Journal of Endocrinological Investigation, Journal Year: 2025, Volume and Issue: unknown
Published: April 24, 2025
Language: Английский
Frontiers in Bioscience-Landmark, Journal Year: 2024, Volume and Issue: 29(6), P. 223 - 223
Published: June 20, 2024
Endothelial cell dysfunction is a complex process involving various causes, early and late events, subsequent consequences. This review provides an overview of each aspect outlines therapeutic interventions targeting these stages. Causes endothelial encompass spectrum risk factors including hypertension, diabetes, smoking, obesity, inflammation, oxidative stress, genetic predispositions. Early events such as activation, inflammatory response, dysregulated vasomotor tone precede like apoptosis, microvascular rarefaction. The consequences include remodelling, neovascularization, organ dysfunction, clinical manifestations, highlighting the diverse impacts across multiple systems. While depicted linearly, progression dynamic, influenced by underlying cause affected vascular bed. Understanding dynamics crucial for tailoring interventions, ranging from lifestyle modifications to targeted therapies, address causes effects effectively. Here we provide comprehensive understanding that essential developing strategies mitigate impact this dysregulation on health cardiovascular diseases progression.
Language: Английский
Citations
5
BMC Endocrine Disorders, Journal Year: 2024, Volume and Issue: 24(1)
Published: March 4, 2024
Abstract Objective This study aimed to examine the diagnostic predictive value of long non-coding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1(MALAT1) and NOD-like receptor protein 3(NLRP3) expression in patients with type 2 diabetes mellitus(T2DM) lower extremity atherosclerosis disease (LEAD). Methods A total 162 T2DM were divided into LEAD group (T2DM + group) alone group). The lncRNA MALAT1 NLRP3 levels measured peripheral blood, their correlation was examined. Least absolute shrinkage selection operator (LASSO) regression model used screen for best predictors LEAD, multivariate logistic establish a construct nomogram. effectiveness nomogram assessed using receiver operating characteristic (ROC) curve, area under curve (AUC), calibration decision analysis (DCA). Results significantly greater than those ( P <0.001), level positively correlated that r = 0.453, <0.001). results LASSO combined showed age, smoking, systolic blood pressure (SBP), NLRP3, influencing factors LEAD( <0.05). ROC comparison: discriminatory ability (AUC 0.898), 0.804), 0.794) other indicators, greatest. Calibration curve: consistent predicting occurrence (Cindex 0.898). Decision net benefit rates obtained from models clinical intervention decision-making individual within model. Conclusion increased while revealing between NLRP3. found as potential biomarker LEAD.
Language: Английский
Citations
4
Diabetes Metabolic Syndrome and Obesity, Journal Year: 2025, Volume and Issue: Volume 18, P. 51 - 59
Published: Jan. 1, 2025
This study aims to analyze the impact of serum C-peptide levels in patients with newly diagnosed type 2 diabetes (T2DM) on 10-year risk atherosclerotic cardiovascular disease (ASCVD). A total 1923 T2DM were selected and categorized into four groups based interquartile range fasting (FCP) levels: Q1 group (FCP≤0.568 ng/mL), Q2 (0.568 < FCP≤0.751 Q3 (0.751 FCP≤0.980 Q4 (FCP > 0.980 ng/mL). Clinical data collected, China-PAR model was employed evaluate score ASCVD within 10 years. Additionally, correlation between FCP analyzed. As quartiles increased, exhibited a gradual increase. The ng/mL significantly higher than that other groups, noted differences related gender weight. Multiple linear regression analysis indicated that, even after adjusting for confounding factors such as gender, age, body mass index (BMI), glycosylated hemoglobin, remained positive predictor risk. High are identified factor years T2DM.
Language: Английский
Citations
0
Journal of Diabetes Research, Journal Year: 2025, Volume and Issue: 2025(1)
Published: Jan. 1, 2025
Aims: This cross‐sectional study is aimed at determining whether systemic inflammation, diabetic autoantibodies, and islet β cell dysfunction play a role in the progression of macrovascular complications patients with autoimmune diabetes. Methods: 202 diabetes aged ≥ 35 years hospitalized Peking Union Medical College Hospital were enrolled this study. The divided into three groups based on severity peripheral atherosclerosis. Biomarkers function, other covariates validated to be associated collected. Correlations between atherosclerosis function examined using an ordinal logistic regression model. Results: Of patients, 39.1% male, median age 53 (43, 60) duration 96 (36, 216) months. 58 had no lesions arteries, 72 carotid or lower extremity rest both arteries. In multifactor test, positive cytoplasmic antibody (ICA) long‐term use lipid‐lowering agents independently after adjusting for duration. Conclusions: correlation ICA suggests inflammation early stage plays association need screening intervention dyslipidemia
Language: Английский
Citations
0
Theranostics, Journal Year: 2025, Volume and Issue: 15(8), P. 3551 - 3570
Published: Feb. 25, 2025
Diabetes mellitus (DM) is a chronic metabolic disorder that significantly affects various organ systems. The systemic effects of DM lead to numerous complications, with ocular manifestations being particular concern due their severity and impact on quality life. Hyperglycemia-induced damage often results in range lesions, including diabetic retinopathy (DR), keratopathy, cataracts, glaucoma. These conditions impose considerable physical discomfort patients place substantial economic burden healthcare advent nanotechnology has facilitated the development innovative therapeutic strategies for managing complications. This review highlights several common complications associated DM, focusing pathogenesis treatment strategies. Emphasis placed applications potential treating
Language: Английский
Citations
0
Physiological Reports, Journal Year: 2025, Volume and Issue: 13(6)
Published: March 1, 2025
C-peptide has a complex role in human physiology, but its effects are not fully understood. Studies have shown protective impact against diabetic complications, also that levels associate with cardiovascular events. Among the many applications to assess risk, circulating lipids widely used, and one of strongest biomarkers is apolipoprotein B. The aim this investigation was study association markers metabolic, inflammatory, or alterations limited group healthy individuals. Body mass index (BMI), lipids, other plasma were studied 28 consecutive individuals within age 30-50 years. results showed significant positive correlations between BMI (r = 0.498; p 0.007); hsCRP 0.530; 0.004); triglycerides 0.005); cholesterol 0.507; 0.006), LDL-cholesterol 0.550; 0.002), LDL/HDL ratio 0.460; 0.014); apoB 0.622; < 0.001), apoB/apoA1 0.563; 0.002); non-HDL 0.566; 0.002). According values, 16 overweight (BMI >25.0 kg/m2). If excluded, did only correlate 0.636; 0.026). To conclude, normal atherogenic individuals, even at weight. These suggest can be an early additional risk marker.
Language: Английский
Citations
0
Journal of Endocrinological Investigation, Journal Year: 2025, Volume and Issue: unknown
Published: April 24, 2025
Language: Английский
Citations
0