Journal of Nephrology, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 21, 2024
Language: Английский
Journal of Bone and Mineral Research, Journal Year: 2024, Volume and Issue: 39(11), P. 1539 - 1552
Published: Aug. 20, 2024
Abstract Mendelian randomization (MR) is a genetic epidemiological technique that uses variation to infer causal relationships between modifiable exposures and outcome variables. Conventional observational studies are subject bias from range of sources; MR analyses can offer an advantage in they less prone as use variants inherited at conception “instrumental variables”, which proxies exposure. However, with all research tools, must be carefully designed yield valuable insights into outcomes, avoid biased or misleading results undermine the validity inferences drawn study. In this review, we outline Mendel’s laws inheritance, assumptions principles underlie MR, study designs methods, how applied reported. Using example serum phosphate concentrations on liability kidney stone disease illustrate estimates may visualized and, finally, contextualize bone mineral including exemplifying could employed inform clinical future guidelines concerning BMD fracture risk. This review provides framework enhance understanding used triangulate evidence progress metabolism strive effects health disease.
Language: Английский
Citations
8
Biomedicine & Pharmacotherapy, Journal Year: 2025, Volume and Issue: 184, P. 117912 - 117912
Published: Feb. 16, 2025
Language: Английский
Citations
0
Clinical and Experimental Medicine, Journal Year: 2025, Volume and Issue: 25(1)
Published: May 25, 2025
Diabetic neuropathy (DN) is a common complication of type 2 diabetes mellitus (T2DM), yet its impact on bone mineral density (BMD) remains unclear. This study combines cross-sectional and meta-analytic methods to comprehensively explore the relationship between DN osteoporosis in T2DM patients. The included 523 patients, classified into non-DN groups. BMD was measured using dual-energy X-ray absorptiometry (DXA), multivariate analysis identified osteoporosis-related factors. meta-analysis studies published from 1999 2021, comparing patients with without DN. results showed that while significant differences clinical characteristics biochemical indices (such as age, HbA1c, 25(OH) vitamin D levels) were observed groups, no association found after adjusting for covariates like body mass index blood pressure. Additionally, confirmed across skeletal sites, including lumbar spine, hip, femoral neck. These findings suggest may indirectly affect health through alterations metabolism formation markers), direct limited. study's limitations include design, which restricts causal inference, retrospective data collection, underscoring need prospective further elucidate mechanisms behind DN's effects health. highlight complex interplay factors influencing risk underscore importance multifactorial approach management this population.
Language: Английский
Citations
0
European Journal of Pharmacology, Journal Year: 2024, Volume and Issue: 976, P. 176619 - 176619
Published: April 26, 2024
Language: Английский
Citations
2
Sleep Medicine, Journal Year: 2024, Volume and Issue: 119, P. 480 - 487
Published: May 17, 2024
Language: Английский
Citations
2
Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14
Published: Sept. 10, 2024
Currently, Sodium-glucose cotransporter 2 (SGLT2) inhibitors demonstrate additional effects beyond glucose control on the gut microbiota and circulating metabolites. The metabolites have been found to be useful in elucidating potential biological mechanisms of pulmonary diseases. Therefore, our study aims investigate mediating SGLT2 inhibition 10 diseases through Mendelian randomization (MR) research.
Language: Английский
Citations
1
Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15
Published: Sept. 17, 2024
Background While Sodium-glucose cotransporter 2 (SGLT2) inhibitors are effective in managing diabetes and reducing cardiovascular risk, concerns about their association with lower limb complications, including, osteomyelitis, ulcers, peripheral artery disease (PAD), persist. This study employs Mendelian Randomization (MR) to assess the causal relationship between SGLT2 these safety outcomes. Methods A two-sample drug-target MR approach was used, complemented by a one-sample genetic analysis. Six SNPs were selected as instrumental variables proxy effect of inhibition. Primary outcomes major outcomes, including PAD, cellulitis. The primary analytical method generalized inverse variance-weighted (IVW) approach, along several sensitivity analyses. Results analysis indicated no significant genetically proxied inhibition most studied However, PAD observed, necessitating careful interpretation due discrepancies IVW MR-Egger results. Sensitivity analyses supported findings, showing little evidence heterogeneity or directional pleiotropy. Conclusion suggests that may not be significantly associated an increased risk cellulitis, patients type diabetes. complex highlights need for further research. These findings contribute understanding profile inhibitors, supporting continued use management while underlining importance continuous monitoring.
Language: Английский
Citations
1
Frontiers in Cardiovascular Medicine, Journal Year: 2024, Volume and Issue: 11
Published: April 25, 2024
To investigate the causal contributions of Sodium-glucose cotransporter 2 (SGLT2) inhibition on Heart Failure (HF) and identify circulating proteins that mediate SGLT2 inhibition's effects HF.
Language: Английский
Citations
0
BMC Musculoskeletal Disorders, Journal Year: 2024, Volume and Issue: 25(1)
Published: Aug. 29, 2024
This study aimed to evaluate the causal relationship between Interleukin-27 (IL-27) and osteoporosis by bidirectional Mendelian randomization (MR) analysis.
Language: Английский
Citations
0
Journal of Nephrology, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 21, 2024
Language: Английский
Citations
0