A Photoactivated Self‐Assembled Nanoreactor for Inducing Cascade‐Amplified Oxidative Stress toward Type I Photodynamic Therapy in Hypoxic Tumors

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 5, 2024

Abstract Type I photodynamic therapy (PDT) generates reactive oxygen species (ROS) through oxygen‐independent photoreactions, making it a promising method for treating hypoxic tumors. However, the superoxide anion (O 2 ∙ – ) generated usually exhibits low oxidation capacity, restricting antitumor efficacy of PDT in clinical practice. Herein, photoactivated self‐assembled nanoreactor ( 1 ‐NBS@CeO is designed integration type and cerium oxide (CeO nanozymes inducing cascade‐amplified oxidative stress The constructed though co‐assembly an amphiphilic peptide ‐NBS) CeO , giving well‐dispersed spherical nanoparticles with enhanced dismutase (SOD)‐like peroxidase (POD)‐like activities. Following light irradiation, undergoes photoreactions to O which further catalyzed by nanoreactors, ultimately forming hypertoxic hydroxyl radical (∙OH) reactions. treatment using results elevation intracellular ROS depletion GSH content A375 cells, thereby mitochondrial dysfunction triggering apoptosis ferroptosis tumor cells. Importantly, intravenous administration alongside irradiation showcases enhances satisfactory biocompatibility vivo. Together, facilitates achieving efficacious PDT, holds great promise developing therapeutic modules towards

Language: Английский

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Acid‐Triggered Cascaded Responsive Supramolecular Peptide Alleviates Myocardial Ischemia‒Reperfusion Injury by Restoring Redox Homeostasis and Protecting Mitochondrial Function

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 20, 2025

Abstract Redox imbalance, including excessive production of reactive oxygen species (ROS) caused by mitochondrial dysfunction and insufficient endogenous antioxidant capacity, is the primary cause myocardial ischemia‒reperfusion (I/R) injury. In exploration reducing I/R injury, it found that protecting function after reperfusion not only reduces ROS bursts but also inhibits cell apoptosis triggered release cytochrome c. Additionally, nuclear factor erythroid 2‐related 2 (Nrf2) considered a potential therapeutic target for treating injury enhancing cellular capacity through induction enzymes. this study, peptide‒drug conjugate OI‐FFG‐ss‐SS31(ISP) developed integrating Nrf2 activator 4‐octyl itaconate (OI) mitochondria‐targeting protective peptide elamipretide (SS31), its explored. The results showed ISP could self‐assemble into nanofibers in response to acidic microenvironment bind Keap‐1 with high affinity, thereby activating capacity. Simultaneously, SS31 improve reduce ROS, ultimately providing restoration redox homeostasis effectively alleviate This study presents promising acid‐triggered peptide‐drug

Language: Английский

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A computer-aided, carrier-free drug delivery system with enhanced cytotoxicity and biocompatibility: a universal model for multifunctional lung cancer therapy

Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: 250, P. 114557 - 114557

Published: Feb. 9, 2025

Language: Английский

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Nanomaterials for acute myeloid leukemia therapy: Current progress and future perspectives

Deleted Journal, Journal Year: 2025, Volume and Issue: unknown

Published: March 21, 2025

Abstract Acute myeloid leukemia (AML) is a highly aggressive hematologic malignancy characterized by poor prognosis, high relapse rates, and resistance to conventional chemotherapy. The limitations of standard treatments, including systemic toxicity non‐specific drug distribution, highlight the need for novel therapeutic strategies. Nanoparticles (NPs) represent promising approach enhancing AML treatment improving solubility, bioavailability, targeted delivery while simultaneously minimizing adverse effects. Various NPs, liposomes, polymeric micelles, dendrimers, carbon‐based, metal have been explored their ability selectively target leukemic cells through passive active targeting mechanisms. Functionalized NPs can exploit enhanced permeability retention effect accumulation in leukemia‐affected tissues, ligand‐modified enable AML‐specific biomarkers such as CD33, CD123, folate receptors. Furthermore, facilitate combination therapies, controlled release, intracellular delivery, overcoming multidrug efficacy. This review discusses latest advancements NP‐based strategies, prospects clinical translation, emphasizing potential nanotechnology revolutionizing treatment.

Language: Английский

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An injectable multifunctional nanocomposite hydrogel promotes vascularized bone regeneration by regulating macrophages

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: April 7, 2025

Language: Английский

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