Neutrophil extracellular traps in cancer

MedComm, Journal Year: 2024, Volume and Issue: 5(8)

Published: July 15, 2024

Neutrophil extracellular traps (NETs), which consist of chromatin DNA studded with granule proteins, are released by neutrophils in response to both infectious and sterile inflammation. Beyond the canonical role defense against pathogens, extrusion NETs also contributes initiation, metastasis, therapeutic malignant diseases. Recently, have been implicated development responses various types tumors. Although extensive work regarding inflammation tumors has reported, a comprehensive summary how these web-like structures initiate propagate tumor progression under specific microenvironment is lacking. In this review, we demonstrate initiators related signaling pathways that trigger formation cancers. Additionally, review will outline current molecular mechanisms regulatory networks during dormant cancer cells awakening, circulating (CTCs) extravasation, metastatic recurrence cancer. This followed perspective on potential clinical as targets treatment local disease, including improvement efficacy existing therapies.

Language: Английский

Epigenetic DNA modifications and vitamin C in prostate cancer and benign prostatic hyperplasia: Exploring similarities, disparities, and pathogenic implications

Neoplasia, Journal Year: 2024, Volume and Issue: 58, P. 101079 - 101079

Published: Oct. 30, 2024

Language: Английский