A systematic review and meta‐analysis of the prevalence and correlation of mild cognitive impairment in sarcopenia

Journal of Cachexia Sarcopenia and Muscle, Journal Year: 2022, Volume and Issue: 14(1), P. 45 - 56

Published: Dec. 18, 2022

Sarcopenia is a progressive skeletal muscle disorder involving the loss of mass and function, associated with an increased risk disability frailty. Though its prevalence in dementia has been studied, occurrence mild cognitive impairment (MCI) not well established. As MCI often prelude to dementia, our study aims investigate among individuals sarcopenia also ascertain whether independently MCI. The Cochrane Library, PubMed, Ovid, Embase Web Science were systematically searched for articles on and/or published from inception 1 February 2022. We reviewed available literature number calculated odds ratios (ORs) sarcopenia, respectively. Statistical analyses performed using meta package Stata, Version 12.0. A total 13 studies 27 428 patients included analysis. pooled participants was 20.5% (95% confidence interval [CI]: 0.140-0.269) sample 2923 cases high level heterogeneity (P < 0.001; I2 = 95.4%). overall 9.1% CI: 0.047-0.134, P 93.0%). For ORs, there 23 364 subjects mean age 73 years; adjusted OR between 1.46 1.31-1.62). Slight both ORs 0.46; 0%) noted across studies. relatively may be factor

Language: Английский

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Meta‐analysis on the interrelationship between sarcopenia and mild cognitive impairment, Alzheimer's disease and other forms of dementia

Journal of Cachexia Sarcopenia and Muscle, Journal Year: 2024, Volume and Issue: 15(4), P. 1240 - 1253

Published: May 7, 2024

Sarcopenia has been associated with adverse health outcomes, including cognitive dysfunction. However, its specific interrelationship neurocognitive disorders such as mild impairment (MCI), Alzheimer's disease (AD) or other types of dementia not thoroughly explored. This meta-analysis aims to summarize the existing evidence on this interrelationship. systematic review was pre-registered PROSPERO (CRD42022366309) and reported according Preferred Reporting Items for Systematic Reviews Meta-Analyses 2020 guidelines. Databases, PubMed, Embase, CINAHL, Scopus, Web Science, PEDro, SPORTDiscus Cochrane Central Register Controlled Trials, data registry ClinicalTrials.gov were searched from inception 8 June 2023. Observational studies (cross-sectional cohort) interventional reporting association prevalence sarcopenia in MCI, AD adults ≥50 years included. For meta-analysis, pooled odds ratios (OR) 95% confidence intervals (CI) calculated using random-effects/fixed-effects models. Subgroup analyses performed identify potential sources heterogeneity. A total 77 consisting 92 058 subjects finally included qualitative analysis (71 cross-sectional, 4 cohort 2 studies). Studies heterogeneous, different diagnostic criteria define both status. The majority (n = 38) Asian community-dwelling older adults. Most investigated (33/77) MCI (32/77). focusing forms dementia, two Lewy body one study Parkinson's whereas remaining did specify aetiology 21). Three explored between incident only sarcopenia. Two whether an exercise programme could prevent progression AD. information extracted 26 studies. significantly (pooled OR 1.58, CI 1.42-1.76) 14), 2.97, 2.15-4.08) 3) non-AD 1.68, 1.09-2.58) 9). significance magnitude associations differed subgroup by design, population, definition used tool measure showed that is dementia. These findings suggest importance early screening prevention people dysfunction, although further longitudinal research needed clarify causal relationship.

Language: Английский

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Risk of sarcopenia: A red flag for cognitive decline in postmenopause?

Maturitas, Journal Year: 2025, Volume and Issue: 194, P. 108193 - 108193

Published: Jan. 7, 2025

Language: Английский

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Sex Disparity in the Nutrition-Related Determinants of Mild Cognitive Impairment: A Case–Control Study

Nutrients, Journal Year: 2025, Volume and Issue: 17(2), P. 248 - 248

Published: Jan. 10, 2025

Sex differences in nutrition-related determinants of mild cognitive impairment (MCI) exist among the elderly. This study aimed to explore sex-specific influencing factors MCI. A case-control was conducted 2020 involving 1086 elderly people aged 55 years and above from four sites Zhejiang Province, China. Data on demographics, assessment, depression scale, daily food intake, physical examinations were collected. The assessment plant-based diet patterns depended an overall index (PDI), a healthful (hPDI), unhealthful (uPDI). Multivariate logistic regression models employed assess MCI females males. Among 571 females, 141 (24.7%) had MCI, 126 (24.5%) 514 male participants. In multivariate analysis revealed that being unmarried/divorced/widowed (OR = 1.95, 95% CI: 1.10-3.45), having 6.06, 1.87-19.66), uPDI score ≥ 2.41, 1.50-3.89) associated with significantly elevated risk Conversely, cereal consumption ≥300 g/d 0.32, 0.19-0.53) linked reduced risk. males, vegetable 150 0.39, 0.23-0.66), oil 22 0.502, 0.307-0.820), 300 0.44, 0.27-0.71) lower Meanwhile, rural residence 1.90, 1.12-3.25) advanced age, especially 75 old 4.71, 2.44-9.12), also Notably, Restricted Cubic Spline (RCS) model showed < prevalence while those faced higher indicates potential sex disparities for Future research should prospectively establish causal relationships. Additionally, precise intervention strategies are urgently needed.

Language: Английский

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The association between regional adiposity, cognitive function, and dementia-related brain changes: a systematic review

Frontiers in Medicine, Journal Year: 2023, Volume and Issue: 10

Published: June 30, 2023

Background Adiposity has been previously associated with cognitive impairment and Alzheimer’s disease related disorders (ADRD). Body mass index (BMI) is the most common measure of global adiposity, but inconsistent results were found since it a measurement. BMI does not represent regional fat distribution which differs between sexes, race, age. Regional may contribute differently to decline (AD)-related brain changes. Fat-specific targeted therapies could lead personalized improvement cognition. The goal this systematic review explore whether depots, rather than central obesity, should be used understand mechanism underlying association adiposity brain. Methods This included 33 studies in English language, conducted humans aged 18 years over assessment function, dementia, measures. We only that have assessed using imaging technics excluded articles, abstract or letters editor. Studies on children adolescents, animal studies, patients gastrointestinal diseases excluded. PubMed, PsychInfo web science as electronic databases for literature search until November 2022. Results Based currently available literature, findings suggest different depots are likely increased risk impairment, changes especially AD. However, can outcomes affect differently. Visceral adipose tissue (VAT) was studied fat, along liver through non-alcoholic fatty (NAFLD). Pancreatic least fat. Conclusion modifiable, explain discrepancies associations brain, Specific abnormal secretion factors turn penetrate blood barrier leading damage decline.

Language: Английский

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Alzheimer's disease with frailty: Prevalence, screening, assessment, intervention strategies and challenges

BioScience Trends, Journal Year: 2023, Volume and Issue: 17(4), P. 283 - 292

Published: Aug. 22, 2023

Alzheimer's disease (AD) is a neurodegenerative disorder that affects millions worldwide and expected to surge in prevalence due aging populations. Frailty, characterized by muscle function decline, becomes more prevalent with age, imposing substantial burdens on patients caregivers. This paper aimed comprehensively review the current literature AD coupled frailty, encompassing prevalence, screening, assessment, treatment while delving into field's challenges future trajectories. Frailty coexist than 30% of cases, hazard ratios above 120% indicating mutually detrimental association.Various screening tools have emerged for both frailty AD, including Fried Phenotype (FP), FRAIL scale, Edmonton Scale (EFS), Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), Clock Drawing Test (CDT), General Practitioner Cognition (GPCOG). However, none has solidified its role as definitive gold standard. The convergence electronic health records brain biomarkers heralds new era assessment. In terms intervention, non-pharmacological strategies spanning nutrition, horticulture, exercise, social interaction, along pharmacological approaches involving acetylcholinesterase inhibitors (AChEIs), N-methyl-D-aspartate (NMDA) receptor antagonists, anti-amyloid beta-protein medications, constituted cornerstones treating frailty. Technological interventions like repetitive transcranial magnetic stimulation (rTMS) also entered fold. Notably, multi-domain wield considerable potential enhancing cognition mitigating disability. long-term efficacy safety necessitate further validation. Diagnosing managing present several daunting challenges, low rates early co-diagnosis, limited clinical trial evidence, scarce integrated, pioneering service delivery models. These demand heightened attention through robust research pragmatic implementation.

Language: Английский

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Safeguarding vitality and cognition: The role of sarcopenia in intrinsic capacity decline among octogenarians from multiple cohorts

The journal of nutrition health & aging, Journal Year: 2024, Volume and Issue: 28(6), P. 100268 - 100268

Published: May 28, 2024

Sarcopenia and intrinsic capacity (IC) declines pose significant challenges to healthy aging, particularly in the rapidly growing octogenarian population. This study aimed elucidate relationship between sarcopenia IC across multiple cohorts of community-dwelling older adults.

Language: Английский

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The impact of living environmental factors on cognitive function and mild cognitive impairment: evidence from the Chinese elderly population

BMC Public Health, Journal Year: 2024, Volume and Issue: 24(1)

Published: Oct. 14, 2024

Mild cognitive impairment represents a pivotal stage in the decline of older adults, with considerable risk advancing to dementia. Recognizing how living environmental factors affect cognition is crucial for crafting effective prevention and intervention strategies. This study seeks elucidate relationship between various function, specific focus on mild impairment, within Chinese elderly population.

Language: Английский

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A nested case-control study on the effect of sarcopenia on mild cognitive impairment using the CHARLS database

Geriatric Nursing, Journal Year: 2025, Volume and Issue: 61, P. 568 - 573

Published: Jan. 1, 2025

Language: Английский

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Identification of risk factors and development of a predictive nomogram for sarcopenia in Alzheimer's disease

Alzheimer s & Dementia, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 8, 2025

Abstract INTRODUCTION Sarcopenia, with its complex diagnostic process, is a likely independent predictor of poor prognosis in patients Alzheimer's disease (AD). However, research on the clinical characteristics and biomarkers AD sarcopenia (ADSA) limited. METHODS This study included 180 ADSA 188 without (ADNSA), evaluated demographics, cognitive function, motor capacity, emotional state, daily living abilities. RESULTS were older, worse functions, more severe depression, poorer social functioning, lower abilities compared to ADNSA patients. Multivariate regression identified age, low Frailty Rating Scale (FRS) scores, serum albumin level, creatinine/cystatin C ratio (CCR) as risk factors for sarcopenia. A nomogram model based these indicators demonstrated high discriminative power utility. DISCUSSION Sarcopenia significantly affects patients’ various functions. The aids early detection personalized interventions AD. Highlights factor (AD), coexistence functions quality life Serum scores are associated both assessment (ADSA). combined indexes age at diagnosis, (CCR), FRS score, levels can aid effectively identifying personalizing population.

Language: Английский

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