest advances menopause management. This review highlights key focus areas presented at congress, offering insights into best practices for clinical application. Cardiovascular health remains a priority, with emphasis recognizing sex-specific risk factors and exploring emerging therapies. Osteoporosis management underscores role of menopausal hormone therapy (MHT) as foundational, complemented anti-resorptive bone-forming agents high-risk populations those not candidates MHT. Addressing genitourinary symptoms sexual health, vaginal estrogen is confirmed safe effective option dehydroepiandrosterone (DHEA) oral ospemifene suitable alternatives, while testosterone offers benefits hypoactive desire disorder postmenopausal women. Sleep disturbances, depression workplace challenges linked were explored, tailored interventions such MHT cognitive behavioral specifically sleep recommended. Cancer stressed need multidisciplinary approach reduction beginning lifestyle modification, non-hormonal therapies prioritized symptomatic treatment hormone-sensitive cancers. Lastly, perimenopause highlighted comprehensive approaches integrating symptom relief contraceptive needs.

Language: Английский

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Polysaccharides from traditional Chinese medicine and their nano-formulated delivery systems for cancer immunotherapy

Carbohydrate Polymers, Journal Year: 2025, Volume and Issue: 357, P. 123416 - 123416

Published: Feb. 20, 2025

Language: Английский

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Changes in menopause-specific quality of life between women with transdermal estradiol versus oral estrogens: results of a randomized controlled trial

Gynecological Endocrinology, Journal Year: 2025, Volume and Issue: 41(1)

Published: April 1, 2025

To compare the efficacy of oral and transdermal estrogens in improving quality life perimenopausal recently postmenopausal women. 257 women aged 40-55 years, within three years after their final menstrual period were randomized to receive oestrogel (t-E2) (n = 128) or estradiol valerate (o- E2V) 129; both with micronized progesterone 200 mg for 14 days each month). Menopausal symptoms recorded at screening 4, 12, 24 weeks post-randomization. evaluated using Menopause-Specific Quality Life (MENQOL) questionnaire. Significant improvements MENQOL scores observed groups compared baseline. The decrease treatment showed almost no difference between two (p > 0.05) except VMS domain which indicated a better result estrogen group weeks. This study that highly effective relieving overall menopausal recently-menopausal women, little routes.

Language: Английский

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Quality of life at peri- and postmenopause: analysis of the results from app “Mi Menopausia”

Maturitas, Journal Year: 2025, Volume and Issue: 197, P. 108267 - 108267

Published: April 19, 2025

To assess the health-related quality of life (HRQOL) Spanish peri- and postmenopausal women using Cervantes Short Form (SF) scale, factors associated with its variations. A total 7103 were registered app "Mi Menopausia" from June 2021 to 2024. This is designed specifically for women. It measures HRQOL SF scale (higher scores indicate lower HRQOL). Data collected included demographic information, lifestyle details, menopause symptoms, treatments symptom relief, personal medical history. Of 6833 in final analysis, 47.9 % 52.1 postmenopausal. The overall score was 40.1 ± 16.8 multivariant analysis age (B: -0.29, 95 confidence interval (CI): -0.36 -0.21), obesity 1.68; 95CI: 0.44 2.93), status 1.11; 0.22 2.0), education level -1.05; -1.91 -0.19), having a partner -2.76; -4.03 -1.49), sexual intercourse -8.25; -9.81 -6.69), no activity 5.86; 3.91 7.81), diagnosis depression 8.34; 7.34 9.35), undergone hysterectomy 0.51; 0.10 3.64) oophorectomy 0.90; experienced bone fractures 0.71; 0.12 2.90). complex but improvable various factors, particularly related or anxiety.

Language: Английский

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Ultra-low-dose estradiol and dydrogesterone for the treatment of menopausal symptoms in a pooled, multi-ethnic population

Maturitas, Journal Year: 2024, Volume and Issue: 190, P. 108117 - 108117

Published: Sept. 17, 2024

Language: Английский

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A terapia de reposição hormonal bioidêntica na menopausa: aplicabilidade e evoluções

Brazilian Journal of Health Review, Journal Year: 2024, Volume and Issue: 7(3), P. e69486 - e69486

Published: May 7, 2024

Introdução: a menopausa é uma fase natural na vida de mulher, marcada pela cessação da menstruação e série mudanças hormonais que podem resultar em sintomas desconfortáveis impactar significativamente qualidade vida. Objetivo: investigar aplicabilidade as evoluções terapia reposição hormonal bioidêntica menopausa. Metodologia: trata-se revisão integrativa literatura. Adotou-se como pergunta norteadora: "Como está sendo aplicada gestão dos quais são últimas descobertas nesta área?" Para construção pesquisa, coleta análise dados foi realizada através do Medical Literature Analysis and Retrieval System Online, Biblioteca Virtual Saúde (BVS) Google Acadêmico seguintes Descritores Ciências (DeCS): “Menopausa”; “Terapia Reposição Hormonal”, “Estrogênios” combinados entre si pelo operador booleano AND com seus respectivos correspondentes no Mesh Terms. Resultados Discussão: após o cumprimento procedimentos metodológicos, 12 artigos disponíveis Portal BVS, base PubMed foram selecionados, os retratam apesar interesse crescente, ainda há questões aberto sobre eficácia segurança dessas terapias. Alguns estudos sugerem pode ser tão eficaz quanto convencional redução Considerações Finais: representa área grande potencial promoção saúde das mulheres nessa

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Low-dose and ultra-low-dose estradiol and dydrogesterone in postmenopause: an analysis by body mass index

Climacteric, Journal Year: 2024, Volume and Issue: 28(1), P. 21 - 27

Published: Oct. 30, 2024

Objective Oral, low-dose and ultra-low-dose continuous combined 17β-estradiol (E) plus dydrogesterone (D) reduce vasomotor symptoms (VMS) in postmenopausal women.

Language: Английский

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A quality assessment and systematic review of clinical practice guidelines on hormone replacement therapy for menopause using the AGREE II instrument

European Journal of Obstetrics & Gynecology and Reproductive Biology, Journal Year: 2024, Volume and Issue: 303, P. 294 - 301

Published: Nov. 2, 2024

Language: Английский

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