Bioconjugate Chemistry,
Journal Year:
2024,
Volume and Issue:
35(7), P. 1015 - 1023
Published: June 21, 2024
Currently,
clinical
therapeutic
strategies
for
nasopharyngeal
carcinoma
(NPC)
confront
insurmountable
dilemmas
in
which
surgical
resection
is
incomplete
and
chemotherapy/radiotherapy
has
significant
side
effects.
Phototherapy
offers
a
maneuverable,
effective,
noninvasive
pattern
NPC
therapy.
Herein,
we
developed
lysosome-targeted
pH-responsive
nanophototheranostic
near-infrared
II
(NIR-II)
fluorescence
imaging-guided
photodynamic
therapy
(PDT)
photothermal
(PTT)
of
NPC.
A
S-D-A-D-S-type
NIR-II
phototheranostic
molecule
(IRFEM)
encapsulated
within
the
acid-sensitive
amphiphilic
DSPE-Hyd-PEG2k
to
form
IRFEM@DHP
nanoparticles
(NPs).
The
prepared
exhibits
good
accumulation
acidic
lysosomes
facilitating
release
IRFEM,
could
disrupt
lysosomal
function
by
generating
an
amount
heat
ROS
under
laser
irradiation.
Moreover,
guidelines
enhance
accuracy
PTT/PDT
avoid
damage
normal
tissues.
Remarkably,
enable
efficient
antitumor
effects
both
Current Opinion in Chemical Biology,
Journal Year:
2024,
Volume and Issue:
81, P. 102497 - 102497
Published: July 5, 2024
The
recent
approval
of
Akalux®
for
antibody-targeted
photodynamic
therapy
(PDT)
in
Japan
(also
known
as
photoimmunotherapy),
and
the
Cytalux®
folate-specific
image
guided
surgery
by
FDA
have
motivated
continued
development
macromolecular
targeted
PDT
cancer
management.
This
review
spotlights
some
most
advances
since
2021,
exploring
latest
protein
engineering,
adaptive
constructs
nanotechnology,
adoption
immune
checkpoint
inhibitors,
targeting
using
biomimetic
membranes.
These
strategies
summarized
here
attempt
to
expand
functionality,
benefit,
success
advance
technology
beyond
what
has
already
entered
into
clinical
realm.
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(32), P. 21009 - 21023
Published: Aug. 1, 2024
Acute
lung
injury
(ALI)
and
its
severe
form,
acute
respiratory
distress
syndrome
(ARDS),
induce
high
morbidity
mortality
rates,
which
challenge
the
present
approaches
for
treatment
of
ALI/ARDS.
The
clinically
used
photosensitizer
verteporfin
(VER)
exhibits
great
potential
in
(ALI/ARDS)
by
regulating
macrophage
polarization
reducing
inflammation.
Nevertheless,
hydrophobic
characteristics,
nonspecificity,
constrained
bioavailability
hinder
therapeutic
efficacy.
In
this
work,
we
developed
a
type
VER-cored
artificial
exosome
(EVM),
was
produced
using
mesoporous
silica
nanoparticles
(MSNs)
to
load
VER,
followed
exocytosis
internalized
VER-MSNs
from
mouse
bone
marrow-derived
mesenchymal
stem
cells
(mBMSCs)
without
further
modification.
Both
vitro
vivo
assessments
confirmed
powerful
anti-inflammation
induced
EVM.
EVM
also
showed
significant
higher
accumulation
inflammatory
lungs
compared
with
healthy
ones,
beneficial
improved
pulmonary
function,
attenuated
injury,
reduced
ALI
mice
levels
biocompatibility,
exhibiting
5-fold
survival
rate
than
control.
This
emitted
near-infrared
light
presence
laser
activation,
endowed
trackable
ability
both
vivo.
Our
work
photosensitizer-loaded
membrane
integrity
traceability.
To
best
our
knowledge,
kind
intracellularly
synthesized
ALI/ARDS
therapy.
Advanced Healthcare Materials,
Journal Year:
2023,
Volume and Issue:
13(11)
Published: Dec. 20, 2023
Photodynamic
therapy
(PDT)
with
aggregation-induced
emission
(AIE)
photosensitizers
(PSs)
is
a
promising
therapeutic
strategy
to
achieve
better
anticancer
results.
However,
eradicating
solid
tumors
completely
by
PDT
alone
can
be
difficult
owing
the
inherent
drawbacks
of
this
treatment,
and
combination
other
modalities
provides
opportunities
cooperative
enhancement
interactions
among
various
treatments.
Herein,
work
presents
construction
biocompatible
nanocomposite,
namely
CaO
Bioconjugate Chemistry,
Journal Year:
2024,
Volume and Issue:
35(7), P. 1015 - 1023
Published: June 21, 2024
Currently,
clinical
therapeutic
strategies
for
nasopharyngeal
carcinoma
(NPC)
confront
insurmountable
dilemmas
in
which
surgical
resection
is
incomplete
and
chemotherapy/radiotherapy
has
significant
side
effects.
Phototherapy
offers
a
maneuverable,
effective,
noninvasive
pattern
NPC
therapy.
Herein,
we
developed
lysosome-targeted
pH-responsive
nanophototheranostic
near-infrared
II
(NIR-II)
fluorescence
imaging-guided
photodynamic
therapy
(PDT)
photothermal
(PTT)
of
NPC.
A
S-D-A-D-S-type
NIR-II
phototheranostic
molecule
(IRFEM)
encapsulated
within
the
acid-sensitive
amphiphilic
DSPE-Hyd-PEG2k
to
form
IRFEM@DHP
nanoparticles
(NPs).
The
prepared
exhibits
good
accumulation
acidic
lysosomes
facilitating
release
IRFEM,
could
disrupt
lysosomal
function
by
generating
an
amount
heat
ROS
under
laser
irradiation.
Moreover,
guidelines
enhance
accuracy
PTT/PDT
avoid
damage
normal
tissues.
Remarkably,
enable
efficient
antitumor
effects
both
