The Role of Regulatory Cell Death in Preeclampsia

Advances in Clinical Medicine, Journal Year: 2025, Volume and Issue: 15(04), P. 1983 - 1988

Published: Jan. 1, 2025

Language: Английский

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Tertiary Lymphoid Structure in Dental Pulp: The Role in Combating Bacterial Infections

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 28, 2024

Abstract Tertiary lymphoid structure (TLS) is associated with various pathologies, including those of cancers and chronic infections. Depending on the organ, multiple factors regulate formation TLS. However, role TLS in immune response molecules that drive its remain uncertain. The dental pulp, includes a few cells surrounded by rigid mineralized tissue, opens to outside through apical foramen. Owing this special organization, pulp generates directional bacterial infection. Considering aspect, an ideal model for comprehensively studying In present study, single‐cell RNA sequencing healthy inflamed human reveals known markers TLS, C‐C motif chemokine ligand 19 (CCL19), lysosome‐associated membrane glycoprotein 3 (LAMP3), CC receptor 7 (CCR7), CD86, pulp. Compared types proportions increase, along enhanced cellular communication. Multiple immunofluorescence staining typical emerges pulpitis, consistent high expression (CCL3), which may be key driver formation. Moreover, also observed mouse pulpitis. These findings collectively offer insights into function

Language: Английский

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Exploring gene expression signatures in preeclampsia and identifying hub genes through bioinformatic analysis

Placenta, Journal Year: 2024, Volume and Issue: 159, P. 93 - 106

Published: Dec. 13, 2024

Language: Английский

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