MiRNAs function in the development of resistance against doxorubicin in cancer cells: targeting ABC transporters DOI Creative Commons
Xinyan Lu, Hongxu Jin

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 29, 2024

Resistance to chemotherapeutic agents poses a significant challenge in cancer treatment, particularly with doxorubicin, widely used drug for various cancers, including breast cancer, leukaemia, osteosarcoma, and gastrointestinal cancers. This review aims elucidate the critical role of microRNAs (miRNAs) development doxorubicin resistance, focusing on their interactions ATP-binding cassette (ABC) transporters. Despite extensive research, molecular mechanisms governing resistance still need be completed, regarding regulatory influence miRNAs ABC transporter expression. By analyzing current literature, this identifies notable gap: lack comprehensive insight into how specific modulate expression activity transporters cells, contributing resistance. We systematically examine recent findings interplay between transporters, providing detailed assessment potential therapeutic strategies that leverage miRNA modulation overcome Ultimately, underscores significance integrating research existing frameworks enhance efficacy treatment.

Language: Английский

The roles of lncRNAs in the development of drug resistance of oral cancers DOI Open Access
Wenjing Wang, Yi Liu, Jianan Wu

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 180, P. 117458 - 117458

Published: Oct. 15, 2024

Language: Английский

Citations

5
Unlocking Exosome Therapeutics: The Critical Role of Pharmacokinetics in Clinical Applications DOI
Krishna Yadav, Kantrol Kumar Sahu,

Sucheta

et al.

Tissue and Cell, Journal Year: 2025, Volume and Issue: 93, P. 102749 - 102749

Published: Jan. 23, 2025

Language: Английский

Citations

0
Mechanisms behind the LncRNAs-mediated regulation of paclitaxel (PTX) resistance in human malignancies DOI
Ali G. Alkhathami,

Harikumar Pallathadka,

Sejal Shah

et al.

Experimental Cell Research, Journal Year: 2025, Volume and Issue: unknown, P. 114434 - 114434

Published: Feb. 1, 2025

Language: Английский

Citations

0
Regulation of autophagy by non-coding RNAs in human glioblastoma DOI

Mehran Molavand,

Niloufar Ebrahimnezhade,

Arash Kiani

et al.

Medical Oncology, Journal Year: 2024, Volume and Issue: 41(11)

Published: Oct. 7, 2024

Language: Английский

Citations

1
Targeting non-coding RNAs as a promising biomarker in peritoneal metastasis: Background, mechanism, and therapeutic approach DOI Open Access
Yiping Zhang, Jun Xie

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 179, P. 117294 - 117294

Published: Sept. 2, 2024

Peritoneal metastasis (PM) pathophysiology is complex and not fully understood. PM, originating from gastrointestinal (GI) cancer, a condition that significantly worsens patient prognosis due to its nature limited treatment options. The non-coding RNAs (ncRNAs) have been shown play pivotal roles in cancer biology, influencing tumorigenesis, progression, metastasis, therapeutic resistance. Increasing evidence has demonstrated the regulatory functions of different classes ncRNAs, including microRNAs (miRNAs) long (lncRNAs) PM. Identifying biomarkers for early detection PM crucial step towards improving outcomes, how ncRNA profiles correlate with survival rates, response therapy, recurrence risks raised much attention recent years. Additionally, exploring innovative approaches utilizing such as targeted therapy gene silencing, may offer new horizons treating this dire condition. Recent advances systemic treatments development novel loco-regional therapies opened doors multimodal approaches. Radical surgeries combined hyperthermic intraperitoneal chemotherapy (HIPEC) promising results, leading extended survival. Current research focused on molecular characterization which developing future strategies. By summarizing latest findings, study underscores transformative potential ncRNAs enhancing diagnosis, prognosis, GI paving way more personalized effective clinical

Language: Английский

Citations

0
MiRNAs function in the development of resistance against doxorubicin in cancer cells: targeting ABC transporters DOI Creative Commons
Xinyan Lu, Hongxu Jin

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 29, 2024

Resistance to chemotherapeutic agents poses a significant challenge in cancer treatment, particularly with doxorubicin, widely used drug for various cancers, including breast cancer, leukaemia, osteosarcoma, and gastrointestinal cancers. This review aims elucidate the critical role of microRNAs (miRNAs) development doxorubicin resistance, focusing on their interactions ATP-binding cassette (ABC) transporters. Despite extensive research, molecular mechanisms governing resistance still need be completed, regarding regulatory influence miRNAs ABC transporter expression. By analyzing current literature, this identifies notable gap: lack comprehensive insight into how specific modulate expression activity transporters cells, contributing resistance. We systematically examine recent findings interplay between transporters, providing detailed assessment potential therapeutic strategies that leverage miRNA modulation overcome Ultimately, underscores significance integrating research existing frameworks enhance efficacy treatment.

Language: Английский

Citations

0