Prognostic Significance of Plasma Neutrophil Extracellular Trap Levels in Patients with Non-Small Cell Lung Cancer Treated with Immune Checkpoint Inhibitors DOI Creative Commons

Shun Horaguchi,

Yoshiro Nakahara,

Yuka Igarashi

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(8), P. 1831 - 1831

Published: Aug. 12, 2024

Neutrophil extracellular traps (NETs) released from neutrophils are related to cancer progression. However, the relationship between therapeutic effects of immune checkpoint inhibitors (ICIs) such as anti-PD-1 and anti-PD-L1 antibodies plasma NET concentration in patients with non-small cell lung (NSCLC) is poorly understood. In this study, concentrations citrullinated histone H3 (CitH3), a surrogate marker NETs, before/after treatment were examined advanced or recurrent NSCLC undergoing ICI (n = 185). The clinical significances levels posttreatment changes statistically evaluated. As result, multivariate Cox analysis showed that high before significant predictors unfavorable overall survival (OS;

Language: Английский

NETosis in tumour microenvironment of liver: From primary to metastatic hepatic carcinoma DOI
Yi Yang, Siyue Yu, Chao Lv

et al.

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 97, P. 102297 - 102297

Published: April 9, 2024

Language: Английский

Citations

8
Applications of gene pair methods in clinical research: advancing precision medicine DOI Creative Commons
Changchun Wu, Xuejun Xie, Xin Yang

et al.

Molecular Biomedicine, Journal Year: 2025, Volume and Issue: 6(1)

Published: April 9, 2025

Abstract The rapid evolution of high-throughput sequencing technologies has revolutionized biomedical research, producing vast amounts gene expression data that hold immense potential for biological discovery and clinical applications. Effectively mining these large-scale, high-dimensional is crucial facilitating disease detection, subtype differentiation, understanding the molecular mechanisms underlying progression. However, conventional paradigm single-gene profiling, measuring absolute levels individual genes, faces critical limitations in implementation. These include vulnerability to batch effects platform-dependent normalization requirements. In contrast, emerging approaches analyzing relative relationships between pairs demonstrate unique advantages. By focusing on binary comparisons two genes’ magnitudes, methods inherently normalize experimental variations while capturing biologically stable interaction patterns. this review, we systematically evaluate pair-based analytical frameworks. We classify eleven computational into fundamental categories: value-based quantifying differential patterns, rank-based exploiting transcriptional ordering relationships. To bridge methodological development with practical implementation, establish a reproducible pipeline incorporating feature selection, classifier construction, model evaluation modules using real-world benchmark datasets from pulmonary tuberculosis studies. findings position pair analysis as transformative omics data, direct implications precision biomarker mechanistic studies

Language: Английский

Citations

0
Identification of Molecular Subtype and Prognostic Signature for Prostate Adenocarcinoma based on Neutrophil Extracellular Traps DOI Creative Commons
Yanfen Zheng, Hui‐Chuan Sun, Shanshan Yang

et al.

Journal of Cancer, Journal Year: 2024, Volume and Issue: 15(9), P. 2678 - 2690

Published: Jan. 1, 2024

Background: Prostate adenocarcinoma (PRAD) is one of the most common cancers in male.Increasing evidences pointed out that Neutrophil Extracellular Traps (NETs) play an important role tumor angiogenesis, metastasis and drug resistance.However, limited systematic studies regarding NETs PRAD have been performed.Identification biomarkers based on might facilitate risk stratification which help optimizing clinical strategies.Methods: NETs-related genes with differential expressions were identified between adjacent normal tissues TCGA-PRAD dataset.Consensus cluster analysis was performed to determine subtypes different-expressed genes.The difference pathway enrichment, infiltrating immune cell genomic mutation also evaluated subtypes.LASSO cox regression conducted construct a prognostic signature.Result: We 19 related tissue dataset.Two significant these by consensus analysis, namely subtype 1 2. Significant differences prognosis, infiltration burden observed Cox NETs-associated signature including 13 genes, this had good performance predicting progression-free survival patients.Further integrated indicated MMP9 mostly expressed Mono/Macrophage cells regulating formation via neutrophil activation PRAD. Conclusion:To sum up, current study two molecular constructed for

Language: Английский

Citations

2
Prognostic Significance of Plasma Neutrophil Extracellular Trap Levels in Patients with Non-Small Cell Lung Cancer Treated with Immune Checkpoint Inhibitors DOI Creative Commons

Shun Horaguchi,

Yoshiro Nakahara,

Yuka Igarashi

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(8), P. 1831 - 1831

Published: Aug. 12, 2024

Neutrophil extracellular traps (NETs) released from neutrophils are related to cancer progression. However, the relationship between therapeutic effects of immune checkpoint inhibitors (ICIs) such as anti-PD-1 and anti-PD-L1 antibodies plasma NET concentration in patients with non-small cell lung (NSCLC) is poorly understood. In this study, concentrations citrullinated histone H3 (CitH3), a surrogate marker NETs, before/after treatment were examined advanced or recurrent NSCLC undergoing ICI (n = 185). The clinical significances levels posttreatment changes statistically evaluated. As result, multivariate Cox analysis showed that high before significant predictors unfavorable overall survival (OS;

Language: Английский

Citations

1