The effect and mechanism of areca nut in ovarian cancer were investigated based on network pharmacology, molecular docking, and in vitro experiments

Biochemical and Biophysical Research Communications, Journal Year: 2025, Volume and Issue: unknown, P. 151943 - 151943

Published: May 1, 2025

Language: Английский

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Development and Evaluation of a Novel Chlorogenic Acid Analogue with Enhanced Antioxidant Activity in Vitro

Journal of Molecular Structure, Journal Year: 2025, Volume and Issue: unknown, P. 142626 - 142626

Published: May 1, 2025

Language: Английский

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Cardioprotective effect of Sanguisorba minor against isoprenaline-induced myocardial infarction in rats

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: Dec. 21, 2023

Introduction: Oxidative stress is a major instigator of various cardiovascular diseases, including myocardial infarction (MI). Despite available drugs, there still an increased need to look for alternative therapies or identify new bioactive compounds. Sanguisorba minor ( S. ) native herb characterized by its potent antioxidant activity. This study was designed evaluate the effect against isoprenaline-induced MI. Methods: Rats were treated with hydro-ethanolic extract aerial parts at doses 100 300 mg/kg orally 9 days. Isoprenaline injected subcutaneously dose 85 on days 8 and 9. Then, activities cardiac injury markers troponin (cTnT), lactate dehydrogenase (LDH), creatinine kinase muscle brain (CK-MB), phosphokinase (CPK), enzymes in serum determined. Malondialdehyde (MDA) thiol content measured tissue, histopathological analysis conducted. Results: Our results show that isoprenaline levels cTnT, LDH, CK-MB, CPK p < 0.001) elevated MDA tissue. also reduced superoxide dismutase (SOD), catalase, 0.001). Importantly, abolished MI elevating SOD catalase 0.001), reducing MDA, diminishing Histopathological studies tissue showed significantly attenuated extract. Conclusion: suggest could abrogate toxicity due ability mitigate oxidative stress.

Language: Английский

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Elucidating the chemical profile and biological studies of Verbascum diversifolium Hochst. extracts

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Jan. 30, 2024

The present study was designed to evaluate the chemical composition, antioxidant, enzyme inhibition and cytotoxic properties of different extracts from aerial parts V. diversifolium (family Scrophulariaceae), a plant that is native Lebanon, Syria Turkey. Six extracts, namely, hexane, dichloromethane (DCM), ethyl acetate (EtOAc), ethanol (EtOH), 70% EtOH, water (aqueous) were prepared by maceration. EtOH extract predominated presence rutin (4280.20 μg g −1 ) p -coumaric acid (3044.01 while highest accumulation kaempferol-3-glucoside (1537.38 ), caffeic (130.13 4-hydroxy benzoic (465.93 recorded in aqueous, EtOAc respectively. (46.86 mg TE/g) (46.33 displayed DPPH radical scavenging result. Both these along with aqueous one, exerted ABTS result (73.03–73.56 TE/g). revealed most potent anti-AChE (2.66 2.64 GALAE/g) anti-glucosidase (1.07 1.09 mmol ACAE/g) activities. efficacious inhibiting proliferation prostate cancer (DU-145) cells an IC 50 8.71 μg/mL Selectivity Index 3.7. In conclusion, this appraised use as potential therapeutic source for future development phytopharmaceuticals target specific oxidative stress-linked diseases including diabetes, cancer, cardiovascular disease, Alzheimer’s disease among others.

Language: Английский

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Empagliflozin attenuates radiation-induced hematopoietic damage via NOX-4/ROS/p38 pathway

Life Sciences, Journal Year: 2024, Volume and Issue: 341, P. 122486 - 122486

Published: Feb. 6, 2024

Language: Английский

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