Acta Diabetologica, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 21, 2024
Language: Английский
Advanced Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 9, 2025
Despite advancements in biomimetic mineralization techniques, the repair of large-scale bone defects remains a significant challenge. Inspired by formation process, multidimensional cascade strategy is developed replicating biomineralization cascade, emulating hierarchical structure bone, and biomimicking its biological functions for efficient regeneration. This involves photocrosslinking sodium methacrylate carboxymethyl cellulose-stabilized amorphous magnesium-calcium phosphate with methacrylate-modified type I collagen to create self-mineralizing hydrogel. The hydrogel then integrated either naturally derived or synthetic oriented bulk scaffolds. resulting composite, named Osteomimix, provides excellent mechanical support can be customized irregular using CAD/CAM technology. Through vitro vivo studies, this work finds that Osteomimix exhibits spontaneous situ cell-free environment, while modulating immune responses promoting vascularized cell-dependent manner. Built on bone-specific insights, achieves biomimicry across temporal, spatial, functional dimensions, facilitating seamless integration artificial constructs natural tissue dynamics.
Language: Английский
Citations
2
npj Biofilms and Microbiomes, Journal Year: 2024, Volume and Issue: 10(1)
Published: July 13, 2024
Dental calculus severely affects the oral health of humans and animal pets. Calculus deposition gingival appearance causes inflammation. Failure to remove dental from dentition results in diseases such as periodontitis. Apart adversely affecting health, some systemic are closely related deposition. Hence, identifying mechanisms formation helps protect health. A plethora biological physicochemical factors contribute physiological equilibrium cavity. Bacteria an important part equation. commences when bacterial is broken. accumulate locally form biofilms on tooth surface. The bacteria promote increases local calcium phosphorus concentrations, which triggers biomineralization development calculus. Current treatments only help relieve symptoms caused by These prone relapse if removal not under control. There a need for treatment regime that combines short-term long-term goals addressing formation. present review introduces formation, influencing factors, relationship between several diseases. This followed presentation conceptual solution improving existing strategies minimizing recurrence.
Language: Английский
Citations
8
Deleted Journal, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 20, 2025
Abstract The field of extracellular vesicle (EV) research has rapidly evolved, revealing their significant roles in various biological processes and clinical applications. Allergic diseases are prevalent immunological disorders characterized by exaggerated hypersensitivity reactions to allergens, leading diverse manifestations that can severely impact quality life. Recently, studies have underscored the pivotal role EVs allergic conditions, including asthma, rhinitis, atopic dermatitis. In this review, we provide a comprehensive overview recent advances separation characterization EVs, diseases, diagnostic value as biomarkers. Additionally, explore therapeutic potential for treatment prevention conditions. Overall, emerging insights into present promising opportunities enhancing diagnosis, treatment, management diseases.
Language: Английский
Citations
1
Oral Diseases, Journal Year: 2024, Volume and Issue: unknown
Published: July 26, 2024
Abstract Objectives This study investigated the role of fibrin on neutrophil extracellular traps (NETs) formation from neutrophils and to elucidate involvement mitochondria in NETs during periodontitis. Materials Methods Plasminogen‐deficient ( Plg −/− ) mice were employed evaluate effects deposition inflammation, bone resorption, infiltration periodontal tissues. In addition, vitro tests evaluated fibrin's impact neutrophil‐driven inflammation. Mitochondrial reactive oxygen species (mtROS) levels within quantified utilizing flow cytometry immunofluorescence vitro. Furthermore, anti‐inflammatory properties mtROS scavenger, Mito‐TEMPO, confirmed regulate NET vivo. Results Plasminogen deficiency resulted increased deposition, infiltration, inflammatory factors concentration, alveolar resorption After treated by vitro, expression factors, mtROS, enriched mitochondrial DNA (mtDNA) upregulated, which reversed Mito‐TEMPO Moreover, alleviated inflammation mice. Conclusions showed that gingiva induced mice, was depending increasing mtROS.
Language: Английский
Citations
3
Small Science, Journal Year: 2024, Volume and Issue: unknown
Published: June 21, 2024
Neutrophil extracellular traps (NETs) formed by neutrophils are netlike scaffolds that mainly contain DNA and a variety of granule proteins. Many stimuli can lead to the NET formation through independent molecular pathways. Clinically, abundance NETs is correlated with poor tumor prognosis. The biological actions complex diverse, including promoting progression, awakening dormant cancer cells, resulting in immunosuppression support growth metastasis. Therefore, NET‐associated pathological processes provide an important clue for both diagnostic imaging alternative therapies many kinds cancers. In recent years, scientists’ efforts have focused on developing novel probes visualize therapeutic strategies degrading or inhibiting its block their pro‐tumoral functions. this review, development evaluation NETs‐targeted intervention progress therapy on.
Language: Английский
Citations
1
Analytica Chimica Acta, Journal Year: 2024, Volume and Issue: 1338, P. 343549 - 343549
Published: Dec. 20, 2024
Language: Английский
Citations
1
Acta Diabetologica, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 21, 2024
Language: Английский
Citations
0