Biomedicines,
Journal Year:
2024,
Volume and Issue:
12(12), P. 2665 - 2665
Published: Nov. 22, 2024
Liver
fibrosis
represents
a
common
pathway
in
the
progression
of
various
chronic
liver
diseases
towards
cirrhosis
and
failure.
Extracellular
vesicles
(EVs)
are
membrane-enclosed
particles
secreted
by
diverse
cell
types,
including
exosomes,
microvesicles,
apoptotic
vesicles,
recently
identified
migrasomes.
These
can
be
taken
up
recipient
cells,
thereby
modulating
their
function
through
transport
cargo
molecules.
EVs
facilitate
intercellular
communication
play
significant
role
development
fibrosis.
Moreover,
detection
body
fluids
offers
sensitive
diagnostic
tools
for
assessing
Additionally,
may
serve
as
therapeutic
targets,
potential
agents,
drug
delivery
vehicles.
This
article
reviews
recent
advances
field
concerning
related
diseases,
with
particular
focus
on
newly
discovered
migrasomes
intracellular
crosstalk
within
liver.
Journal of Extracellular Vesicles,
Journal Year:
2024,
Volume and Issue:
13(6)
Published: June 1, 2024
Abstract
Migrasomes
represent
a
recently
uncovered
category
of
extracellular
microvesicles,
spanning
diameter
range
500
to
3000
nm.
They
are
emitted
by
migrating
cells
and
harbour
diverse
array
RNAs
proteins.
can
be
readily
identified
in
bodily
fluids
like
serum
urine,
rendering
them
valuable
non‐invasive
source
for
disease
diagnosis
through
liquid
biopsy.
In
this
investigation,
we
introduce
streamlined
effective
approach
the
capture
quantitative
assessment
migrasomes,
employing
wheat
germ
agglutinin
(WGA)‐coated
magnetic
beads
flow
cytometry
(referred
as
WBFC).
Subsequently,
examined
levels
migrasomes
urine
kidney
(KD)
patients
with
podocyte
injury
healthy
volunteers
using
WBFC.
The
outcomes
unveiled
substantial
increase
urinary
podocyte‐derived
migrasome
concentrations
among
individuals
KD
compared
counterparts.
Notably,
were
found
express
an
abundant
quantity
phospholipase
A2
receptor
(PLA2R)
presence
PLA2R
proteins
these
holds
promise
serving
natural
antigen
quantification
autoantibodies
against
afflicted
membranous
nephropathy.
Consequently,
our
study
not
only
pioneers
novel
technique
isolation
but
also
underscores
potential
promising
biomarker
early
injury.
Biomedical Journal,
Journal Year:
2025,
Volume and Issue:
unknown, P. 100838 - 100838
Published: Feb. 1, 2025
The
increased
prevalence
of
metabolic
dysfunction-associated
steatotic
liver
disease
(MASLD)
and
its
profound
implications
for
global
health
have
sparked
extensive
research
endeavors
aimed
at
developing
potential
diagnostic
methods
this
condition.
Despite
the
achievements
in
defining
various
environmental
factors
genetic
predispositions
linked
to
MASLD,
diagnosis
clinical
staging
remain
challenging.
Recently,
extracellular
vesicles
(EVs)
garnered
considerable
attention
owing
their
roles
dysfunctions
as
biomarkers
conditions.
This
study
investigate
whether
microRNAs
(miRNAs)
serum
EVs
could
be
utilized
diagnosing
MASLD.
We
applied
an
innovative
efficient
approach
that
involves
capturing
analyzing
using
wheat
germ
agglutinin
(WGA)-coupled
magnetic
beads,
subsequently
employing
reverse
transcription
quantitative
polymerase
chain
reaction
(RT-qPCR)
analysis.
MiR-574-3p,
miR-542-3p,
miR-200a-3p
were
significantly
elevated
patients
with
indicating
markers.
has
established
a
straightforward
assay
platform
isolating
without
need
purification
quantitatively
detecting
miR-574-3p,
vesicles.
Journal of Nanobiotechnology,
Journal Year:
2025,
Volume and Issue:
23(1)
Published: March 29, 2025
Acute
kidney
injury
(AKI)
involves
the
activation
of
intrarenal
hemostatic
and
inflammatory
pathways.
Platelets
rapidly
migrate
to
affected
sites
AKI
release
extracellular
vesicles
(EVs)
laden
with
bioactive
mediators
that
regulate
inflammation
hemostasis.
While
small
interfering
RNA
(siRNA)
is
a
potent
gene-silencing
tool
for
biomedical
applications,
its
therapeutic
application
in
vivo
remains
challenging.
We
developed
an
innovative
nucleic
acid
delivery
platform
by
hybridizing
synthetic
transformation-related
protein
53
(p53)
siRNA
autologous
plasma
incubating
complex
platelets.
These
engineered
platelets
selectively
delivered
p53
injured
renal
tubular
cells
via
EV-mediated
cargo
release,
resulting
targeted
suppression
subsequent
attenuation
progression.
This
platelet-centric
translational
strategy
demonstrates
significant
potential
advancing
precision
therapies
exploiting
endogenous
platelet
trafficking
deliver
therapeutics
directly
sites.
Journal of Nanobiotechnology,
Journal Year:
2025,
Volume and Issue:
23(1)
Published: April 20, 2025
Migrasomes
are
newly
identified
organelles
that
were
first
discovered
in
2015.
Since
then,
their
biological
structure,
formation
process,
and
physiological
functions
have
been
gradually
elucidated.
Research
recent
years
has
expanded
our
understanding
of
these
aspects,
highlighting
significance
various
pathological
processes.
found
to
play
crucial
roles
normal
functions,
including
embryonic
development,
vascular
homeostasis,
material
transport,
mitochondrial
quality
control.
Additionally,
emerging
evidence
suggests
involvement
diseases;
however,
clinical
research
on
remains
limited.
Current
studies
indicate
migrasomes
may
contribute
disease
pathogenesis
hold
potential
for
diagnostic
therapeutic
applications.
This
review
consolidates
existing
migrasomes,
focusing
role
mechanisms
use
medical
By
examining
structure
function,
this
aims
generate
insights
encourage
further
research,
ultimately
contributing
advancements
prevention
treatment.
Cancer Cell International,
Journal Year:
2025,
Volume and Issue:
25(1)
Published: March 25, 2025
Migrasomes
are
a
newly
discovered
type
of
extracellular
vesicle
(EV)
formed
during
cell
migration,
playing
pivotal
role
in
intercellular
communication.
These
vesicles
generated
by
retracting
fibers
migrating
cells
and
encapsulate
various
molecules,
such
as
proteins,
lipids,
RNA,
allowing
the
transfer
biochemical
signals
to
neighboring
cells.
Current
evidence
suggests
that
migrasomes
involved
wide
range
physiological
processes
embryogenesis,
angiogenesis,
immune
modulation,
mitochondrial
quality
control.
Moreover,
implicated
pathological
conditions,
including
cancer
metastasis,
cardiovascular
diseases,
viral
infections.
To
fully
understand
their
significance,
it
is
critical
first
explore
molecular
mechanisms
underlying
formation
function.
Recent
studies
have
shed
light
on
biogenesis,
release,
biological
properties
migrasomes,
all
which
key
understanding
cell-to-cell
In
this
review,
we
provide
an
up-to-date
summary
migrasome
characterization,
activities
communication,
while
also
proposing
potential
new
functions
for
these
vesicles.
Frontiers in Cell and Developmental Biology,
Journal Year:
2024,
Volume and Issue:
12
Published: Aug. 14, 2024
Migrasomes
are
recently
identified
organelles
that
form
at
the
ends
or
forks
of
retraction
fibers
(RFs)
behind
migrating
cells
and
expelled
from
cell
through
migration.
contain
signaling
molecules
which
captured
by
surrounding
along
with
migrasomes
released
into
extracellular
environment
following
rupture
migrasomes.
Finally,
action
these
molecules,
facilitate
entire
process
information
conveyance.
In
addition,
also
serves
as
a
“scavenger”
removing
damaged
mitochondria
to
ensure
cellular
viability.
Thus,
play
pivotal
role
in
integration
temporal,
spatial,
specific
chemical
clearance
harmful
substances,
critical
for
grasping
migrasomes’
functions.
This
review
delves
latest
advancements
research,
covering
aspects
such
discovery,
distribution,
structure
characteristics,
genesis
regulation
mechanisms,
their
correlation
diseases.
Additionally,
we
scrutinize
present
investigational
findings
on
within
cancer
domain,
examining
potential
impact
prospective
research
avenues.
Frontiers in Oncology,
Journal Year:
2024,
Volume and Issue:
14
Published: July 8, 2024
Objective
Although
urinary
extracellular
vesicles
(uEVs)
have
been
extensively
studied
in
various
cancers,
their
involvement
breast
cancer
(BC)
remains
largely
unexplored.
The
non-invasive
nature
of
urine
as
a
biofluid
and
its
abundant
protein
content
offer
considerable
potential
for
the
early
detection
cancer.
Methods
This
study
analyzed
proteomic
profiles
uEVs
from
BC
patients
healthy
controls
(HC).
dysregulation
ECM1
ANXA1
was
validated
larger
cohort
128
patients,
25
HC
benign
nodules
(BBN)
by
chemiluminescence
assay
(CLIA).
expression
levels
were
also
confirmed
MMTV-PyMT
transgenic
mouse
models.
Results
LC-MS/MS
analysis
identified
571
dysregulated
proteins
patients.
selected
validation
BBN
using
CLIA,
fold
change
showed
significant
difference
more
than
10
with
p
-value<0.05.
Protein
significantly
increased
In
addition,
mice
observed
to
increase
progressively
progression
Conclusion
We
developed
simple
purification-free
platform
isolate
quantitatively
detect
WGA-coupled
magnetic
beads
CLIA.
Our
results
suggest
that
could
potentially
serve
diagnostic
biomarkers
