Novel Multilayer Antimicrobial Urinary Catheter Material with Antimicrobial Properties DOI Creative Commons

Benjamin Gambrill,

Fabrizio Pertusati, Iqbal Shergill

et al.

Materials Advances, Journal Year: 2024, Volume and Issue: 6(3), P. 1020 - 1030

Published: Dec. 28, 2024

Urinary catheters are commonly used in medical practice to drain and monitor urine of patients. However, urinary catheterisation is associated with the risk developing catheter-associated tract infections (CAUTIs), which can result life-threatening sepsis that requires antibiotics for treatment. Using layer-by-layer (LbL) technique, we assembled a multilayer catheter comprising nine quadruple layers (9QL) alginate, chlorhexidine (CHX), alginate poly(β-amino ester) (PBAE) built upon an amino-functionalised silicone. The prepared materials were tested pre-packaged storage conditions sterilisation techniques. daily release CHX was measured at pH 7.4 5 simulated 37 °C, determine antimicrobial affect. detected minimum 14 days PBS (pH 7.4), media, samples against Incubation material bacterial cultures 24 hours restricted growth compared incubation standard material. inhibition concentration clinically isolated infection (UTI) strains range 19.4-77.4 µM, released could indirectly prevent up days. Based on from samples, hydrolysis PBAE gradual, resulting greater number preventing growth, followed by then urine. To best our knowledge, this first report use association drug.

Language: Английский

Biofilm Resilience: Molecular Mechanisms Driving Antibiotic Resistance in Clinical Contexts DOI Creative Commons
Ahmad Almatroudi

Biology, Journal Year: 2025, Volume and Issue: 14(2), P. 165 - 165

Published: Feb. 6, 2025

Healthcare-associated infections pose a significant global health challenge, negatively impacting patient outcomes and burdening healthcare systems. A major contributing factor to healthcare-associated is the formation of biofilms, structured microbial communities encased in self-produced extracellular polymeric substance matrix. Biofilms are critical disease etiology antibiotic resistance, complicating treatment infection control efforts. Their inherent resistance mechanisms enable them withstand therapies, leading recurrent increased morbidity. This review explores development biofilms their dual roles disease. It highlights structural protective functions EPS matrix, which shields populations from immune responses antimicrobial agents. Key molecular biofilm including restricted penetration, persister cell dormancy, genetic adaptations, identified as barriers effective management. implicated various clinical contexts, chronic wounds, medical device-associated infections, oral complications, surgical site infections. prevalence hospital environments exacerbates challenges underscores urgent need for innovative preventive therapeutic strategies. evaluates cutting-edge approaches such DNase-mediated disruption, RNAIII-inhibiting peptides, DNABII proteins, bacteriophage nanoparticle-based solutions, coatings, lock therapies. also examines associated with biofilm-related diagnostic difficulties, disinfectant economic implications. emphasizes multidisciplinary approach importance understanding dynamics, role pathogenesis, advancements strategies combat biofilm-associated effectively settings. These insights aim enhance reduce burden diseases.

Language: Английский

Citations

1
Piezoelectrically-activated antibacterial catheter for prevention of urinary tract infections in an on-demand manner DOI Creative Commons
Xiaofeng Duan,

Yongde Xu,

Zhifa Zhang

et al.

Materials Today Bio, Journal Year: 2024, Volume and Issue: 26, P. 101089 - 101089

Published: May 11, 2024

Catheter-associated urinary tract infection (CAUTI) is a common clinical problem, especially during long-term catheterization, causing additional pain to patients. The development of novel antimicrobial coatings needed prolong the service life catheters and reduce incidence CAUTIs. Herein, we designed an catheter coated with piezoelectric zinc oxide nanoparticles (ZnO NPs)-incorporated polyvinylidene difluoride-hexafluoropropylene (ZnO-PVDF-HFP) membrane. ZnO-PVDF-HFP could be stably onto silicone simply by one-step solution film-forming method, very convenient for industrial production. In vitro, it was demonstrated that coating significantly inhibit bacterial growth formation biofilm under ultrasound-mediated mechanical stimulation even after 4 weeks. Importantly, on off activity as well strenth antibacterial property controlled in adaptive manner via ultrasound. rabbit model, ZnO-PVDF-HFP-coated reduced CAUTIs compared clinically-commonly used assistance ultrasonication, no side effect detected. Collectively, study provided prevent occurance CAUTIs, whose on-demand manner, situation promising application.

Language: Английский

Citations

5
Dual‐Layer Nanoengineered Urinary Catheters for Enhanced Antimicrobial Efficacy and Reduced Cytotoxicity DOI Creative Commons

Dong‐Sung Won,

Hyun Lee, Yubeen Park

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: July 22, 2024

Abstract Catheter‐associated urinary tract infection (CAUTI) is the most common healthcare‐associated infection; however, current therapeutic strategies remain insufficient for standard clinical application. A novel catheter featuring a dual‐layer nanoengineering approach using zinc (Zn) and silver nanoparticles (AgNPs) successfully fabricated. This design targets microbial resistance, minimizes cytotoxicity, maintains long‐term efficacy. The inner AgNPs layer provides immediate antibacterial effects against UTI pathogens, while outer porous Zn controls zero‐order Ag release generates reactive oxygen species, thus enhancing bactericidal performance. Enhanced properties of Zn/AgNPs‐coated catheters are observed, resulting in 99.9% E. coli 99.7% S. aureus reduction, respectively. significantly suppresses biofilm with sludge formation compared to AgNP‐coated uncoated (all, p < 0.05). Zn/AgNP‐coated rabbit model demonstrated durable, effective barrier bacterial colonization, maintaining antimicrobial during indwelling period reduced inflammation epithelial disruption AgNP groups. innovation has potential revolutionize medical devices, particularly applications requiring implantation. Although further preclinical studies required verify its efficacy safety, this strategy seems be promising preventing CAUTI‐related complications.

Language: Английский

Citations

5
Exploring the Anti‐Adherence Potential of Skt35 to Combat Catheter‐Associated Staphylococcus aureus Infections: Efficacy, Toxicity and Mechanism of Action DOI Open Access
Ramu Meenatchi,

S. Priya,

Chakraborty Shreya

et al.

Chemistry & Biodiversity, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 20, 2025

ABSTRACT Catheter‐associated urinary tract infections (CAUTIs), often caused by biofilm‐forming Staphylococcus aureus , present significant clinical challenges. Skt35, a dioxopiperidinamide derivative of cinnamic acid, was investigated for its potential antibacterial and antibiofilm activities against S. biofilms. The effect Skt35 assessed using the zone inhibition microdilution methods, revealing minimum inhibitory concentration (MIC) 250 µM. Antibiofilm properties were confirmed through crystal violet assays, scanning electron microscopy confocal laser microscopy, showing biofilm at Sub‐MIC. In an in vitro bladder model, Skt35‐coated silicone catheter tubes exhibited antiadhesive effects. Zebrafish embryo tests indicated no toxicity concentrations up to 125 Molecular docking simulation analysis revealed strong binding affinities Accessory Gene Regulator A (‐7.9 kcal/mol) Lux Small protein (‐4.96 kcal/mol), suggesting disruption quorum sensing gene expression making it promising candidate coatings prevent CAUTIs.

Language: Английский

Citations

0
Dual-Function Hydrogel Coating on Silicone Urinary Catheters with Durable Antibacterial Property and Lubricity DOI Creative Commons

Shuai Gao,

Wei Zeng, Zheng Liu

et al.

Gels, Journal Year: 2025, Volume and Issue: 11(2), P. 128 - 128

Published: Feb. 10, 2025

Silicone urinary catheters are broadly employed in medical practice. However, they susceptible to inducing catheter-associated tract infections (CAUTIs) due bacterial adherence the catheter's surface, and exhibit a high friction coefficient, which can greatly affect their effectiveness functionality. Thus, development of silicone catheter with antibacterial properties lubricity is strong demand. We hereby developed poly(vinyl acetate) carrier coating load chlorhexidine acetate applied hydrogel primarily composed polyvinylpyrrolidone (PVP) poly(ethylene glycol) diacrylate (PEGDA), was then coated onto cured through thermal curing process could provide lubricity. Subsequently, we analyzed its surface characteristics assessed property, lubricity, cytotoxicity, potential for vaginal irritation. The findings from Fourier transform infrared spectrometer (FTIR), scanning electron microscope (SEM), water contact angle (WCA), inhibition zone measurements, coefficient analysis confirmed successful modification catheter. Additionally, outcomes cytotoxicity irritation assessments demonstrated that dual-function coating-coated outstanding biocompatibility. This study illustrates prepared possess durable thus gives them broad clinical application prospects.

Language: Английский

Citations

0
Performance evaluation of ciprofloxacin loaded curcumin-exopolysaccharide bioconjugate carrier for eradication of bacterial biofilms DOI

Chandrika Gupta,

Sudip Kumar Ghosh, Ramkrishna Sen

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142946 - 142946

Published: April 1, 2025

Language: Английский

Citations

0
Fabrication of highly porous polymeric coatings loaded with rifampicin for preventing catheter-associated urinary tract infections DOI

Ping Lin,

H.L. Ni,

Wenjie Wang

et al.

Progress in Organic Coatings, Journal Year: 2025, Volume and Issue: 203, P. 109190 - 109190

Published: March 6, 2025

Language: Английский

Citations

0
Enzymatically Built Nanoenabled Antimicrobial Coating on Urinary Catheters DOI Creative Commons
Antonio Puertas‐Segura,

A. Gala Morena,

Sílvia Pérez‐Rafael

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(30), P. 39129 - 39139

Published: July 23, 2024

Catheter-associated urinary tract infections represent a major share of nosocomial infections, and are associated with longer periods hospitalization huge financial burden. Currently, there only handful commercial materials that reduce biofilm formation on catheters, mostly relying silver alloys. Therefore, we combined silver-phenolated lignin nanoparticles poly(carboxybetaine) zwitterions to build composite antibiotic-free coating bactericidal antifouling properties. Importantly, the versatile chemistry enabled in situ, enabling both nanoparticle grafting radical polymerization by using oxidative activity laccase. The resulting surface efficiently prevented nonspecific protein adsorption reduced bacterial viability catheter more than 2 logs under hydrodynamic flow, without exhibiting any apparent signs cytotoxicity. Moreover, said functionality was maintained over week vitro vivo, whereby animal models showed excellent biocompatibility.

Language: Английский

Citations

2
Enhanced antifouling and anti-swarming properties poly (sulfobetaine methacrylate-co-2-hydroxy-3-phenoxypropyl acrylate) hydrogel coatings for urinary catheters DOI Creative Commons
Chenghao Yao,

Xiao Teng,

Dan Sun

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 245, P. 114277 - 114277

Published: Sept. 27, 2024

Language: Английский

Citations

2
Advanced Antibacterial Strategies for Combatting Biomaterial‐Associated Infections: A Comprehensive Review DOI Creative Commons
Esra Kasapgil, Manuela Garay‐Sarmiento, César Rodriguez‐Emmenegger

et al.

Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, Journal Year: 2024, Volume and Issue: 16(6)

Published: Nov. 1, 2024

ABSTRACT Biomaterial‐associated infections (BAIs) pose significant challenges in modern medical technologies, being a major postoperative complication and leading cause of implant failure. These significantly risk patient health, resulting prolonged hospitalization, increased morbidity mortality rates, elevated treatment expenses. This comprehensive review examines the mechanisms driving bacterial adhesion biofilm formation on biomaterial surfaces, offering an in‐depth analysis current antimicrobial strategies for preventing BAIs. We explore antimicrobial‐eluting biomaterials, contact‐killing antifouling coatings, emphasizing application polymer brushes devices. Recent advancements multifunctional which integrate multiple superior protection against BAIs, are also discussed. By evaluating advantages limitations these strategies, this aims to guide design development highly efficient biocompatible biomaterials. highlight potential routes that facilitate transition from laboratory research clinical applications. Additionally, we provide insights into synthetic biology as novel approach combat resistance. aspires inspire future innovation, ultimately improving outcomes advancing device technology.

Language: Английский

Citations

2