Nature Reviews Neurology, Journal Year: 2025, Volume and Issue: unknown
Published: April 3, 2025
Language: Английский
Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 14, 2025
Language: Английский
Citations
1
Journal of Advanced Research, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Language: Английский
Citations
0
Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown
Published: March 24, 2025
Acute brain injuries (ABI) caused by various emergencies can lead to structural and functional damage tissue. Common causes include traumatic injury, cerebral hemorrhage, ischemic stroke, heat stroke. Globally, ABI represent a significant portion of neurosurgical cases. Previous studies have emphasized the therapeutic potential stem cell-derived extracellular vesicles (EVs). Recent research indicates that EVs extracted from resident cells in central nervous system (CNS) also show following injury. Microglia, as innate immune CNS, respond changes internal environment altering their phenotype secreting impact CNS cells, including neurons, astrocytes, oligodendrocytes, endothelial neural (NSCs), microglia themselves. Notably, under different external stimuli, either promote neuronal survival, angiogenesis, myelin regeneration while reducing glial scarring inflammation, or they exert opposite effects. This review summarizes evaluates current findings on how microglia-derived influence after stimuli. It analyzes interaction mechanisms between discusses future directions clinical applications.
Language: Английский
Citations
0
Frontiers in Aging Neuroscience, Journal Year: 2025, Volume and Issue: 17
Published: March 27, 2025
Alzheimer’s disease (AD) is a widespread neurodegenerative disorder and one of the major challenges for public health. Despite extensive research, role microglia in AD remains complex dual. The aim this review to summarize most recent advances research regarding dual concerning both immunomodulation pathological progression by considering mechanisms activation microglia, effects on Aβ clearance, tau pathology, impacts due genetic variations microglial functions. Among these findings are status M1 M2 phenotypes, crucial that variants like TREM2 have modulating response microglia. This describes how modulation signaling pathway might be exploited therapeutically treatment underlines relevance personalized medicine approach.
Language: Английский
Citations
0
Advanced Materials, Journal Year: 2025, Volume and Issue: unknown
Published: March 27, 2025
Ischemic stroke represents one of the leading cerebrovascular diseases with a high rate mortality and disability globally. To date, there are no effective clinical drugs available to improve long-term outcomes for post-stroke patients. A novel nucleic acid agent circSCMH1 which can promote sensorimotor function recovery in rodent nonhuman primate animal models has been found. However, still delivery challenges overcome its implementation. Besides, effects on cognitive functions remain unexplored. Herein, lipid nanoparticle circSCMH1@LNP1 is established deliver explore therapeutic efficacy comprehensively. Distribution experiments demonstrate that intranasal administration significantly increases distribution peri-infarct region reduces non-specific accumulation other organs compared intravenous injection. Therapeutic results indicate promotes synaptic plasticity, vascular repair, neuroinflammation relief, myelin sheath formation, thereby achieving enhanced mice. In conclusion, this research presents simple LNP system efficient via repair brain injury. It envisioned study may bridge crucial gap between basic translational application, paving way implementation patient management.
Language: Английский
Citations
0
Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown
Published: April 1, 2025
Language: Английский
Citations
0
Nature Reviews Neurology, Journal Year: 2025, Volume and Issue: unknown
Published: April 3, 2025
Language: Английский
Citations
0