Applied Sciences,
Journal Year:
2025,
Volume and Issue:
15(6), P. 2962 - 2962
Published: March 10, 2025
Additive
manufacturing
must
be
highlighted
as
an
innovative
technology
with
the
capacity
to
produce
objects
complex
and
customized
geometries
using
a
diverse
range
of
raw
materials.
Despite
its
significant
potential,
research
compiling
evaluating
specific
contributions
additive
in
field
chemical
engineering
was
scarce
both
quantitative
qualitative
terms.
Similarly,
application
tools
has
not
been
specifically
reviewed.
Therefore,
this
work
conducted
comprehensive
review
scientific
literature
covering
these
issues
bibliometric
analysis.
The
search
encompassed
entirety
up
year
2023,
yielding
3761
documents
Scopus
database.
principal
findings
analysis
indicated
exponential
growth
number
publications,
which
suggests
rising
interest
field.
revealed
that
English
dominant
language
documents,
articles
constituted
most
common
document
type,
indicating
quality
maturity
research.
thematic
distribution
proved
multidisciplinary,
primary
focus
on
materials
science,
well
basic
sciences.
United
States
foremost
contributor
production,
followed
by
China
Germany.
Keyword
scrutiny
cited
enabled
identification
main
topics,
were
found
include
biofabrication
biomedical
applications.
Moreover,
network
software
SciMAT
(v
1.1.06)
yielded
corresponding
strategic
diagrams,
evolution
maps,
networks,
provided
overview
trends
gaps.
considerable
other
purposes
overshadowed
applications
within
field,
while
potential
could
make
have
eclipsed
too.
On
one
hand,
focused
process
intensification
benefit
from
design
advanced
microreactors
miniaturized
devices
or
more
efficient
heat
exchangers,
catalysts,
adsorbents
separation
membranes
structures.
life
cycle
assessment
optimization
are
established
should
extensively
employed
context
ensure
sustainable
outcome.
Materials & Design,
Journal Year:
2022,
Volume and Issue:
220, P. 110856 - 110856
Published: June 16, 2022
Calcium
silicate
(CS)
is
a
suitable
substrate
for
bone
tissue
engineering
because
it
can
provide
bioactive
ions
like
Si4+
and
Ca2+
to
promote
regeneration.
However,
the
rapid
degradation
of
CS
leads
pH
problems
does
not
match
rate
osteogenesis.
The
3D
printed
scaffolds
were
immersed
in
Polycaprolactone
(PCL)
solution
obtain
PCL-coated
with
improved
mechanical
biological
properties.
Finite
element
method
(FEM)
analysis
found
that
PCL
impregnation
has
effect
stress
shielding
defect
healing,
effectively
improving
properties
porous
scaffolds.
was
significantly
slowed
down
Tris
buffer.
After
4
weeks
degradation,
compressive
strength
remained
at
23.34
MPa,
maintaining
reliable
coating
reduced
scaffolds,
value
Si
ion
concentration
Dulbecco's
modified
Eagle's
medium
(DMEM)
soaked
by
more
favorable
cell
survival.
results
show
enhance
proliferation
osteogenic
differentiation,
demonstrating
potential
applicability
applications.
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
13(27)
Published: July 9, 2024
Abstract
Three‐dimensional
(3D)
printed
medical
devices
include
orthopedic
and
craniofacial
implants,
surgical
tools,
external
prosthetics
that
have
been
directly
used
in
patients.
While
the
advances
of
additive
manufacturing
techniques
production
on
rise,
clinical
translation
living
cellular
constructs
face
significant
limitations
terms
regulatory
affairs,
process
technology,
materials
development.
In
this
perspective,
current
status‐quo
3D
four‐dimensional
(4D)
(bio)printing
is
summarized,
advancements
are
discussed
challenges
need
to
be
addressed
for
improved
industrial
applications
bioprinting
highlighted.
It
focused
a
multidisciplinary
approach
discussing
key
translational
considerations,
from
perspective
industry,
bodies,
funding
strategies,
future
directions.
Macromolecular Chemistry and Physics,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 6, 2025
Abstract
Currently,
material
extrusion‐based
additive
manufacturing
(MEAM)
technique,
also
known
as
fused
filament
fabrication
(FFF)
technique
has
been
widely
used
to
prepare
customized
porous
scaffolds
for
bone
tissue
engineering.
However,
often
lack
desirable
osteogenic
properties
due
the
poor
hydrophilicity
of
polymer
materials
FFF
technique.
In
this
work,
biocompatible
suitable
are
prepared
by
blending
polycaprolactone
(PCL),
polylactic
acid
(PLA),
and
tricalcium
phosphate
(TCP)
at
various
compositions.
These
composite
subsequently
printed
into
cylindrical
with
controllable
pore
sizes
ranging
from
200–800
µm,
regulating
infill
density
during
process.
The
FFF‐printed
have
highest
modulus
a
PLA/PCL
ratio
0.7
size
≈
200
µm.
Furthermore,
surface
treatment
is
applied
these
in
sodium
hydroxide
solution.
As
result,
roughness,
serum
adsorption
significantly
enhanced.
More
importantly,
surface‐treated
can
promote
differentiation
MC3T3‐E1
cells,
comparable
commercial
Bio‐Oss
substitutes.
Thus,
study
offers
cost‐effective
development
bioactive
potential
engineering
applications.
npj Regenerative Medicine,
Journal Year:
2023,
Volume and Issue:
8(1)
Published: Sept. 29, 2023
During
bone
regeneration,
the
periosteum
acts
as
a
carrier
for
key
regenerative
cues,
delivering
osteochondroprogenitor
cells
and
crucial
growth
factors
to
injured
bone.
We
developed
biocompatible,
3D
polycaprolactone
(PCL)
melt
electro-written
membrane
act
mimetic
periosteum.
Poly
(ethyl
acrylate)
coating
of
PCL
allowed
functionalization,
mediated
by
fibronectin
low
dose
recombinant
human
BMP-2
(rhBMP-2)
(10-25
μg/ml),
resulting
in
efficient,
sustained
osteoinduction
vitro.
In
vivo,
rhBMP-2
functionalized
demonstrated
potential
treatment
rat
critical-size
femoral
defects
with
highly
efficient
healing
functional
recovery
(80%-93%).
Mimetic
has
also
proven
be
cell
delivery,
observed
through
migration
transplanted
periosteum-derived
mesenchymal
defect
their
survival.
Ultimately,
its
ability
deliver
stem
morphogens
an
site,
exposing
therapeutic
translational
vivo
when
combined
unprecedentedly
doses.
Biomedical Materials,
Journal Year:
2024,
Volume and Issue:
19(5), P. 055018 - 055018
Published: July 24, 2024
Bioactive
and
biodegradable
scaffolds
that
mimic
the
natural
extracellular
matrix
of
bone
serve
as
temporary
structures
to
guide
new
tissue
growth.
In
this
study,
3D-printed
composed
poly
(lactic
acid)
(PLA)-tricalcium
phosphate
(TCP)
(90-10
wt.%)
were
modified
with
1%,
5%,
10
wt.%
ZnO
enhance
regeneration.
A
commercial
chain
extender
named
Joncryl
was
incorporated
alongside
ensure
printability
composites.
Filaments
manufactured
using
a
twin-screw
extruder
subsequently
used
print
3D
via
fused
filament
fabrication
(FFF).
The
exhibited
homogeneous
distribution
TCP
particles,
reproducible
structure
300
μm
pores,
mechanical
properties
suitable
for
engineering,
an
elastic
modulus
around
100
MPa.
addition
resulted
in
enhanced
surface
roughness
on
scaffolds,
particularly
microparticles,
achieving
values
up
241
nm.
This
rougher
topography
responsible
enhancing
protein
adsorption
increase
85%
compared
PLA-TCP
matrix.
Biological
analyses
demonstrated
presence
promotes
mesenchymal
stem
cell
(MSC)
proliferation
differentiation
into
osteoblasts.
Alkaline
phosphatase
(ALP)
activity,
important
indicator
early
osteogenic
differentiation,
increased
29%.
composite
containing
5%
microparticles
optimized
degradation
rate
bioactivity,
indicating
its
promising
potential
repair
applications.
